scholarly journals Comparison of structural MRI brain measures between 1. 5 and 3 T : Data from the Lothian Birth Cohort 1936

2021 ◽  
Author(s):  
Colin R. Buchanan ◽  
Susana Muñoz Maniega ◽  
Maria C. Valdés Hernández ◽  
Lucia Ballerini ◽  
Gayle Barclay ◽  
...  
Keyword(s):  
Birth Cohort ◽  
Structural Mri ◽  
Mri Brain ◽  
Lothian Birth Cohort

scholarly journals Alzheimer’s Disease Susceptibility Genes APOE and TOMM40, and Hippocampal Volumes in the Lothian Birth Cohort 1936

PLoS ONE ◽  
2013 ◽  
Vol 8 (11) ◽  
pp. e80513 ◽  
Author(s):  
Donald M. Lyall ◽  
Natalie A. Royle ◽  
Sarah E. Harris ◽  
Mark E. Bastin ◽  
Susana Muñoz Maniega ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Birth Cohort ◽  
Disease Susceptibility ◽  
Susceptibility Genes ◽  
Lothian Birth Cohort

scholarly journals Longitudinal Associations Between Loneliness and Cognitive Ability in the Lothian Birth Cohort 1936

2018 ◽  
Vol 74 (8) ◽  
pp. 1376-1386 ◽  
Author(s):  
Judith A Okely ◽  
Ian J Deary
Keyword(s):  
Cognitive Ability ◽  
Birth Cohort ◽  
Processing Speed ◽  
Verbal Memory ◽  
Cognitive Abilities ◽  
Birth Cohort Study ◽  
Visuospatial Ability ◽  
Lothian Birth Cohort ◽  
Longitudinal Associations ◽  
Reciprocal Associations

Abstract Objectives Loneliness is associated with poorer cognitive function in old age; however, the direction of this association is unknown. We tested for reciprocal associations between loneliness and the cognitive ability domains of processing speed, visuospatial ability, verbal memory, and crystallized ability. Method We used three triennial waves of longitudinal data from the Lothian Birth Cohort Study 1936, and tested for cross-lagged associations between loneliness and cognitive abilities using cross-lagged panel models. Results Better processing speed, visuospatial ability, or crystallized ability at age 73, was associated with less positive changes in loneliness between ages 73 and 76; however, these associations were not replicated between ages 76 and 79. Loneliness at ages 73 and 76 did not predict subsequent changes in cognitive abilities. Discussion Our findings indicate an association between cognitive ability and loneliness, such that individuals with lower cognitive abilities at age 73 may be at a slightly higher risk of becoming lonely. However, we did not find support for the hypothesis that loneliness causes a decline in cognitive health.

scholarly journals Early life characteristics and late life burden of cerebral small vessel disease in the Lothian Birth Cohort 1936

Aging ◽  
2016 ◽  
Vol 8 (9) ◽  
pp. 2039-2061 ◽  
Author(s):  
Thalia S. Field ◽  
Fergus N. Doubal ◽  
Wendy Johnson ◽  
Ellen Backhouse ◽  
Caroline McHutchison ◽  
...  
Keyword(s):  
Birth Cohort ◽  
Early Life ◽  
Small Vessel Disease ◽  
Late Life ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Vessel Disease ◽  
Lothian Birth Cohort

scholarly journals Comparison of structural MRI brain measures between 1.5T and 3T: data from the Lothian Birth Cohort 1936

2021 ◽  
Author(s):  
Colin R Buchanan ◽  
Susana Munoz Maniega ◽  
Maria del Carmen Valdes Hernandez ◽  
Lucia Ballerini ◽  
Gayle Barclay ◽  
...  
Keyword(s):  
Cross Validation ◽  
Intraclass Correlation ◽  
Structural Mri ◽  
Community Dwelling ◽  
Lothian Birth Cohort ◽  
Cortical Regions ◽  
Absolute Measurements ◽  
Structural Networks ◽  
And Diffusion ◽  
Fold Cross Validation

