Differentiated thyroid carcinoma: Comparison between papillary and follicular carcinoma in a single institute

Head & Neck ◽  
2002 ◽  
Vol 24 (7) ◽  
pp. 670-677 ◽  
Author(s):  
Sin-Ming Chow ◽  
Stephen C. K. Law ◽  
Siu-Kie Au ◽  
To-Wai Leung ◽  
Paddy T. M. Chan ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Follicular Carcinoma ◽  
Differentiated Thyroid Carcinoma

scholarly journals Pattern of metastasis in differentiated thyroid carcinoma

1970 ◽  
Vol 15 (2) ◽  
pp. 60-68
Author(s):  
Nanda Kishore Sinha ◽  
Md Monjurul Alam ◽  
Dewan Golam Md Akaiduzzaman ◽  
M Alauddin
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Thyroid Carcinoma ◽  
Papillary Carcinoma ◽  
Distant Metastasis ◽  
Follicular Carcinoma ◽  
Cervical Lymph Node Metastasis ◽  
Differentiated Thyroid Carcinoma ◽  
Age Group ◽  
Node Metastasis

Total 60 patients were selected as per described criteria from the department of Otolaryngology and head neck surgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from January 2005 to October 2006. In this study of 60 patients of differentiated thyroid carcinoma (DTC), majority of the patients are within 31-50 yrs age group with female predominance. Papillary carcinoma was more common in 31-40 yrs age group and follicular carcinoma was more common in 41-50 years. Thyroid swelling was the most common presenting symptom of DTC (91.66%), followed by cervical lymphadenopathy (33.33%). Among the 60 DTC patients, papillary carcinoma was commoner (73.33%) than follicular carcinoma (26.67%). Overall female-male ratio for these 60 patients of DTC was 1.72: 1, but in papillary type the ratio was 1.44:1. and for follicular carcinoma was 3:1. Out of 44 papillary carcinoma patients 18 patients had cervical lymph node metastasis (40.90%), and out of 16 follicular carcinoma patients 2 had cervical lymph node metastasis (12.50%); P < 0.05. Among the 44 papillary carcinoma patients only 1 had distant metastasis (2.27%), and among the 16 follicular carcinoma patients 4 had distant metastasis (25%); P <0.05. 85% of the patients were presented with unilateral and 15% were presented with bilateral lymph node metastasis. In this series, distant metastasis was found in bone and lung, Maximum lymph node metastasis was found in level II (42.10%), level III (57.89%) and level IV (42.10%). Finally the Chi-square (x2) significance test was performed according to above described findings and it was found that there is significant difference in the pattern of lymph node metastasis and of distant metastasis between papillary and follicular type of DTC (P<0.05). Key words: Thyroid carcinoma; Metastasis. DOI: 10.3329/bjo.v15i2.5059 Bangladesh J Otorhinolaryngol 2009; 15(2): 60-68

scholarly journals Differentiated Thyroid Carcinoma and Late Onset of Lung Distant Metastasis. A Case Report

Reports ◽  
2019 ◽  
Vol 2 (1) ◽  
pp. 6
Author(s):  
Alessandro Semprebene ◽  
Anna Mangano ◽  
Guido Ventroni ◽  
Raffaella Barone ◽  
Francesca Piro ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Late Onset ◽  
Follicular Carcinoma ◽  
Differentiated Thyroid Carcinoma ◽  
Cure Rate ◽  
High Cure Rate ◽  
Case Presentation ◽  
Margins Of Excision ◽  
Very High

Background: Differentiated thyroid carcinoma (DTC), which includes the papillary and follicular variants, is a common neoplasm. DTC has a very high cure rate and is treated surgically, usually followed by ablation of the post-surgical remnant with radioiodine. Case Presentation: The case of a 68-year-old male patient who underwent a minimally invasive complete thyroidectomy on July 4, 2007 for capsulated follicular carcinoma with margins of excision exempted from neoplastic infiltration (AJCC 2002 pT2 PNX PMX) is presented. Discussion: As the patient showed the presence of a pulmonary metastasis after 11 years, the potential implications of DTC follow-up management are here summarized. Conclusions: Follow up must be continued throughout life.

