One-pot formation of 1,2,4-triazolo[1,5-b]pyridazine derivatives is presented in this manuscript, in which the targets are offered via cooperative Cu(i)/Zn(ii)-catalyzed tandem C–N addition and I2/KI-mediated intramolecular N–N bond formation.
A metal- and catalyst-free photoinduced radical
cascade hydroalkylation of 1,7-enynes has been
disclosed. The process is triggered by a SET event involving a photoexcited
electron-donor-aceptor complex between NHPI ester and Hantzsch ester, which
decomposes to afford a tertiary radical that is readily trapped by the enyne. <a>The method provides an operationally simple, robust and
step-economical approach to the construction of diversely functionalized
dihydroquinolinones bearing quaternary-centers. A sequential one-pot hydroalkylation-isomerization
approach is also allowed giving access
to a family of quinolinones. A wide substrate scope and high functional group tolerance was observed in both approaches</a>.
In this article we describe an efficient approach for the synthesis of cyclic diaryliodonium salts. The method is based on benzyl alcohols as starting materials and consists of an Friedel-Crafts-arylation/oxidation sequence. Besides a deep optimization, particluar focusing on the choice and ratios of the utilized Bronsted-acids and oxidants, we explore the substrate scope of this transformation. We also discuss an interesting isomerism of cyclic iodonium salts substituted with aliphatic substituents at the bridge head carbon. <br>
Bimetallic copper and zinc-catalyzed oxidative cycloaddition of 3-aminopyridazines and nitriles: a direct synthesis of 1,2,4-triazolo[1,5-b]pyridazines via C–N and N–N bond-forming process