scholarly journals Understanding the impact of bilateral brain injury in children with unilateral cerebral palsy

2020 ◽  
Vol 41 (10) ◽  
pp. 2794-2807 ◽  
Author(s):  
Alex M. Pagnozzi ◽  
Kerstin Pannek ◽  
Jurgen Fripp ◽  
Simona Fiori ◽  
Roslyn N. Boyd ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Brain Injury ◽  
Unilateral Cerebral Palsy ◽  
The Impact

scholarly journals Identifying relevant biomarkers of brain injury from structural MRI: Validation using automated approaches in children with unilateral cerebral palsy

PLoS ONE ◽  
2017 ◽  
Vol 12 (8) ◽  
pp. e0181605 ◽  
Author(s):  
Alex M. Pagnozzi ◽  
Nicholas Dowson ◽  
James Doecke ◽  
Simona Fiori ◽  
Andrew P. Bradley ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Brain Injury ◽  
Structural Mri ◽  
Unilateral Cerebral Palsy

scholarly journals Optimization of MRI-based scoring scales of brain injury severity in children with unilateral cerebral palsy

2015 ◽  
Vol 46 (2) ◽  
pp. 270-279 ◽  
Author(s):  
Alex M. Pagnozzi ◽  
Simona Fiori ◽  
Roslyn N. Boyd ◽  
Andrea Guzzetta ◽  
James Doecke ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Brain Injury ◽  
Injury Severity ◽  
Unilateral Cerebral Palsy

scholarly journals Sensorimotor functional connectivity in unilateral cerebral palsy: influence of corticospinal tract wiring pattern and clinical correlates

2019 ◽  
Author(s):  
Cristina Simon-Martinez ◽  
Ellen Jaspers ◽  
Kaat Alaerts ◽  
Els Ortibus ◽  
Joshua Balsters ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Functional Connectivity ◽  
Upper Limb ◽  
Corticospinal Tract ◽  
Motor Deficits ◽  
Periventricular White Matter ◽  
Healthy Controls ◽  
Sensorimotor Network ◽  
Unilateral Cerebral Palsy ◽  
The Impact

ABSTRACTIn children with unilateral cerebral palsy (uCP), the corticospinal tract (CST) wiring patterns may differ (contralateral, ipsilateral or bilateral), partially determining motor deficits. However, the impact of such CST wiring on functional connectivity remains unknown. Here, we explored differences in functional connectivity of the resting-state sensorimotor network in 26 uCP with periventricular white matter lesions (mean age (SD): 12.87m (±4.5), CST wiring: 9 contralateral, 9 ipsilateral, 6 bilateral) compared to 60 healthy controls (mean age (SD): 14.54 (±4.8)), and between CST wiring patterns. Functional connectivity from each M1 to three bilateral sensorimotor regions of interest (primary sensory cortex, dorsal and ventral premotor cortex) and the supplementary motor area was compared between groups (healthy controls vs. uCP; and healthy controls vs. each CST wiring group). Results from the seed-to-voxel analyses from bilateral M1 were compared between groups. Additionally, relations with upper limb motor deficits were explored. Aberrant sensorimotor functional connectivity seemed to be CST-dependent rather than specific from all the uCP population: in the dominant hemisphere, the contralateral CST group showed increased connectivity between M1 and premotor cortices, whereas the bilateral CST group showed higher connectivity between M1 and somatosensory association areas. These results suggest that functional connectivity of the sensorimotor network is CST wiring-dependent, although the impact on upper limb function remains unclear.

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