Risk aversion and uncertainty in cost-effectiveness analysis: the expected-utility, moment-generating function approach

2005 ◽  
Vol 14 (5) ◽  
pp. 457-470 ◽  
Author(s):  
Elamin H. Elbasha
Keyword(s):  
Cost Effectiveness ◽  
Risk Aversion ◽  
Generating Function ◽  
Expected Utility ◽  
Moment Generating Function ◽  
Cost Effectiveness Analysis ◽  
Function Approach ◽  
Effectiveness Analysis

scholarly journals Handling Uncertainty in Cost-Effectiveness Analysis: Budget Impact and Risk Aversion

Healthcare ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 1419
Author(s):  
Pedram Sendi ◽  
Klazien Matter-Walstra ◽  
Matthias Schwenkglenks
Keyword(s):  
Cost Effectiveness ◽  
Risk Aversion ◽  
Joint Distribution ◽  
Budget Impact ◽  
Cost Effective ◽  
Cost Effectiveness Analysis ◽  
Policy Makers ◽  
North East ◽  
Effectiveness Analysis ◽  
The Cost

Methods to handle uncertainty in economic evaluation have gained much attention in the literature, and the cost-effectiveness acceptability curve (CEAC) is the most widely used method to summarise and present uncertainty associated with program costs and effects in cost-effectiveness analysis. Some researchers have emphasised the limitations of the CEAC for informing decision and policy makers, as the CEAC is insensitive to radial shifts of the joint distribution of incremental costs and effects in the North-East and South-West quadrants of the cost-effective plane (CEP). Furthermore, it has been pointed out that the CEAC does not incorporate risk-aversion in valuing uncertain costs and effects. In the present article, we show that the cost-effectiveness affordability curve (CEAFC) captures both dimensions of the joint distribution of incremental costs and effects on the CEP and is, therefore, sensitive to radial shifts of the joint distribution on the CEP. Furthermore, the CEAFC also informs about the budget impact of a new intervention, as it can be used to estimate the joint probability that an intervention is both affordable and cost-effective. Moreover, we show that the cost-effectiveness risk-aversion curve (CERAC) allows the analyst to incorporate different levels of risk-aversion into the analysis and can, therefore, be used to inform decision-makers who are risk-averse. We use data from a published cost-effectiveness model of palbociclib in addition to letrozole versus letrozole alone for the treatment of oestrogen-receptor positive, HER-2 negative, advanced breast cancer to demonstrate the differences between CEAC, CEAFC and CERAC, and show how these can jointly be used to inform decision and policy makers.

Cost-Effectiveness Analysis Methods

2002 ◽  
Author(s):  
Eugene Laska ◽  
Morris Meisner ◽  
Carole Siegel ◽  
Joseph Wanderling
Keyword(s):  
Cost Effectiveness ◽  
Cost Effectiveness Analysis ◽  
Effectiveness Analysis ◽  
Analysis Methods
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