Efficacy of piperacillin-tazobactam in the treatment of surgical wound infection after clean-contaminated head and neck oncologic surgery

Head & Neck ◽  
2004 ◽  
Vol 26 (9) ◽  
pp. 823-828 ◽  
Author(s):  
Juan P. Rodrigo ◽  
Carlos S?rez ◽  
Ricardo Bernaldez ◽  
Diego Collado ◽  
Keyword(s):  
Wound Infection ◽  
Head And Neck ◽  
Surgical Wound Infection ◽  
Surgical Wound ◽  
Oncologic Surgery ◽  
Clean Contaminated

A Predictive Model for Wound Sepsis in Oncologic Surgery of the Head and Neck

1987 ◽  
Vol 96 (2) ◽  
pp. 165-171 ◽  
Author(s):  
Randolph R. Cole ◽  
K. Thomas Robbins ◽  
James I. Cohen ◽  
Patricia F. Wolf
Keyword(s):  
At Risk ◽  
Wound Infection ◽  
Head And Neck ◽  
Predictive Model ◽  
Concomitant Disease ◽  
Postoperative Wound Infection ◽  
Oncologic Surgery ◽  
Postoperative Wound ◽  
Patients At Risk ◽  
Clean Contaminated

A prospective analysis of patients undergoing surgical resection of squamous cell carcinoma of the upper aerodigestive tract was performed in order to identify the patients at risk of postoperative wound infection and to develop a model predictive of wound infection. Fifty-nine patients who underwent extirpative clean-contaminated procedures—all of whom received cefazolin as the sole chemoprophylactic agent, were studied over a 1-year period. Twenty-three variables were recorded for each patient in the study. The overall rate of wound infection was 25.4%. Univariate analysis indicated that three variables were significantly related to the likelihood of postoperative wound infection. These included tumor stage (P = 0.0180), nodal stage (P = 0.0062), and duration of surgery (P = 0.0151). The Biomedical Computer Program (BMDP), a logistic regression program specifically designed for a binary dependent variable (infection vs. no infection) based on independent variables that may be continuous or categorical, was used in development of a model predictive of wound infection. T-stage, N-stage, and the presence of concomitant disease made up the combination of factors found to be most predictive of infection in our study population. Considering “success” to be the development of infection if the probability was 75% or higher, and the absence of infection if the probability was less than 25%, the multiple regression analysis model demonstrated a predictive success rate of 74.6%. Our results indicate that the risk of infection in patients undergoing clean-contaminated oncologic surgery of the head and neck is greatest for patients who have advanced disease that requires prolonged surgery in the presence of concomitant diseases. The correlates and predictive model generated by this study can be used as assurance that patients at risk for postoperative infection have been appropriately randomized in future prospective antibiotic trials planned at this institution.

The Role of Hair Shaving in Skull Base Surgery

2003 ◽  
Vol 128 (1) ◽  
pp. 43-47 ◽  
Author(s):  
Ziv Gil ◽  
Jacob T. Cohen ◽  
Sergei Spektor ◽  
Dan M. Fliss
Keyword(s):  
Wound Infection ◽  
Skull Base ◽  
Skull Base Surgery ◽  
Fungal Infections ◽  
Wound Infection Rate ◽  
Surgical Wound Infection ◽  
Hair Removal ◽  
Surgical Wound ◽  
Increased Risk ◽  
Clean Contaminated

OBJECTIVE: We sought to evaluate surgical wound infection rates in patients undergoing skull base surgery without hair removal. METHODS: We undertook a retrospective study of 175 skull base operations performed without hair removal. Anterior operations were conducted via the subcranial approach (n = 120) and lateral or posterior procedures via various approaches (n = 55). Wounds were examined daily during hospitalization and at routine outpatient follow-up (8 to 45 months) and classified according to the Center for Disease Control and Prevention guidelines. RESULTS: The overall surgical wound infection rate was 1.1% (2 of 175): 0.8% (1 of 120) for anterior and 1.8% (1 of 55) for lateral or posterior procedures. It was similar for clean operations (lateral and posterior) and clean-contaminated (anterior) procedures and was less than or similar to the rates reported for skull base procedures with hair removal. No wound infection occurred among the infected (trauma, fungal infections, and brain abscess) patients. CONCLUSIONS: Skull base surgery without hair removal is safe and not associated with increased risk of wound infection. The method may prevent additional psychologic stress, promote restoration of the patient's self-image, and accelerate his or her return to normal life.

scholarly journals Prophylactic activity of cephalosporins in a mouse model of surgical wound infection.

