scholarly journals Lifelong bilingualism and mechanisms of neuroprotection in Alzheimer dementia

2021 ◽  
Author(s):  
Arianna Sala ◽  
Maura Malpetti ◽  
Mohsen Farsad ◽  
Francesca Lubian ◽  
Giuseppe Magnani ◽  
...  
Keyword(s):  
Alzheimer Dementia

Antioxidant Status and Energy State of Erythrocytes in Alzheimer Dementia: Probing for Markers

2012 ◽  
Vol 11 (7) ◽  
pp. 926-932 ◽  
Author(s):  
Elena A. Kosenko ◽  
Gjumrakch Aliev ◽  
Lyudmila A. Tikhonova ◽  
Yi Li ◽  
Armenuhi C. Poghosyan ◽  
...  
Keyword(s):  
Antioxidant Status ◽  
Energy State ◽  
Alzheimer Dementia

P3-017: Rare variants in PLD3 do not increase risk in a belgian cohort of early-onset Alzheimer dementia patients

2015 ◽  
Vol 11 (7S_Part_13) ◽  
pp. P626-P626
Author(s):  
Rita Cacace ◽  
Tobi Van den Bossche ◽  
Sebastiaan Engelborghs ◽  
Mathieu Vandenbulcke ◽  
Rik Vandenberghe ◽  
...  
Keyword(s):  
Early Onset ◽  
Rare Variants ◽  
Alzheimer Dementia ◽  
Dementia Patients ◽  
Increase Risk

scholarly journals Shape Profile of Corpus Callosum As a Signature to Phenotype Different Dementia

2020 ◽  
Author(s):  
Sandhya Mangalore ◽  
Shiva Shanker Reddy Mukku ◽  
Sriharish Vankayalapati ◽  
Palanimuthu Thangaraju Sivakumar ◽  
Mathew Varghese
Keyword(s):  
Corpus Callosum ◽  
Frontotemporal Dementia ◽  
Corticobasal Degeneration ◽  
Lewy Body Dementia ◽  
Clinical History ◽  
The Body ◽  
Cortical Atrophy ◽  
Alzheimer Dementia ◽  
Geriatric Clinic ◽  
Cortical Regions

Abstract Background Phenotyping dementia is always a complex task for a clinician. There is a need for more practical biomarkers to aid clinicians. Objective The aim of the study is to investigate the shape profile of corpus callosum (CC) in different phenotypes of dementia. Materials and Methods Our study included patients who underwent neuroimaging in our facility as a part of clinical evaluation for dementia referred from Geriatric Clinic (2017–2018). We have analyzed the shape of CC and interpreted the finding using a seven-segment division. Results The sample included MPRAGE images of Alzheimer’ dementia (AD) (n = 24), posterior cortical atrophy- Alzheimer’ dementia (PCA-AD) (n = 7), behavioral variant of frontotemporal dementia (Bv-FTD) (n = 17), semantic variant frontotemporal dementia (Sv-FTD) (n = 11), progressive nonfluent aphasia (PNFA) (n = 4), Parkinson’s disease dementia (PDD) (n = 5), diffuse Lewy body dementia (n = 7), progressive supranuclear palsy (PSP) (n = 3), and corticobasal degeneration (CBD) (n = 3). We found in posterior dementias such as AD and PCA-AD that there was predominant atrophy of splenium of CC. In Bv-FTD, the genu and anterior half of the body of CC was atrophied, whereas in PNFA, PSP, PDD, and CBD there was atrophy of the body of CC giving a dumbbell like profile. Conclusion Our study findings were in agreement with the anatomical cortical regions involved in different phenotypes of dementia. Our preliminary study highlighted potential usefulness of CC in the clinical setting for phenotyping dementia in addition to clinical history and robust biomarkers.

scholarly journals Dementia and Major Neurocognitive Disorders: Some Lessons Learned One Century after the first Alois Alzheimer’s Clinical Notes

Geriatrics ◽  
2021 ◽  
Vol 6 (1) ◽  
pp. 5
Author(s):  
Donatella Rita Petretto ◽  
Gian Pietro Carrogu ◽  
Luca Gaviano ◽  
Lorenzo Pili ◽  
Roberto Pili
Keyword(s):  
Young Woman ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Neurocognitive Disorders ◽  
Lessons Learned ◽  
Alzheimer Dementia ◽  
Clinical Notes ◽  
Alois Alzheimer ◽  
Clinical Signs And Symptoms

Over 100 years ago, Alois Alzheimer presented the clinical signs and symptoms of what has been later called “Alzheimer Dementia” in a young woman whose name was Augustine Deter [...]

