scholarly journals Polygenic risk score for bipolar disorder associates with divergent thinking and brain structures in the prefrontal cortex

2021 ◽  
Author(s):  
Hikaru Takeuchi ◽  
Ryosuke Kimura ◽  
Hiroaki Tomita ◽  
Yasuyuki Taki ◽  
Yoshie Kikuchi ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Prefrontal Cortex ◽  
Risk Score ◽  
Divergent Thinking ◽  
Brain Structures ◽  
Polygenic Risk Score ◽  
Polygenic Risk

Distinct Genetic Profiles in Postpartum Depression With Different Trajectory of Illness

2020 ◽  
Author(s):  
Nagahide Takahashi ◽  
Hanae Tainaka ◽  
Tomoko Nishimura ◽  
Taeko Harada ◽  
Akemi Okumura ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Postpartum Depression ◽  
Risk Score ◽  
Association Studies ◽  
Depression Scale ◽  
Polygenic Risk Score ◽  
Genome Wide Association Studies ◽  
Gene Set Enrichment ◽  
Polygenic Risk ◽  
Gene Set

Abstract BackgroundPostpartum depression (PPD) is a common and highly heritabledisorder in the postnatal period of new mothers. The development of PPD is shown to affectneurodevelopment in children and recent evidence suggests thatthe trajectory of PPDisalso associated with children’s neurodevelopment and mental conditions. Thus, early identification and intervention for individuals at high risk of PPD are urgently needed.Additionally, it is not clear whether genetic factors affect thetrajectory of PPD. Therefore, using a polygenic risk score (PRS) approach, we investigated if PRS for depression (Depression-PRS) and bipolar disorder (Bipolar-PRS) are associated with the development and clinical course of PPD.Methods Usingrecent large genome-wide association studies(GWAS) of depression and bipolar disorder as discovery cohorts, we calculatedDepression-PRS and Bipolar-PRS in each individual. Then, we investigated the possible association between Depression-PRS and Bipolar-PRS with the development andtrajectory of PPD insubjects from the Hamamatsu Birth Cohort for mothers and children (n = 136). Depressive symptoms were assessed using the Edinburgh Postpartum Depression Scale. Gene-set enrichment analyses were used to identify pathways underlying these conditions. ResultsDepression-PRS was significantly higher in subjects with PPD than in those without PPD(t = -3.283, P = 0.002)and logistic analysis showed that Depression-PRS significantly increases therisk of developing PPD(OR [SE] = 2.274 [0.585], P = 0.002). Furthermore, Depression-PRS was positively associated with continuity of PPD (β [SE]=1.621 [0.672]; P = 0.032).Gene-set enrichment analyses revealed that pathways such as“response to hormone”(β[SE] -2.285[1.002], P < 0.001) and “epigenetic regulation”(β[SE] 2.831 [1.317], P < 0.001) were involved in the continuity of PPD. ConclusionThese preliminary findings indicate that the genetic component plays an important role not only in the development but also inthe continuity of PPD. A polygenic risk score approach could be useful to identify subjects at risk for PPD, especially for persistent PPD,who needcareful monitoring and intervention after delivery.

Correlations between immune and metabolic serum markers and schizophrenia/bipolar disorder polygenic risk score in first‐episode psychosis

2019 ◽  
Vol 14 (4) ◽  
pp. 507-511 ◽  
Author(s):  
Carlo Maj ◽  
Sarah Tosato ◽  
Roberta Zanardini ◽  
Antonio Lasalvia ◽  
Angela Favaro ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Risk Score ◽  
First Episode Psychosis ◽  
Serum Markers ◽  
First Episode ◽  
Polygenic Risk Score ◽  
Polygenic Risk ◽  
Episode Psychosis

Role of Polygenic Risk Score in the Familial Transmission of Bipolar Disorder in Youth

2021 ◽  
Author(s):  
Boris Birmaher ◽  
Danella Hafeman ◽  
John Merranko ◽  
Alyson Zwicker ◽  
Benjamin Goldstein ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Risk Score ◽  
Polygenic Risk Score ◽  
Familial Transmission ◽  
Polygenic Risk

Clock gene polygenic risk score and seasonality in major depressive disorder and bipolar disorder

2020 ◽  
Vol 19 (8) ◽  
Author(s):  
Alex Ferrer ◽  
Javier Costas ◽  
Mònica Gratacos ◽  
Èrika Martínez‐Amorós ◽  
Javier Labad ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Risk Score ◽  
Clock Gene ◽  
Polygenic Risk Score ◽  
Major Depressive ◽  
Polygenic Risk

Polygenic risk score for bipolar disorder and school grades

2020 ◽  
Vol 263 ◽  
pp. 555-557
Author(s):  
Søren D. Østergaard ◽  
John J. McGrath ◽  
Ole Mors ◽  
Preben B. Mortensen ◽  
Liselotte V. Petersen
Keyword(s):  
Bipolar Disorder ◽  
Risk Score ◽  
Polygenic Risk Score ◽  
Polygenic Risk ◽  
School Grades

scholarly journals Association of schizophrenia polygenic risk score with manic and depressive psychosis in bipolar disorder

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Matej Markota ◽  
Brandon J. Coombes ◽  
Beth R. Larrabee ◽  
Susan L. McElroy ◽  
David J. Bond ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Risk Score ◽  
Polygenic Risk Score ◽  
Polygenic Risk

P.059 The association between the polygenic risk score for bipolar disorder and school grades

2019 ◽  
Vol 29 ◽  
pp. S60-S61
Author(s):  
S.D. Ostergaard ◽  
J.J. McGrath ◽  
O. Mors ◽  
P.B. Mortensen ◽  
L.V. Petersen
Keyword(s):  
Bipolar Disorder ◽  
Risk Score ◽  
Polygenic Risk Score ◽  
Polygenic Risk ◽  
School Grades
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