1983 ◽  
Vol 36 (2) ◽  
pp. 161-166
Author(s):  
SARAH F. GRAPPEL ◽  
LILLIAN PHILLIPS ◽  
HUGH B. LEWIS ◽  
D. GWYN MORGAN ◽  
PAUL ACTOR
Keyword(s):  
Mouse Model ◽  
Wound Infection ◽  
Surgical Wound Infection ◽  
Surgical Wound

Preincisional single-dose ceftriaxone for the prophylaxis of surgical wound infection

1995 ◽  
Vol 170 (4) ◽  
pp. 353-355 ◽  
Author(s):  
George E. Chalkiadakis ◽  
Constantin Gonnianakis ◽  
Aristidis Tsatsakis ◽  
Andreas Tsakalof ◽  
Manolis Michalodimitrakis
Keyword(s):  
Single Dose ◽  
Wound Infection ◽  
Surgical Wound Infection ◽  
Surgical Wound

Cefamandole versus cefazolin in vascular surgical wound infection prophylaxis: Cost-effectiveness and risk factors

1993 ◽  
Vol 18 (3) ◽  
pp. 470-476 ◽  
Author(s):  
William H. Edwards ◽  
Allen B. Kaiser ◽  
Scott Tapper ◽  
William H. Edwards ◽  
Raymond S. Martin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cost Effectiveness ◽  
Wound Infection ◽  
Surgical Wound Infection ◽  
Infection Prophylaxis ◽  
Surgical Wound

scholarly journals Emerging trends of nosocomial Citrobacter species surgical wound infection: concern for infection control

1970 ◽  
Vol 9 (1) ◽  
pp. 10-14
Author(s):  
B Thapa ◽  
D Karn ◽  
K Mahat
Keyword(s):  
Infection Control ◽  
Wound Infection ◽  
Infection Process ◽  
Surgical Wound Infection ◽  
Control Measures ◽  
Drug Resistant ◽  
Surgical Wound ◽  
Disk Diffusion Test ◽  
Antibiotic Susceptibility Test ◽  
Study Results

Background Surgical wound infection is a common problem among patients who undergo operation. Several factors play important role in this infection process including endemic nosocomial infection without proper infection control measures. Objectives To study the occurrence of the pathogens in post-operative wound infections, their antibiotic resistance patterns, and comparison with published reports. Methods Various specimens obtained from the surgical wound during a period of four months were processed for bacteriological culture in the Department of Microbiology, Kathmandu Medical College, Kathmandu. Antibiotic susceptibility test was performed by Kirby-Bauer disk diffusion test for pathogens isolated. The relevant literatures were searched and compared with the present study. Results Among 79 culture positive cultures, Citrobacter sp. (n=23) was most frequently isolated from surgical wound infection. Twenty strains were multidrug resistant. In comparison with other studies, this study highlights the emergence multi-drug resistant Citrobacter sp. as a leading cause of surgical wound infection. E. coli, Staphylococcus aureus, Acinetobacter sp., Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus sp., and Enterobacter sp. were also isolated from 19, 13, 10, 8, 2, 2, and 2 cultures, respectively. More than 50% of these pathogens were resistant to most of the β-lactam antibiotics tested and most of them were multi-drug resistant while these pathogens showed variable level of resistance to fluroquinolones and amino glycosides. Conclusion The frequent isolation of multi-drug resistant nosocomial strains of Citrobacter sp. in surgical wound infection is a remarkable trend. This pathogen and their resistant genes could be endemic to the institution and can cause difficult-to-treat infection if infection control committee is not revitalized and infection control strategies are not implemented. Key words Citrobacter sp.; Multi-drug resistant; surgical wound infection. DOI: http://dx.doi.org/10.3126/njdvl.v9i1.5762 NJDVL 2010; 9(1): 10-14

scholarly journals SURGICAL WOUND INFECTION IN A TERTIARY CARE TEACHING RURAL HOSPITAL

2018 ◽  
Vol 7 (51) ◽  
pp. 5470-5473
Author(s):  
Amanjee Bharti ◽  
Ram Nagina Sinha ◽  
Anuradha Sharma ◽  
Pallavi Kumari ◽  
Kumari Neha
Keyword(s):  
Wound Infection ◽  
Tertiary Care ◽  
Surgical Wound Infection ◽  
Rural Hospital ◽  
Surgical Wound ◽  
Care Teaching
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