Quality of life and oral function in patients treated with radiation therapy for head and neck cancer

Head & Neck ◽  
2001 ◽  
Vol 23 (5) ◽  
pp. 389-398 ◽  
Author(s):  
Joel B. Epstein ◽  
Manuella Robertson ◽  
Sue Emerton ◽  
Norm Phillips ◽  
Peter Stevenson-Moore
Keyword(s):  
Quality Of Life ◽  
Radiation Therapy ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Oral Function

scholarly journals A Principal Component of Quality of Life Measures Is Associated with Survival for Head and Neck Cancer Patients Treated with Radiation Therapy

Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1155
Author(s):  
Mark Farrugia ◽  
Han Yu ◽  
Sung Jun Ma ◽  
Austin J. Iovoli ◽  
Kristopher Attwood ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Principal Component Analysis ◽  
Overall Survival ◽  
Radiation Therapy ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Principal Component ◽  
Post Treatment

Background: Health-related quality of life (HRQOL) metrics can be associated with survival in head and neck cancer (HNC); however, the impact of HRQOL recovery and the relevant HRQOL domains regarding outcome are unclear. Methods: Using a single-institution database, we retrospectively reviewed HNC patients treated with definitive or postoperative radiation therapy between 2013 and 2018. The recovery of individual HRQOL domains were determined by the ratio of the post-treatment to baseline scores. Univariate and Multivariate Cox regression were used to analyze survival outcomes. Principal component analysis was used to adjust for multicollinearity of HRQOL domains. Results: In 218 HNC patients who received radiation therapy, median follow-up was 24.8 months (interquartile range (IQR) 14.5–32.0). Principal component analysis evaluating the recovery of HRQOL domains revealed two independent principal components (PC), PC1 and PC2. PC1, which received contributions from the functional domains; physical (PF), role (RF), emotional (EF), cognitive (CF), and global health status (GQOL) was significantly associated with disease-free (HR = 0.77, 95% CI 0.61–0.98, p = 0.034) and overall survival (HR = 0.76, 95% CI 0.65–0.91, p = 0.004) on multivariate analysis and PC2, had no correlation with outcome and was mainly represented by social functioning. Unplanned hospitalization was significantly associated with lower PC1 scores (β = −0.997, Std. Error = 0.244, p < 0.001). Conclusion: Our study provides evidence that post-treatment recovery of HRQOL domains were associated with overall survival (OS) in HNC. PC1 is an attractive clinical tool to assess the recovery across multiple different HRQOL and the relationship with survival. Future prospective studies may identify patients who could benefit from additional rehabilitation based on PC1 score.

scholarly journals Assessment of xerostomia and its impact on quality of life in head and neck cancer patients undergoing radiation therapy

2017 ◽  
Vol 6 (5) ◽  
pp. 789-793 ◽  
Author(s):  
Pinelopi-Theopisti Memtsa ◽  
Maria Tolia ◽  
Ioannis Tzitzikas ◽  
John Bizakis ◽  
Kyriaki Pistevou-Gombaki ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Radiation Therapy ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer

Measurement of Quality of Life in Head and Neck Cancer Patients Utilizing the Quality of Life Radiation Therapy Questionnaire

2002 ◽  
Vol 178 (3) ◽  
pp. 153-158 ◽  
Author(s):  
Monika Janda ◽  
Darlene Johnson ◽  
Hedwig Woelfl ◽  
Michael Trimmel ◽  
Tim Bressmann ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Radiation Therapy ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer
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