scholarly journals Increased functional connectivity between presupplementary motor area and inferior frontal gyrus associated with the ability of motor response inhibition in obsessive–compulsive disorder

2021 ◽  
Author(s):  
Hirofumi Tomiyama ◽  
Keitaro Murayama ◽  
Kiyotaka Nemoto ◽  
Mayumi Tomita ◽  
Suguru Hasuzawa ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Obsessive Compulsive Disorder ◽  
Response Inhibition ◽  
Motor Response ◽  
Inferior Frontal Gyrus ◽  
Motor Area ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Motor Response Inhibition

Impaired response inhibition in obsessive compulsive disorder

2006 ◽  
Vol 22 (6) ◽  
pp. 404-410 ◽  
Author(s):  
R. Penadés ◽  
R. Catalán ◽  
K. Rubia ◽  
S. Andrés ◽  
M. Salamero ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Inhibitory Control ◽  
Response Inhibition ◽  
Motor Response ◽  
Selective Inhibition ◽  
Cognitive Interference ◽  
Obsessive Compulsive ◽  
Motor Responses ◽  
Compulsive Disorder ◽  
Control Functions

AbstractObjectiveThe present study investigates different three inhibitory control functions in patients with obsessive-compulsive disorder (OCD). Selective motor response inhibition was tested in a GO/NO-GO paradigm, the inhibition of a triggered motor response in a STOP paradigm and the ability to inhibit cognitive interference in a motor STROOP paradigm.Methods27 patients who met DSM-IV criteria for OCD and 25 age, handedness and IQ-matched healthy control subjects were tested in the GO/NO-GO, STOP and motor STROOP tasks.ResultsOCD patients performed significantly worse than controls in the selective inhibition of their motor responses (GO/NO-GO) and in the inhibition of cognitive interference (STROOP), and also showed worse performance in suppressing previously triggered motor responses (STOP).ConclusionPatients with OCD are impaired in motor and cognitive inhibitory mechanisms. The findings are consistent with psychobiological and neuropsychological models of OCD suggesting impairment of frontostriatal circuitries that mediate functions of inhibitory control.

Presupplementary Motor Area Hyperactivity During Response Inhibition: A Candidate Endophenotype of Obsessive-Compulsive Disorder

2012 ◽  
Vol 169 (10) ◽  
pp. 1100-1108 ◽  
Author(s):  
Stella J. de Wit ◽  
Froukje E. de Vries ◽  
Ysbrand D. van der Werf ◽  
Danielle C. Cath ◽  
Dirk J. Heslenfeld ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Response Inhibition ◽  
Motor Area ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

scholarly journals Neural correlates of working memory deficits and associations to response inhibition in obsessive compulsive disorder

2018 ◽  
Vol 17 ◽  
pp. 426-434 ◽  
Author(s):  
Stephan Heinzel ◽  
Christian Kaufmann ◽  
Rosa Grützmann ◽  
Robert Hummel ◽  
Julia Klawohn ◽  
...  
Keyword(s):  
Working Memory ◽  
Obsessive Compulsive Disorder ◽  
Response Inhibition ◽  
Memory Deficits ◽  
Neural Correlates ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

scholarly journals Disturbed Monitoring and Response Inhibition in patients with Gilles De La Tourette Syndrome and Co-Morbid Obsessive Compulsive Disorder

2003 ◽  
Vol 14 (1-2) ◽  
pp. 29-37 ◽  
Author(s):  
Sandra Verena Müller ◽  
Sönke Johannes ◽  
Berdieke Wieringa ◽  
Axel Weber ◽  
Kirsten Müller-Vahl ◽  
...  
Keyword(s):  
Executive Functions ◽  
Obsessive Compulsive Disorder ◽  
Tourette Syndrome ◽  
Response Inhibition ◽  
Error Detection ◽  
Neuropsychological Tests ◽  
Cognitive Domain ◽  
Control Group ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

Objective:Fronto-striatal dysfunction has been discussed as underlying symptoms of Tourette syndrome (TS) with co-morbid Obsessive Compulsive Disorder (OCD). This suggests possible impairments of executive functions in this disorder, which were therefore targeted in the present study.Results:A comprehensive series of neuropsychological tests examining attention, memory and executive functions was performed in a group of 14 TS/OCD in co-occurrence with OCD patients and a matched control group.Results:While attentional and memory mechanisms were not altered, TS/OCS patients showed deficits in executive functions predominately in the areas of response inhibition and action monitoring.Conclusions:These findings provide further evidence for a substantial impairment of the frontal-striatal-thalamic-frontal circuit. We propose that the deficits in monitoring, error detection and response inhibition constitute the major impairment of TS/OCD patients in the cognitive domain.

scholarly journals Trans-diagnostic comparison of response inhibition in Tourette’s disorder and obsessive-compulsive disorder

2017 ◽  
Vol 19 (7) ◽  
pp. 527-537 ◽  
Author(s):  
Siyan Fan ◽  
Danielle C. Cath ◽  
Ysbrand D. van der Werf ◽  
Stella de Wit ◽  
Dick J. Veltman ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Response Inhibition ◽  
Tourette’S Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Tourette's Disorder

Alterations in resting-state local functional connectivity in obsessive-compulsive disorder

2019 ◽  
Vol 245 ◽  
pp. 113-119 ◽  
Author(s):  
HuiHui Hao ◽  
Chuang Chen ◽  
WeiBing Mao ◽  
Wei Xia ◽  
ZhongQuan Yi ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Obsessive Compulsive Disorder ◽  
Resting State ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Local Functional

Functional connectivity in fronto-subcortical circuitry during the resting state in obsessive-compulsive disorder

2010 ◽  
Vol 474 (3) ◽  
pp. 158-162 ◽  
Author(s):  
Joon Hwan Jang ◽  
Jae-Hun Kim ◽  
Wi Hoon Jung ◽  
Jung-Seok Choi ◽  
Myung Hun Jung ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Obsessive Compulsive Disorder ◽  
Resting State ◽  
Obsessive Compulsive ◽  
Compulsive Disorder
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