scholarly journals Connectivity gradients on tractography data: Pipeline and example applications

2021 ◽  
Author(s):  
Guilherme Blazquez Freches ◽  
Koen V. Haak ◽  
Christian F. Beckmann ◽  
Rogier B. Mars
Keyword(s):  
Data Pipeline ◽  
Tractography Data

scholarly journals Retrospective analysis of hemispheric structural network change as a function of location and size of glioma

2020 ◽  
Author(s):  
Shawn D’Souza ◽  
Lisa Hirt ◽  
David R Ormond ◽  
John A Thompson
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Temporal Lobe ◽  
Diffusion Tensor ◽  
Brain Regions ◽  
Structural Network ◽  
Tumour Location ◽  
The Impact ◽  
Tractography Data ◽  
Diffusion Tensor Imaging Tractography

Abstract Gliomas are neoplasms that arise from glial cell origin and represent the largest fraction of primary malignant brain tumours (77%). These highly infiltrative malignant cell clusters modify brain structure and function through expansion, invasion and intratumoral modification. Depending on the growth rate of the tumour, location and degree of expansion, functional reorganization may not lead to overt changes in behaviour despite significant cerebral adaptation. Studies in simulated lesion models and in patients with stroke reveal both local and distal functional disturbances, using measures of anatomical brain networks. Investigations over the last two decades have sought to use diffusion tensor imaging tractography data in the context of intracranial tumours to improve surgical planning, intraoperative functional localization, and post-operative interpretation of functional change. In this study, we used diffusion tensor imaging tractography to assess the impact of tumour location on the white matter structural network. To better understand how various lobe localized gliomas impact the topology underlying efficiency of information transfer between brain regions, we identified the major alterations in brain network connectivity patterns between the ipsilesional versus contralesional hemispheres in patients with gliomas localized to the frontal, parietal or temporal lobe. Results were indicative of altered network efficiency and the role of specific brain regions unique to different lobe localized gliomas. This work draws attention to connections and brain regions which have shared structural susceptibility in frontal, parietal and temporal lobe glioma cases. This study also provides a preliminary anatomical basis for understanding which affected white matter pathways may contribute to preoperative patient symptomology.

scholarly journals Structural brain network topology underpinning ADHD and response to methylphenidate treatment

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kristi R. Griffiths ◽  
Taylor A. Braund ◽  
Michael R. Kohn ◽  
Simon Clarke ◽  
Leanne M. Williams ◽  
...  
Keyword(s):  
Brain Network ◽  
Global Network ◽  
Support Vector ◽  
Structural Topology ◽  
Local Efficiency ◽  
Structural Brain Network ◽  
Structural Architecture ◽  
The Right ◽  
Tractography Data ◽  
Treatment Prognosis

AbstractBehavioural disturbances in attention deficit hyperactivity disorder (ADHD) are thought to be due to dysfunction of spatially distributed, interconnected neural systems. While there is a fast-growing literature on functional dysconnectivity in ADHD, far less is known about the structural architecture underpinning these disturbances and how it may contribute to ADHD symptomology and treatment prognosis. We applied graph theoretical analyses on diffusion MRI tractography data to produce quantitative measures of global network organisation and local efficiency of network nodes. Support vector machines (SVMs) were used for comparison of multivariate graph measures of 37 children and adolescents with ADHD relative to 26 age and gender matched typically developing children (TDC). We also explored associations between graph measures and functionally-relevant outcomes such as symptom severity and prediction of methylphenidate (MPH) treatment response. We found that multivariate patterns of reduced local efficiency, predominantly in subcortical regions (SC), were able to distinguish between ADHD and TDC groups with 76% accuracy. For treatment prognosis, higher global efficiency, higher local efficiency of the right supramarginal gyrus and multivariate patterns of increased local efficiency across multiple networks at baseline also predicted greater symptom reduction after 6 weeks of MPH treatment. Our findings demonstrate that graph measures of structural topology provide valuable diagnostic and prognostic markers of ADHD, which may aid in mechanistic understanding of this complex disorder.

scholarly journals A UNIFIED COMMUNITY DETECTION, VISUALIZATION AND ANALYSIS METHOD

2014 ◽  
Vol 17 (01) ◽  
pp. 1450001 ◽  
Author(s):  
MICHEL CRAMPES ◽  
MICHEL PLANTIÉ
Keyword(s):  
Community Detection ◽  
Directed Graphs ◽  
Real Data ◽  
Semantic Interpretation ◽  
Detection Methods ◽  
Analysis Method ◽  
Overlapping Communities ◽  
Social Graphs ◽  
Tractography Data ◽  
Research Domain

With the widespread social networks on the Internet, community detection in social graphs has recently become an important research domain. Interest was initially limited to unipartite graph inputs and partitioned community outputs. More recently, bipartite graphs, directed graphs and overlapping communities have all been investigated. Few contributions however have encompassed all three types of graphs simultaneously. In this paper, we present a method that unifies community detection for these three types of graphs while at the same time it merges partitioned and overlapping communities. Moreover, the results are visualized in a way that allows for analysis and semantic interpretation. For validation purposes this method is experimented on some well-known simple benchmarks and then applied to real data: photos and tags in Facebook and Human Brain Tractography data. This last application leads to the possibility of applying community detection methods to other fields such as data analysis with original enhanced performances.

Towards Automated Detection of Data Pipeline Faults

2020 ◽  
Author(s):  
Aiswarya Raj M ◽  
Jan Bosch ◽  
Helena Holmstrom Olsson ◽  
Tian J. Wang
Keyword(s):  
Automated Detection ◽  
Data Pipeline

HDF5-Based I/O Optimization for Extragalactic HI Data Pipeline of FAST

2020 ◽  
pp. 656-672
Author(s):  
Yiming Ji ◽  
Ce Yu ◽  
Jian Xiao ◽  
Shanjiang Tang ◽  
Hao Wang ◽  
...  
Keyword(s):  
Data Pipeline
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