scholarly journals A meta‐analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium

2021 ◽  
Author(s):  
Boris A. Gutman ◽  
Theo G.M. Erp ◽  
Kathryn Alpert ◽  
Christopher R. K. Ching ◽  
Dmitry Isaev ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Meta Analysis ◽  
Structural Shape ◽  
Deep Brain

Deep brain stimulation for multiple sclerosis tremor: A systematic review and meta-analysis

2021 ◽  
Vol 56 ◽  
pp. 103256
Author(s):  
Alireza Zali ◽  
Reza Jalili Khoshnood ◽  
Mahsa Motavaf ◽  
Alireza Salimi ◽  
Meisam Akhlaghdoust ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Systematic Review ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Meta Analysis ◽  
Deep Brain

scholarly journals A Meta-Analysis of the Effect of Subthalamic Nucleus-Deep Brain Stimulation in Parkinson's Disease-Related Pain

2021 ◽  
Vol 15 ◽  
Author(s):  
Yu Diao ◽  
Yutong Bai ◽  
Tianqi Hu ◽  
Zixiao Yin ◽  
Huangguang Liu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Deep Brain Stimulation ◽  
Subthalamic Nucleus ◽  
Brain Stimulation ◽  
Meta Analysis ◽  
Motor Symptom ◽  
Stn Dbs ◽  
Deep Brain

Pain from Parkinson's disease (PD) is a non-motor symptom affecting the quality of life and has prevalence of 20–80%. However, it is unclear whether subthalamic nucleus deep brain stimulation (STN–DBS), a well-established treatment for PD, is effective forPD-related pain. Thus, the objective of this meta-analysis was to investigate the efficacy of STN-DBS on PD-related pain and explore how its duration affects the efficacy of STN-DBS. A systematic search was performed using PubMed, Embase, and the Cochrane Library. Nine studies included numerical rating scale (NRS), visual analog scale (VAS), or non-motor symptom scale (NMSS) scores at baseline and at the last follow-up visit and therefore met the inclusion criteria of the authors. These studies exhibited moderate- to high-quality evidence. Two reviewers conducted assessments for study eligibility, risk of bias, data extraction, and quality of evidence rating. Random effect meta-analysis revealed a significant change in PD-related pain as assessed by NMSS, NRS, and VAS (P <0.01). Analysis of the short and long follow-up subgroups indicated delayed improvement in PD-related pain. These findings (a) show the efficacy of STN-DBS on PD-related pain and provide higher-level evidence, and (b) implicate delayed improvement in PD-related pain, which may help programming doctors with supplement selecting target and programming.Systematic Review Registration: This study is registered in Open Science Framework (DOI: 10.17605/OSF.IO/DNM6K).

Subthalamic nucleus deep brain stimulation: Summary and meta-analysis of outcomes

2006 ◽  
Vol 21 (S14) ◽  
pp. S290-S304 ◽  
Author(s):  
Galit Kleiner-Fisman ◽  
Jan Herzog ◽  
David N. Fisman ◽  
Filippo Tamma ◽  
Kelly E. Lyons ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Subthalamic Nucleus ◽  
Brain Stimulation ◽  
Meta Analysis ◽  
Deep Brain

scholarly journals Deep Brain Stimulation for Multiple Sclerosis Tremor: A Meta‐Analysis

2019 ◽  
Vol 23 (4) ◽  
pp. 463-468 ◽  
Author(s):  
Nicholas J. Brandmeir ◽  
Ann Murray ◽  
Cletus Cheyuo ◽  
Christopher Ferari ◽  
Ali R. Rezai
Keyword(s):  
Multiple Sclerosis ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Meta Analysis ◽  
Deep Brain

scholarly journals Deep Brain Stimulation Is Effective for Treatment-Resistant Depression: A Meta-Analysis and Meta-Regression

2020 ◽  
Vol 9 (9) ◽  
pp. 2796
Author(s):  
Frederick L. Hitti ◽  
Andrew I. Yang ◽  
Mario A. Cristancho ◽  
Gordon H. Baltuch
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Meta Analysis ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Significant Difference ◽  
Resistant Depression ◽  
Meta Regression ◽  
K 12 ◽  
Deep Brain

Major depressive disorder (MDD) is a leading cause of disability and a significant cause of mortality worldwide. Approximately 30–40% of patients fail to achieve clinical remission with available pharmacological treatments, a clinical course termed treatment-resistant depression (TRD). Numerous studies have investigated deep brain stimulation (DBS) as a therapy for TRD. We performed a meta-analysis to determine efficacy and a meta-regression to compare stimulation targets. We identified and screened 1397 studies. We included 125 citations in the qualitative review and considered 26 for quantitative analysis. Only blinded studies that compared active DBS to sham stimulation (k = 12) were included in the meta-analysis. The random-effects model supported the efficacy of DBS for TRD (standardized mean difference = −0.75, <0 favors active stimulation; p = 0.0001). The meta-regression did not demonstrate a statistically significant difference between stimulation targets (p = 0.45). While enthusiasm for DBS treatment of TRD has been tempered by recent randomized trials, this meta-analysis reveals a significant effect of DBS for the treatment of TRD. Additionally, the majority of trials have demonstrated the safety and efficacy of DBS for this indication. Further trials are required to determine the optimal stimulation parameters and patient populations for which DBS would be effective. Particular attention to factors including electrode placement technique, patient selection, and long-term follow-up is essential for future trial design.

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