Can flow cytometrically determined DNA ploidy and S-phase fraction predict regional metastasis in squamous cell carcinoma of the oral cavity?

Head & Neck ◽  
2002 ◽  
Vol 24 (2) ◽  
pp. 136-142 ◽  
Author(s):  
Ryoichi Oya ◽  
Kunio Ikemura
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Dna Ploidy ◽  
S Phase ◽  
Phase Fraction ◽  
Regional Metastasis

scholarly journals ANALYSIS OF DNA PLOIDY AND S-PHASE FRACTION IN RELATION TO DEVELOPMENT OF ORAL SQUAMOUS CELL CARCINOMA: AN EXPERIMENTAL STUDY

2019 ◽  
Vol 65 (3) ◽  
pp. 2447-2455
Author(s):  
Ahmed Hussein ◽  
Sahar El-Sheikh ◽  
Mahmoud Attia ◽  
Omneya Ramadan ◽  
Enas Omar ◽  
...  
Keyword(s):  
Experimental Study ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Dna Ploidy ◽  
S Phase ◽  
Phase Fraction

scholarly journals TP53 mutations and S-phase fraction but not DNA-ploidy are independent prognostic indicators in laryngeal squamous cell carcinoma

2005 ◽  
Vol 206 (1) ◽  
pp. 181-188 ◽  
Author(s):  
Antonio Russo ◽  
Simona Corsale ◽  
Valentina Agnese ◽  
Marcella Macaluso ◽  
Sandra Cascio ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Dna Ploidy ◽  
S Phase ◽  
Phase Fraction ◽  
Prognostic Indicators ◽  
Tp53 Mutations

scholarly journals Regional metastasis to anatomies beyond traditional neck dissection boundaries: a multi-institutional analysis focused on unconventional metastases in oral cancer patients

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Weijin Gao ◽  
Zhuowei Tian ◽  
Xiaodan Fang ◽  
Jincai Xue ◽  
Zhixiang Li ◽  
...  
Keyword(s):  
Overall Survival ◽  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Metastatic Lymph Nodes ◽  
Extranodal Extension ◽  
Regional Metastasis ◽  
Metastatic Lymph

Abstract Background Regional metastasis sometimes occurs in anatomies that are not included in traditional neck dissections. The purpose of this study was to evaluate the treatment outcomes of squamous cell carcinoma of oral cavity (SCCOC) patients with unconventional metastatic lymph nodes (UMLNs) in sublingual, buccinator, and parotid anatomies. Methods This retrospective multi-institutional analysis of squamous cell carcinoma of oral cavity patients with unconventional metastatic lymph nodes was performed from January 2008 to December 2015. All the included patients received surgical treatment for unconventional metastatic lymph nodes. The end point of the study was to determine the factors influencing these patients’ survival and the corresponding solutions to improve survival. Pathological grade, contralateral metastasis, extranodal extension, and other factors were collected and analyzed by logistic regression and the Cox model. Results A total of 89 patients were identified. Among these patients, 25 (28.1%) received primary treatment, 28 (31.5%) received staged (therapeutic) neck dissections, and 36 (40.4%) had recurrent or residual diseases. Altogether, 45 patients (51%) had buccinator node metastases, 31 (35%) had sublingual metastases, 12 (14%) had parotid metastases, and 1 had both buccinator and parotid metastases. Regarding regional metastases, 31 patients (34.8%) had isolated unconventional metastatic lymph nodes. Adjuvant therapies were administered to 72 (80.9%) patients, 25 (28.1%) of whom were treated with radio-chemotherapies. The overall survival rate was 38.2%. Multivariate analysis found that the subsites of unconventional metastatic lymph nodes (P = 0.029), extranodal extension in both unconventional metastatic lymph nodes (P = 0.025) and cervical lymph nodes (P = 0.015), sites of primary or recurrent squamous cell carcinoma of oral cavity (P = 0.035), and types of neck dissections (P = 0.025) were significantly associated with overall survival. Conclusions Unconventional metastatic lymph nodes are uncommon, yet awareness of potential unconventional metastatic lymph nodes should be heightened. Early surgical interventions are warranted in patients with sublingual or buccinator metastases, while caution should be given to those with parotid metastases. Aggressive en bloc (in-continuity) resections may be mandatory in advanced oral cancer cases for close anatomic locations with possible buccal or sublingual metastases.

Overexpression of cyclin-D1, bcl-2, and bax proteins, proliferating cell nuclear antigen (PCNA), and DNA-ploidy in squamous cell carcinoma of the oral cavity

1998 ◽  
Vol 29 (11) ◽  
pp. 1189-1194 ◽  
Author(s):  
Stefania Staibano ◽  
Michele Davide Mignogna ◽  
Lorenzo Lo Muzio ◽  
Luca Di Alberti ◽  
Enrico Di Natale ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Cyclin D1 ◽  
Squamous Cell ◽  
Proliferating Cell Nuclear Antigen ◽  
Dna Ploidy ◽  
Nuclear Antigen ◽  
Proliferating Cell
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