scholarly journals Diastereoselective Synthesis of Novel Benzofuran Derivatives by Euparin as a Natural Compound with DMAD in the Presence of Trialkyl Phosphite

2015 ◽  
Vol 27 (2) ◽  
pp. 102-107 ◽  
Author(s):  
Parvaneh Dastoorani ◽  
Malek Taher Maghsoodlou ◽  
Mohammad A. Khalilzadeh ◽  
Santiago García-Granda ◽  
Laura Torre-Fernández ◽  
...  
Keyword(s):  
Natural Compound ◽  
Diastereoselective Synthesis ◽  
Trialkyl Phosphite

The natural compound podophyllotoxin induces growth inhibition and microtubule condensation on arabidopsis roots

2018 ◽  
Vol 45 (2) ◽  
pp. 255-262
Author(s):  
A. Costas-Gil ◽  
M.J. Reigosa ◽  
A.M. Sánchez-Moreiras
Keyword(s):  
Growth Inhibition ◽  
Natural Compound

Naturally Occurring Organic Acid-catalyzed Facile Diastereoselective Synthesis of Biologically Active (E)-3-(arylimino)indolin-2-one Derivatives in Water at Room Temperature

2019 ◽  
Vol 23 (16) ◽  
pp. 1778-1788 ◽  
Author(s):  
Gurpreet Kaur ◽  
Arvind Singh ◽  
Kiran Bala ◽  
Mamta Devi ◽  
Anjana Kumari ◽  
...  
Keyword(s):  
Room Temperature ◽  
Biologically Active ◽  
Environmentally Benign ◽  
Diastereoselective Synthesis ◽  
Substituted Anilines ◽  
Reaction Conditions ◽  
Naturally Occurring ◽  
Acid Catalyzed ◽  
Reaction Media ◽  
Column Chromatographic

A simple, straightforward and efficient method has been developed for the synthesis of (E)-3-(arylimino)indolin-2-one derivatives and (E)-2-((4-methoxyphenyl)imino)- acenaphthylen-1(2H)-one. The synthesis of these biologically-significant scaffolds was achieved from the reactions of various substituted anilines and isatins or acenaphthaquinone, respectively, using commercially available, environmentally benign and naturally occurring organic acids such as mandelic acid or itaconic acid as catalyst in aqueous medium at room temperature. Mild reaction conditions, energy efficiency, good to excellent yields, environmentally benign conditions, easy isolation of products, no need of column chromatographic separation and the reusability of reaction media are some of the significant features of the present protocol.

Diastereoselective Synthesis of Novel Optically Active Five Membered O- and N-heterocyclic Compounds

2012 ◽  
Vol 9 (2) ◽  
pp. 81-88 ◽  
Author(s):  
Ervin Kovacs ◽  
Ferenc Farkas ◽  
Angelika Thurner ◽  
Aron Szollosy ◽  
Ferenc Faigl
Keyword(s):  
Heterocyclic Compounds ◽  
Optically Active ◽  
Diastereoselective Synthesis

Antitumor Effect of Pomolic Acid in Acute Myeloid Leukemia Cells Involves Cell Death, Decreased Cell Growth and Topoisomerases Inhibition

2019 ◽  
Vol 18 (10) ◽  
pp. 1457-1468
Author(s):  
Michelle X.G. Pereira ◽  
Amanda S.O. Hammes ◽  
Flavia C. Vasconcelos ◽  
Aline R. Pozzo ◽  
Thaís H. Pereira ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Death ◽  
Acute Myeloid Leukemia ◽  
Cell Lines ◽  
Myeloid Leukemia ◽  
Natural Compound ◽  
Dna Topoisomerases ◽  
Human Dna ◽  
Pomolic Acid ◽  
Acute Myeloid

Background: Acute myeloid leukemia (AML) represents the largest number of annual deaths from hematologic malignancy. In the United States, it was estimated that 21.380 individuals would be diagnosed with AML and 49.5% of patients would die in 2017. Therefore, the search for novel compounds capable of increasing the overall survival rate to the treatment of AML cells is urgent. Objectives: To investigate the cytotoxicity effect of the natural compound pomolic acid (PA) and to explore the mechanism of action of PA in AML cell lines with different phenotypes. Methods: Three different AML cell lines, HL60, U937 and Kasumi-1 cells with different mechanisms of resistance were used to analyze the effect of PA on the cell cycle progression, on DNA intercalation and on human DNA topoisomerases (hTopo I and IIα) in vitro studies. Theoretical experiments of the inhibition of hTopo I and IIα were done to explore the binding modes of PA. Results: PA reduced cell viability, induced cell death, increased sub-G0/G1 accumulation and activated caspases pathway in all cell lines, altered the cell cycle distribution and inhibited the catalytic activity of both human DNA topoisomerases. Conclusion: Finally, this study showed that PA has powerful antitumor activity against AML cells, suggesting that this natural compound might be a potent antineoplastic agent to improve the treatment scheme of this neoplasm.

Polarographic Determination of 6-β-D-Glucopyranosyloxy-7-hydroxycoumarin

1996 ◽  
Vol 61 (3) ◽  
pp. 333-341
Author(s):  
Jiří Barek ◽  
Roman Hrnčíř ◽  
Josino C. Moreira ◽  
Jiří Zima
Keyword(s):  
Natural Compound ◽  
Mercury Electrode ◽  
Direct Determination ◽  
Differential Pulse ◽  
Differential Pulse Polarography ◽  
Whitening Agent ◽  
Polarographic Behaviour ◽  
Pulse Polarography ◽  
Dropping Mercury Electrode

The polarographic behaviour was studied for 6-β-D-glucopyranosyloxy-7-hydroxycoumarin, a natural compound serving as an optical whitening agent. The substance can be quantitated by tast polarography, differential pulse polarography using a conventional dropping mercury electrode, and differential pulse polarography using a static mercury drop electrode over the regions of 20-1 000, 2-1 000, and 0.2-1 000 μmol l-1, respectively. The methods developed for the quantitation of the compound were applied to its direct determination in a raw product.

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