scholarly journals Anticipating control over aversive stimuli is mediated by the medial prefrontal cortex: An fMRI study with healthy adults

2021 ◽  
Author(s):  
Laura Maria Wade‐Bohleber ◽  
Amelie Haugg ◽  
Sabrina Huber ◽  
Jutta Ernst ◽  
Simone Grimm ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Healthy Adults ◽  
Aversive Stimuli ◽  
Fmri Study

Activation of the medial prefrontal cortex and extended amygdala by individual ratings of emotional arousal: a fMRI study

2003 ◽  
Vol 53 (3) ◽  
pp. 211-215 ◽  
Author(s):  
K.Luan Phan ◽  
Stephan F Taylor ◽  
Robert C Welsh ◽  
Laura R Decker ◽  
Douglas C Noll ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Emotional Arousal ◽  
Extended Amygdala ◽  
Fmri Study

Pain-related autonomic response is modulated by the medial prefrontal cortex: An ECG–fMRI study in men

2015 ◽  
Vol 349 (1-2) ◽  
pp. 202-208 ◽  
Author(s):  
Gabor Perlaki ◽  
Gergely Orsi ◽  
Attila Schwarcz ◽  
Peter Bodi ◽  
Eniko Plozer ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Autonomic Response ◽  
Fmri Study

scholarly journals Basolateral amygdala input to the medial prefrontal cortex controls obsessive-compulsive disorder-like checking behavior

2019 ◽  
Vol 116 (9) ◽  
pp. 3799-3804 ◽  
Author(s):  
Tingting Sun ◽  
Zihua Song ◽  
Yanghua Tian ◽  
Wenbo Tian ◽  
Chunyan Zhu ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Obsessive Compulsive Disorder ◽  
Medial Prefrontal Cortex ◽  
Basolateral Amygdala ◽  
Obsessive Compulsive ◽  
Neuronal Tracing ◽  
Compulsive Disorder ◽  
Glutamatergic Neurons ◽  
Fmri Study ◽  
Checking Behavior

Obsessive-compulsive disorder (OCD) affects ∼1 to 3% of the world’s population. However, the neural mechanisms underlying the excessive checking symptoms in OCD are not fully understood. Using viral neuronal tracing in mice, we found that glutamatergic neurons from the basolateral amygdala (BLAGlu) project onto both medial prefrontal cortex glutamate (mPFCGlu) and GABA (mPFCGABA) neurons that locally innervate mPFCGlu neurons. Next, we developed an OCD checking mouse model with quinpirole-induced repetitive checking behaviors. This model demonstrated decreased glutamatergic mPFC microcircuit activity regulated by enhanced BLAGlu inputs. Optical or chemogenetic manipulations of this maladaptive circuitry restored the behavioral response. These findings were verified in a mouse functional magnetic resonance imaging (fMRI) study, in which the BLA–mPFC functional connectivity was increased in OCD mice. Together, these findings define a unique BLAGlu→mPFCGABA→Glu circuit that controls the checking symptoms of OCD.

scholarly journals History of Suicide Attempt Is Associated with Reduced Medial Prefrontal Cortex Activity during Emotional Decision-Making among Men with Schizophrenia: An Exploratory fMRI Study

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Stéphane Potvin ◽  
Andràs Tikàsz ◽  
Stéphane Richard-Devantoy ◽  
Ovidiu Lungu ◽  
Alexandre Dumais
Keyword(s):  
Decision Making ◽  
Prefrontal Cortex ◽  
Suicide Attempt ◽  
Medial Prefrontal Cortex ◽  
Suicidal Attempt ◽  
Risky Decision ◽  
Fmri Study ◽  
History Of ◽  
Brain Reward ◽  
Suicidal Ideas

