Telomerase as an independent prognostic factor in head and neck squamous cell carcinoma

Head & Neck ◽  
2004 ◽  
Vol 26 (6) ◽  
pp. 504-512 ◽  
Author(s):  
Chun-Ta Liao ◽  
Joseph Tung-Chieh Chang ◽  
Hung-Ming Wang ◽  
I-How Chen ◽  
Chien-Yu Lin ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factor ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Independent Prognostic Factor ◽  
Neck Squamous Cell Carcinoma

scholarly journals Development and Validation of an Autophagy-Related LncRNA Prognostic Signature in Head and Neck Squamous Cell Carcinoma

2021 ◽  
Vol 11 ◽  
Author(s):  
Lin Shen ◽  
Na Li ◽  
Qin Zhou ◽  
Zhanzhan Li ◽  
Liangfang Shen
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factor ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Expression Profiles ◽  
Independent Prognostic Factor ◽  
Neck Squamous Cell Carcinoma ◽  
Risk Scores ◽  
Prognostic Signature

Head and neck squamous cell carcinoma (HNSCC) is one of the greatest public challenges because of delayed diagnosis and poor prognosis. In this study, we established an autophagy-associated long non-coding (Lnc)RNA prognostic signature to assess the prognosis of HNSCC patients. The LncRNA expression profiles and clinical information of 499 HNSCC samples were available in The Cancer Genome Atlas. Autophagic LncRNAs were analyzed using Pearson correlation. A co-expression network showed the interactions between autophagic genes and LncRNAs. An autophagic LncRNAs prognostic signature, consisting of MYOSLID, AL139287.1, AC068580.1, AL022328.2, AC104083.1, AL160006.1, AC116914.2, LINC00958, and AL450992.2, was developed through uni- and multivariate Cox regressions. High- and low-risk groups were classified based on the median risk scores. The high-risk group had significantly worse overall survival according to Kaplan–Meier curve analysis. Multivariate Cox regression demonstrated that risk scores were a significant independent prognostic factor (hazard ratio = 1.739, 95% confidence interval: 1.460–2.072), with an area under the curve of 0.735. Principal component analysis distinguished two categories based on the nine-LncRNA prognostic signature. In conclusion, this novel autophagic LncRNA signature is an independent prognostic factor and may suggest novel therapeutic targets for HNSCC.

scholarly journals Pretreatment hemoglobin level as a prognostic factor in patients with locally advanced head and neck squamous cell carcinoma

2020 ◽  
Vol 25 (5) ◽  
pp. 768-774
Author(s):  
Cecília Melo-Alvim ◽  
Patrícia Miguel-Semedo ◽  
Rita Silva Paiva ◽  
Soraia Lobo-Martins ◽  
Helena Luna-Pais ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factor ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Locally Advanced ◽  
Hemoglobin Level ◽  
Neck Squamous Cell Carcinoma ◽  
Advanced Head

Nodal Yield: Is it a Prognostic Factor for Head and Neck Squamous Cell Carcinoma?

2015 ◽  
Vol 73 (9) ◽  
pp. 1851-1859 ◽  
Author(s):  
Zhien Feng ◽  
Li Zheng Qin ◽  
Xin Huang ◽  
Jin Zhong Li ◽  
Ming Su ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factor ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Nodal Yield

Bcl-2 as Prognostic Factor in Head and Neck Squamous Cell Carcinoma

2005 ◽  
Vol 15 (5) ◽  
pp. 249-255 ◽  
Author(s):  
Lorenzo Lo Muzio ◽  
Silvia Falaschini ◽  
Antonio Farina ◽  
Corrado Rubini ◽  
Furio Pezzetti ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factor ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma
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