Amino acid derivatives, part 3: New peptide and glycopeptide derivatives conjugated naphthalene. Synthesis, antitumor, anti-HIV, and BVDV evaluation

2005 ◽  
Vol 16 (7) ◽  
pp. 576-586 ◽  
Author(s):  
Najim A. Al-Masoudi ◽  
Iman A. Al-Masoudi ◽  
Ibrahim A. I. Ali ◽  
Bahjat Saeed ◽  
Palo La Colla
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Anti Hiv

scholarly journals Novel Nucleoside Phosphoramidates as Inhibitors of HIV: Studies on the Stereochemical Requirements of the Phosphoramidate Amino Acid

1996 ◽  
Vol 7 (4) ◽  
pp. 184-188 ◽  
Author(s):  
C. McGuigan ◽  
A. Salgado ◽  
C. Yarnold ◽  
T.Y. Harries ◽  
E. De Clercq ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Antiviral Activity ◽  
Antiviral Effect ◽  
Amino Acid Derivatives ◽  
Free Nucleotides ◽  
Nucleoside Phosphoramidates ◽  
Derivatives Of ◽  
Anti Hiv ◽  
Marked Dependence

Novel phosphoramidate derivatives of the anti-HIV nucleoside analogue d4T were designed to act as labile membrane-soluble prodrugs of the bio-active free nucleotide d4TMP. We herein reveal the very marked dependence of the antiviral activity of these phosphoramidates upon the stereochemistry of the amino acid attached to the phosphate centre; with a strong preference for the L-stereochemistry. These phosphate triesters were shown to liberate amino acid derivatives of the nucleotide intracellularly. These novel analogues, typified by alaninyl d4T monophosphate, may act as intracellular sources of the free nucleotides. The alaninyl d4T adducts themselves exert an antiviral effect when administered extracellularly, but again with clear distinctions between the L- and D-series. This evidence indicates that extracellularly administered blocked triesters derived from L-amino acids can generate d4TMP intracellularly, by a new pathway which is highly dependent on the amino acid stereochemistry.

scholarly journals Amino acid derivatives. Part 5. Synthesis and anti-HIV activity of new sebacoyl precursor derived thioureido-amino acid and phthalimide derivatives

ARKIVOC ◽  
2010 ◽  
Vol 2010 (9) ◽  
pp. 185-195 ◽  
Author(s):  
Najim A. Al-Masoudi ◽  
Nahed Al-Haidery ◽  
Naeem T. Faili ◽  
C. Pannecouque
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Anti Hiv

Amino Acid Derivatives, Part 4: Synthesis and Anti-HIV Activity of New Naphthalene Derivatives

2010 ◽  
Vol 343 (7) ◽  
pp. 397-403 ◽  
Author(s):  
Nawar S. Hamad ◽  
Nahed H. Al-Haidery ◽  
Iman A. Al-Masoudi ◽  
Mey Sabri ◽  
Luma Sabri ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Naphthalene Derivatives ◽  
Anti Hiv

LIPOPHILIC CHARACTER OF NOVEL AMINO ACID DERIVATIVES OF ZIDOVUDINE WITH ANTI HIV ACTIVITY

2002 ◽  
Vol 25 (9) ◽  
pp. 1345-1365 ◽  
Author(s):  
Guillermo N. Moroni ◽  
Mario A. Quevedo ◽  
Soledad Ravetti ◽  
Margarita C. Briñón
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Derivatives Of ◽  
Anti Hiv ◽  
Lipophilic Character

scholarly journals Amino acid derivatives. Part 6. New analogues of the angiotensin-converting enzyme 'Captopril'. Synthesis and anti-HIV activity

ARKIVOC ◽  
2010 ◽  
Vol 2010 (11) ◽  
pp. 242-253
Author(s):  
Najim A. Al-Masoudi ◽  
Nawar S. Hamad ◽  
Shahid Hameed ◽  
Christophe Pannecouque
Keyword(s):  
Amino Acid ◽  
Angiotensin Converting Enzyme ◽  
Amino Acid Derivatives ◽  
Converting Enzyme ◽  
Anti Hiv

ChemInform Abstract: Amino Acid Derivatives. Part 4. Synthesis and anti-HIV Activity of New Naphthalene Derivatives.

ChemInform ◽  
2010 ◽  
Vol 41 (47) ◽  
pp. no-no
Author(s):  
Nawar S. Hamad ◽  
Nahed H. Al-Haidery ◽  
Iman A. Al-Maosudi ◽  
Mey Sabri ◽  
Luma Sabri ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Naphthalene Derivatives ◽  
Anti Hiv

Three Amino Acid Derivatives of Valproic Acid: Design, Synthesis, Theoretical and Experimental Evaluation as Anticancer Agents

2014 ◽  
Vol 14 (7) ◽  
pp. 984-993 ◽  
Author(s):  
Gabriela Luna-Palencia ◽  
Federico Martinez-Ramos ◽  
Ismael Vasquez-Moctezuma ◽  
Manuel Fragoso-Vazquez ◽  
Jessica Mendieta-Wejebe ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Amino Acid ◽  
Anticancer Agents ◽  
Experimental Evaluation ◽  
Amino Acid Derivatives ◽  
Design Synthesis ◽  
Derivatives Of

scholarly journals In vitro anticancer potentiality and molecular modelling study of novel amino acid derivatives based on N1,N3-bis-(1-hydrazinyl-1-oxopropan-2-yl) isophthalamide

2019 ◽  
Vol 34 (1) ◽  
pp. 1247-1258 ◽  
Author(s):  
Asmaa F. Kassem ◽  
Gaber O. Moustafa ◽  
Eman S. Nossier ◽  
Hemat S. Khalaf ◽  
Marwa M. Mounier ◽  
...  
Keyword(s):  
Amino Acid ◽  
Molecular Modelling ◽  
Amino Acid Derivatives ◽  
Modelling Study
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