scholarly journals Completion Thyroidectomy for Initially Misdiagnosed Differentiated Thyroid Carcinoma-Study of 51 cases

2020 ◽  
Vol 32 (2) ◽  
pp. 22-26
Author(s):  
Subrata Ghosh ◽  
Abu Hena Mostafa Kamal ◽  
Muhammad Mahamudul Haque ◽  
Md Safiul Islam ◽  
Md Asadul Islam ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Recurrent Laryngeal Nerve ◽  
Recurrent Laryngeal Nerve Palsy ◽  
Follicular Carcinoma ◽  
Differentiated Thyroid Carcinoma ◽  
Laryngeal Nerve ◽  
Completion Thyroidectomy ◽  
Initial Surgery ◽  
Thyroid Lobectomy

Introduction: Completion thyroidectomy is the removal of any residual thyroid tissue that remains after a less than total thyroidectomy. This procedure is usually done when the final histopathlogy of the excised ipsilateral thyroid lobe reveals papillary or follicular carcinoma. Objective: A retrospective analysis was done of patients undergoing completion thyroidectomy for thyroid malignancy who had undergone surgery elsewhere for solitary thyroid nodule. The incidence of complications in these patients after re-operation was investigated in this study. Material and Method: Our study included a total 51 patients who had undergone thyroid lobectomy for a solitary nodule as initial surgery in our hospital & elsewhere and were admitted in our hospital for completion thyroidectomy when histopathology revealed malignancy in last 5 years (2014-2018). Result: In this study-51 patients were enrolled; among them 42 were female and 9 male. Their mean age was 33.6 years (range-17-59 years). After initial surgery, the histopathology revealed papillary carcinoma in 45 patients (88.24%), follicular carcinoma in 6 patients (11.76%). Four out of 51 patients had recurrent laryngeal nerve palsy after initial surgery (7.8%). None of the patients had clinical hypocalcaemia after 1st surgery. Parathyroid glands are identified and preserved in all patients during completion thyroidectomy. No patient had additional recurrent laryngeal nerve injury in 2nd surgery. Mean follow-up was one year. Transient hypoparathyroidism occurred in 9.8% patients, but no permanent hypoparathyroidism. Seven patients were lost to follow-up. Conclusion: Completion thyroidectomy is a safe and appropriate procedure for the management of initially misdiagnosed differentiated thyroid carcinoma. TAJ 2019; 32(2): 22-26

scholarly journals POSSIBILITIES OF ULTRASOUND METHOD OF RESEARCH IN EARLY DIAGNOSTICS OF THYROID CARCINOMA

2017 ◽  
Vol 176 (2) ◽  
pp. 38-44
Author(s):  
A. M. Shulutko ◽  
V. I. Semikov ◽  
A. P. Patalova ◽  
A. V. Gorbacheva ◽  
S. E. Gryaznov ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Papillary Carcinoma ◽  
Early Stage ◽  
Ultrasound Image ◽  
Follicular Carcinoma ◽  
Differentiated Thyroid Carcinoma ◽  
Accurate Analysis ◽  
Thyroid Adenomas ◽  
Symptom Complex ◽  
The Individual

OBJECTIVE. This study evaluated the possibilities of ultrasound in diagnostics of early thyroid carcinoma. MATERIALS AND METHODS. The authors have compared the ultrasound results with data of postoperative histological examination in 106 patients with differentiated thyroid carcinoma. There were 140 patients with nodular proliferating colloid goiter and 42 patients with follicular thyroid adenomas. RESULTS. The individual ultrasound signs of differentiated thyroid tumors with the size of 1cm in diameter were determined. The ultrasound symptom complex of papilliary carcinoma was defined. Ultrasound features of follicular carcinoma were nonspecific. Noncapsulation papillary carcinoma had pathognomonic ultrasound picture. The ultrasound image of follicular and papillary carcinoma would be similar in presence of capsule. CONCLUSIONS. The accurate analysis of ultrasound image gave the possibility of diagnostics of papilliary carcinoma at early stage with high degree of probability.