Multi-scanner MRI studies are reliant on understanding the apparent differences in imaging measures between different scanners. We provide a comprehensive analysis of T1-weighted and diffusion MRI (dMRI) structural brain measures between a 1.5T GE Signa Horizon HDx and a 3T Siemens Magnetom Prisma using 91 community-dwelling older participants (aged 82 years). Although we found considerable differences in absolute measurements (global tissue volumes were measured as ~6-11% higher and fractional anisotropy was 33% higher at 3T than at 1.5T), between-scanner consistency was good to excellent for global volumetric and dMRI measures (intraclass correlation coefficient [ICC] range: 0.612-0.993) and fair to good for 68 cortical regions (FreeSurfer) and cortical surface measures (mean ICC: 0.504-0.763). Between-scanner consistency was fair for dMRI measures of 12 major white matter tracts (mean ICC: 0.475-0.564), and the general factors of these tracts provided excellent consistency (ICC > 0.769). Whole-brain structural networks provided good to excellent consistency for global metrics (ICC > 0.612). Although consistency was poor for individual network connections (mean ICCs: 0.275-0.280), this was driven by a large difference in network sparsity (0.599 versus 0.334), and consistency was improved when comparing only the connections present in every participant (mean ICCs: 0.533-0.647). Regression-based k-fold cross-validation showed that, particularly for global volumes, between-scanner differences could be largely eliminated (R2 range 0.615-0.991). We conclude that low granularity measures of brain structure can be reliably matched between the scanners tested, but caution is warranted when combining high granularity information from different scanners.

scholarly journals Characterisation of an inflammation-related epigenetic score and its association with cognitive ability

2019 ◽  
Author(s):  
Anna J. Stevenson ◽  
Daniel L. McCartney ◽  
Robert F. Hillary ◽  
Archie Campbell ◽  
Stewart W. Morris ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Cognitive Ability ◽  
Chronic Inflammation ◽  
Birth Cohort ◽  
Large Scale ◽  
Acute Infection ◽  
Plasma Concentrations ◽  
Generation Scotland ◽  
Lothian Birth Cohort ◽  
Serum Crp

ABSTRACTResults from large cohort studies investigating the association between inflammation and cognition have been mixed, possibly due to methodological disparities. However, a key issue in research utilising inflammatory biomarkers is their typically phasic responses. C-reactive protein (CRP) is widely used to investigate the association between chronic inflammation and cognition, but its plasma concentrations can markedly deviate in response to acute infection. Recently a large-scale epigenome-wide association study identified DNA methylation correlates of CRP. DNA methylation is thought to be relatively stable in the short term, marking it as a potentially useful signature of exposure. Here, we generate an epigenetic CRP score and investigate its trajectories with age, and associations with cognitive ability, in comparison to serum CRP in two cohorts: a longitudinal study of older adults (the Lothian Birth Cohort 1936, n=889) and a large, cross-sectional cohort (Generation Scotland, n=7,028).We identified differing trajectories of serum CRP across the cohorts, with no homogeneous trends seen with age. Conversely, the epigenetic score was consistently found to increase with age, and to do so more rapidly in males compared to females. Higher levels of serum CRP were found to associate with poorer cognition in Lothian Birth Cohort 1936, but not in Generation Scotland. However, a consistent negative association was identified between cognition and the epigenetic score in both cohorts. Furthermore, the epigenetic score accounted for a greater proportion of variance in cognitive ability.Our results suggest that epigenetic signatures of acute inflammatory markers may provide an enhanced signature of chronic inflammation, allowing for more reliable stratification of individuals, and thus clearer inference of associations with incident health outcomes.

scholarly journals Longitudinal serum S100β and brain aging in the Lothian Birth Cohort 1936

2018 ◽  
Vol 69 ◽  
pp. 274-282 ◽  
Author(s):  
Simon R. Cox ◽  
Mike Allerhand ◽  
Stuart J. Ritchie ◽  
Susana Muñoz Maniega ◽  
Maria Valdés Hernández ◽  
...  
Keyword(s):  
Birth Cohort ◽  
Brain Aging ◽  
Lothian Birth Cohort

The association between cognitive ability across the lifespan and health literacy in old age: The Lothian Birth Cohort 1936

Intelligence ◽  
2011 ◽  
Vol 39 (4) ◽  
pp. 178-187 ◽  
Author(s):  
Catherine Murray ◽  
Wendy Johnson ◽  
Michael S. Wolf ◽  
Ian J. Deary
Keyword(s):  
Health Literacy ◽  
Cognitive Ability ◽  
Birth Cohort ◽  
Old Age ◽  
Lothian Birth Cohort
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