Despite the high prevalence of suicidal ideas/attempts in schizophrenia, only a handful of neuroimaging studies have examined the neurobiological differences associated with suicide risk in this population. The main objective of the current exploratory study is to examine the neurofunctional correlates associated with a history of suicide attempt in schizophrenia, using a risky decision-making task, in order to show alterations in brain reward regions in this population. Thirty-two male outpatients with schizophrenia were recruited: 13 patients with (SCZ + S) and 19 without a history of suicidal attempt (SCZ − S). Twenty-one healthy men with no history of mental disorders or suicidal attempt/idea were also recruited. Participants were scanned using fMRI while performing the Balloon Analogue Risk Task. A rapid event-related fMRI paradigm was used, separating decision and outcome events, and the explosion probabilities were included as parametric modulators. The most important finding of this study is that SCZ + S patients had reduced activations of the medial prefrontal cortex during the success outcome event (with parametric modulation), relative to both SCZ − S patients and controls, as illustrated by a spatial conjunction analysis. These exploratory results suggest that a history of suicidal attempt in schizophrenia is associated with blunted brain reward activity during emotional decision-making.

Specific role of medial prefrontal cortex in retrieving recent autobiographical memories: An fMRI study of young female subjects

Cortex ◽  
2010 ◽  
Vol 46 (1) ◽  
pp. 29-39 ◽  
Author(s):  
Silvia Oddo ◽  
Silke Lux ◽  
Peter H. Weiss ◽  
Anna Schwab ◽  
Harald Welzer ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Young Female ◽  
Specific Role ◽  
Autobiographical Memories ◽  
Fmri Study ◽  
Female Subjects

scholarly journals Aversive stimuli bias corticothalamic responses to motivationally significant cues

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Federica Lucantonio ◽  
Eunyoung Kim ◽  
Zhixiao Su ◽  
Anna J Chang ◽  
Bilal A Bari ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Information Flow ◽  
Paraventricular Nucleus ◽  
Prior Experience ◽  
Behavioral Responses ◽  
Negative Bias ◽  
Behavioral Bias ◽  
Aversive Stimuli ◽  
History Of

Making predictions about future rewards or punishments is fundamental to adaptive behavior. These processes are influenced by prior experience. For example, prior exposure to aversive stimuli or stressors changes behavioral responses to negative- and positive-value predictive cues. Here, we demonstrate a role for medial prefrontal cortex (mPFC) neurons projecting to the paraventricular nucleus of the thalamus (PVT; mPFC→PVT) in this process. We found that a history of aversive stimuli negatively biased behavioral responses to motivationally relevant cues in mice and that this negative bias was associated with hyperactivity in mPFC→PVT neurons during exposure to those cues. Furthermore, artificially mimicking this hyperactive response with selective optogenetic excitation of the same pathway recapitulated the negative behavioral bias induced by aversive stimuli, whereas optogenetic inactivation of mPFC→PVT neurons prevented the development of the negative bias. Together, our results highlight how information flow within the mPFC→PVT circuit is critical for making predictions about motivationally-relevant outcomes as a function of prior experience.

scholarly journals Punishment history biases corticothalamic responses to motivationally-significant stimuli

2020 ◽  
Author(s):  
Federica Lucantonio ◽  
Zhixiao Su ◽  
Anna J. Chang ◽  
Bilal A. Bari ◽  
Jeremiah Y. Cohen
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Information Flow ◽  
Paraventricular Nucleus ◽  
Prior Experience ◽  
Behavioral Responses ◽  
Negative Bias ◽  
Behavioral Bias ◽  
Aversive Stimuli ◽  
History Of

Making predictions about future rewards or punishments is fundamental to adaptive behavior. These processes are influenced by prior experience. For example, prior exposure to aversive stimuli or stressors changes behavioral responses to negative- and positive-value predictive cues. Here, we demonstrate a role for medial prefrontal cortex (mPFC) neurons projecting to the paraventricular nucleus of the thalamus (PVT; mPFC→PVT) in this process. We found that a history of punishments negatively biased behavioral responses to motivationally-relevant stimuli in mice and that this negative bias was associated with hyperactivity in mPFC→PVT neurons during exposure to those cues. Furthermore, artificially mimicking this hyperactive response with selective optogenetic excitation of the same pathway recapitulated the punishmentinduced negative behavioral bias. Together, our results highlight how information flow within the mPFC→PVT circuit is critical for making predictions about imminent motivationally-relevant outcomes as a function of prior experience.

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