Clinical evaluation of a new thyroglobulin immunoradiometric assay in the follow-up of differentiated thyroid carcinoma

2003 ◽  
Vol 42 (02) ◽  
pp. 71-77 ◽  
Author(s):  
I. Schreivogel ◽  
C. Angerstein ◽  
U. Siefker ◽  
K. Lehmann ◽  
G. Altenvoerde ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Residual Disease ◽  
False Negative ◽  
Differentiated Thyroid Carcinoma ◽  
Threshold Concentration ◽  
High Rate ◽  
Functional Assay ◽  
Hypothyroid Patient ◽  
Assay Sensitivity ◽  
Significant Difference

SummaryAim: Formal and clinical comparison of a new 3rd-gene-ration-Tg-IRMA (3-G-IRMA; Dynotest®Tg-plus) with a conventional Tg-IRMA (3-G-IRMA; SELco®Tg-assay) for patients with differentiated thyroid carcinoma. In addition we evaluated, if thyroglobulin (Tg) levels above a specific threshold concentration indicate the need for further investigations for residual disease. Patients, methods: Tg concentration of 105 sera of 93 consecutive patients with a differentiated thyroid cancer was determined with both assays and compared at different cut-off values (Dynotest®Tg-plus: 0.2, 1, 2 ng/ml; SELco®Tg-assay: 0.5, 1, 2 ng/ml) with the clinical results in respect to the corresponding TSH concentration. Results: Tg concentration did not show any significant difference (SELco®Tg-assay 0.5 ng/ml, Dynotest® Tg-plus 0.2 ng/ml). The Tg-values of both assays correlated with 97%. However, correlation of recovery in both assays was small (40%). The sensitivities and specificities of both assays at different cut-offs and TSH values did not reveal significant differences. In patients with TSH concentration >30 µU/ml the functional assay sensitivity was superior to arbitrary cut-offs in the decision to start further evaluations. Conclusions: In our study neither formal nor clinical significant differences between two Tg-assays were found. In a hypothyroid patient (TSH >30 µU/ml, Tg concentration exceeding the functional assay sensitivity) further investigations for residual disease are warranted. Higher thresholds are of limited value, due to a inacceptable high rate of false negative results.

131J-speichernde pulmonale und ossäre Metastasen differenzierter Schilddrüsenkarzinome bei niedrigem Serum-Thyreoglobulinspiegel – Ausnahme in der Tumornachsorge?

1987 ◽  
Vol 26 (03) ◽  
pp. 139-142 ◽  
Author(s):  
G. Arning ◽  
O. Schober ◽  
H. Hundeshagen ◽  
Ch. Ehrenheim
Keyword(s):  
Serum Level ◽  
Thyroid Carcinoma ◽  
Bone Metastases ◽  
Differentiated Thyroid Carcinoma ◽  
Serum Thyroglobulin ◽  
Thyroglobulin Level ◽  
Low Serum

In the follow-up of differentiated thyroid carcinoma it is discussed whether the tumormarker thyroglobulin can replace the1311 scan, especially when the thyroglobulin serum level is normal. A positive1311 scan of metastases in the follow-up of patients with differentiated thyroid carcinoma combined with a low serum thyroglobulin level is extremely rare. The literature shows a frequency of about 4%. Recently we found 3 cases with a positive1311 scan demonstrating pulmonary and bone metastases whereas the serum thyroglobulin level was low.

Surgical Treatment of Differentiated Thyroid Carcinoma in Children

2000 ◽  
Vol 10 (6) ◽  
pp. 347-352 ◽  
Author(s):  
M. Bingöl-Koloğlu ◽  
F. C. Tanyel ◽  
M. E. Şenocak ◽  
N. Büyükpamukçu ◽  
A. Hiçsönmez
Keyword(s):  
Surgical Treatment ◽  
Thyroid Carcinoma ◽  
Differentiated Thyroid Carcinoma

Antiproliferative actions of 1,25(OH)2D3in differentiated thyroid carcinoma are dependent on Sirtuin1 activity

2016 ◽  
Author(s):  
Natascha Rohlen ◽  
Claudia Doring ◽  
Martin-Leo Hansmann ◽  
Klaus Badenhoop ◽  
Marissa Penna-Martinez
Keyword(s):  
Thyroid Carcinoma ◽  
Differentiated Thyroid Carcinoma
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