scholarly journals Emotion processing and regulation in major depressive disorder: A 7T resting‐state fMRI study

2020 ◽  
Author(s):  
Amir Ebneabbasi ◽  
Mostafa Mahdipour ◽  
Vahid Nejati ◽  
Meng Li ◽  
Thomas Liebe ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Resting State ◽  
Emotion Processing ◽  
Resting State Fmri ◽  
Major Depressive ◽  
Fmri Study

scholarly journals Emotion processing and regulation in major depressive disorder: A 7T resting-state fMRI study

2020 ◽  
Author(s):  
Amir Ebneabbasi ◽  
Mostafa Mahdipour ◽  
Vahid Nejati ◽  
Meng Li ◽  
Thomas Liebe ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Emotion Processing ◽  
Low Frequency ◽  
Resting State Fmri ◽  
Depression Severity ◽  
Major Depressive ◽  
Affective Symptoms ◽  
Regulatory Behavior ◽  
Fmri Study

Dysfunctions in bottom-up emotion processing (EP), as well as top-down emotion regulation (ER) are prominent features in pathophysiology of major depressive disorder (MDD). Nonetheless, it is not clear whether EP- and ER-related areas are regionally and/or connectively disturbed, and how they are interactively linked to abnormal affective symptoms of MDD. In this study, regional amplitude of low frequency fluctuations (ALFF) and whole-brain functional connectivity (FC) of meta-analytic-driven EP- and ER-related seeds were compared between 20 MDD patients and 32 healthy subjects. Then, we investigated whether the regulatory behavior can be predicted by the ALFF of EP-related seeds, and also whether this prediction is mediated by the ALFF of ER-related seeds. Finally, correlation between depression severity, ALFF and FC of EP- and ER-related seeds was assessed. We found that: (i) MDD is associated with regional/connectivity alterations of EP- and ER-related areas; (ii) the predictive relationship between elevated EP and weaker regulatory behavior is mediated by diminished ER in MDD; (iii) depression severity is correlated with FC of EP- and ER- related areas. Our findings shed new light on neural correlates of EP and ER in MDD.

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