Somatostatin replacement therapy for alzheimer dementia

1991 ◽  
Vol 30 (4) ◽  
pp. 610-613 ◽  
Author(s):  
M. Maral Mouradian ◽  
Jerome Blin ◽  
Marianne Giuffra ◽  
Isabella J. E. Heuser ◽  
Fabio Baronti ◽  
...  
Keyword(s):  
Replacement Therapy ◽  
Alzheimer Dementia

Modeling the time-course of Alzheimer dementia

2001 ◽  
Vol 3 (1) ◽  
pp. 20-28 ◽  
Author(s):  
J. Wesson Ashford ◽  
Frederick A. Schmitt
Keyword(s):  
Time Course ◽  
Alzheimer Dementia

Abstract 1122‐000036: Demographic and Pharmacological Characteristics of Alzheimer Dementia Patients with Mild Cognitive Impairment stratified by Gender

2021 ◽  
Vol 1 (S1) ◽  
Author(s):  
Oreoluwa O Coker‐Ayo ◽  
Samuel Nathaniel ◽  
Chika Onuoha ◽  
Nneoma Madubuike ◽  
Lidadi Agbomi ◽  
...  
Keyword(s):  
Gender Differences ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Regression Models ◽  
Operating Characteristic ◽  
Management Strategies ◽  
Roc Curve Analysis ◽  
Alzheimer Dementia ◽  
Dementia Patients ◽  
Specific Factors

Introduction : The role that specific clinical factors play in contributing to gender differences in Alzheimer’s patients with mild cognitive impairment (MCI) is not yet fully understood. In this study, we tested the hypothesis that pharmacological, demographic, and risk factors may contribute to gender difference in Alzheimer’s patients with MCI. Methods : Methods Data collected for 5 years was analyzed using a retrospective data analytical approach on 33,064 Alzheimer patients, including 13,569 men and 19,495 women that presented with MCI. Receiver operating characteristic (ROC) curve analysis and multivariate regression models were used to identify specific factors that contribute to gender differences in MCI patients. Results : Results Our records indicate that women that presented with MCI were more likely to be taking Buspirone (OR = 0.767, 95% CI, 0.683‐0.861, P<0.001) while men within this population were more likely to be taking Galantamine (OR = 0.559, 95% CI, 0.382‐0.818, P<0.001). ETOH use was associated with MCI in both men (OR = 0.696, 95% CI, 0.638‐0.760, P<0.001) and women with Alzheimer’s Dementia (OR = 0.484, 95% CI, 0.442‐0.529, P<0.001). Conclusions : Conclusion Our findings reveal gender differences in men and women that presented with MCI. Management strategies should consider identified factors to provide better care for Alzheimer patients with MCI.

scholarly journals Principal Components Analysis of Brain Metabolism Predicts Development of Alzheimer Dementia

2018 ◽  
Vol 60 (6) ◽  
pp. 837-843 ◽  
Author(s):  
Ganna Blazhenets ◽  
Yilong Ma ◽  
Arnd Sörensen ◽  
Gerta Rücker ◽  
Florian Schiller ◽  
...  
Keyword(s):  
Principal Components Analysis ◽  
Principal Components ◽  
Brain Metabolism ◽  
Alzheimer Dementia ◽  
Components Analysis

CENTRAL CHOLINERGIC ACTIVITY IN ALZHEIMER DEMENTIA

1980 ◽  
Vol 39 (3) ◽  
pp. 351 ◽  
Author(s):  
J. D. Dziedzic ◽  
K. Iqbal ◽  
H. M. Wisniewski
Keyword(s):  
Cholinergic Activity ◽  
Alzheimer Dementia
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