scholarly journals Language lateralization from task‐based and resting state functional MRI in patients with epilepsy

2020 ◽  
Vol 41 (11) ◽  
pp. 3133-3146 ◽  
Author(s):  
Rachel Rolinski ◽  
Xiaozhen You ◽  
Javier Gonzalez‐Castillo ◽  
Gina Norato ◽  
Richard C. Reynolds ◽  
...  
Keyword(s):  
Functional Mri ◽  
Resting State ◽  
Language Lateralization ◽  
Patients With Epilepsy

scholarly journals Language lateralization with resting-state and task-based functional MRI in pediatric epilepsy

2019 ◽  
Vol 23 (2) ◽  
pp. 171-177 ◽  
Author(s):  
Virendra R. Desai ◽  
Aditya Vedantam ◽  
Sandi K. Lam ◽  
Lucia Mirea ◽  
Stephen T. Foldes ◽  
...  
Keyword(s):  
Functional Mri ◽  
Resting State ◽  
Pediatric Population ◽  
Intractable Epilepsy ◽  
Resting State Fmri ◽  
Hemispheric Dominance ◽  
Pediatric Epilepsy ◽  
Language Lateralization ◽  
The Right ◽  
And Task

OBJECTIVEDetermining language laterality in patients with intractable epilepsy is important in operative planning. Wada testing is the gold standard, but it has a risk of stroke. Both Wada and task-based functional MRI (tb-fMRI) require patient cooperation. Recently, resting-state fMRI (rs-fMRI) has been explored for language lateralization. In the present study, the correlation between rs-fMRI and tb-fMRI in language lateralization is estimated in a pediatric population with intractable epilepsy.METHODSrs-fMRI and tb-fMRI language lateralization testing performed as part of epilepsy surgery evaluation was retrospectively reviewed.RESULTSTwenty-nine patients underwent rs-fMRI and tb-fMRI; a total of 38 rs-fMRI studies and 30 tb-fMRI studies were obtained. tb-fMRI suggested left dominance in 25 of 30 cases (83%), right in 3 (10%), and in 2 (7%) the studies were nondiagnostic. In rs-fMRI, 26 of 38 studies (68%) suggested left dominance, 3 (8%) right dominance, 6 (16%) bilateral, and 3 (8%) were nondiagnostic. When tb-fMRI lateralized to the left hemisphere (25 cases), rs-fMRI was lateralized to the left in 23 patients (92%) and it was bilateral/equal in 2 (8%). When tb-fMRI lateralized to the right (3 cases), rs-fMRI lateralized to the right in all cases (100%). The overall concordance rate was 0.93 (95% CI 0.76–0.99) when considering cases with tb-fMRI and rs-fMRI performed within 6 months of each other, and tb-fMRI results were not nondiagnostic.CONCLUSIONSrs-fMRI significantly correlated with tb-fMRI in lateralizing language and suggests the potential role for identifying hemispheric dominance via rs-fMRI. Further investigation and validation studies are warranted.

scholarly journals Botulinum toxin injection changes resting state cerebellar connectivity in cervical dystonia

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Pavel Hok ◽  
Lenka Hvizdošová ◽  
Pavel Otruba ◽  
Michaela Kaiserová ◽  
Markéta Trnečková ◽  
...  
Keyword(s):  
Functional Mri ◽  
Resting State ◽  
Cervical Dystonia ◽  
Botulinum Neurotoxin ◽  
Botulinum Toxin Injection ◽  
Clinical Severity ◽  
Before And After ◽  
Positive Correlations ◽  
Using Data ◽  
The Right

AbstractIn cervical dystonia, functional MRI (fMRI) evidence indicates changes in several resting state networks, which revert in part following the botulinum neurotoxin A (BoNT) therapy. Recently, the involvement of the cerebellum in dystonia has gained attention. The aim of our study was to compare connectivity between cerebellar subdivisions and the rest of the brain before and after BoNT treatment. Seventeen patients with cervical dystonia indicated for treatment with BoNT were enrolled (14 female, aged 50.2 ± 8.5 years, range 38–63 years). Clinical and fMRI examinations were carried out before and 4 weeks after BoNT injection. Clinical severity was evaluated using TWSTRS. Functional MRI data were acquired on a 1.5 T scanner during 8 min rest. Seed-based functional connectivity analysis was performed using data extracted from atlas-defined cerebellar areas in both datasets. Clinical scores demonstrated satisfactory BoNT effect. After treatment, connectivity decreased between the vermis lobule VIIIa and the left dorsal mesial frontal cortex. Positive correlations between the connectivity differences and the clinical improvement were detected for the right lobule VI, right crus II, vermis VIIIb and the right lobule IX. Our data provide evidence for modulation of cerebello-cortical connectivity resulting from successful treatment by botulinum neurotoxin.

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