scholarly journals Verbal insight revisited: fMRI evidence for early processing in bilateral insulae for solutions with AHA! experience shortly after trial onset

2019 ◽  
Vol 41 (1) ◽  
pp. 30-45 ◽  
Author(s):  
Maxi Becker ◽  
Tobias Sommer ◽  
Simone Kühn
Keyword(s):  
Trial Onset ◽  
Early Processing

scholarly journals Verbal Insight Revisited: fMRI evidence for early processing in bilateral insulae for solutions with AHA! experience shortly after trial onset

2019 ◽  
Author(s):  
Maxi Becker ◽  
Tobias Sommer ◽  
Simone Kühn
Keyword(s):  
Problem Solving ◽  
Semantic Priming ◽  
Brain Activity ◽  
Solution Process ◽  
Fmri Study ◽  
Trial Onset ◽  
Insight Problem Solving ◽  
Early Processing ◽  
Subliminal Processing

In insight problem solving solutions with AHA! experience have been assumed to be the consequence of restructuring of a problem which usually takes place shortly before the solution. However, evidence from priming studies suggests that solutions with AHA! are not spontaneously generated during the solution process but already relate to prior subliminal processing. We test this hypothesis by conducting an fMRI study using a modified compound remote associates paradigm which incorporates semantic priming. We observe stronger brain activity in bilateral anterior insulae already shortly after trial onset in problems that were later solved with than without AHA!. This early activity was independent of semantic priming but may be related to other lexical properties of attended words helping to reduce the amount of solutions to look for. In contrast, there was more brain activity in bilateral anterior insulae during solutions that were solved without than with AHA!. This timing (after trial start / during solution) x solution experience (with / without AHA!) interaction was significant.The results suggest that a) solutions accompanied with AHA! relate to early solution-relevant processing and b) both solution experiences differ in timing when solution-relevant processing takes place. In this context, we discuss the potential role of the anterior insula as part of the salience network involved in problem-solving by allocating attentional resources.

Effects of Experimentally Induced Pain on Mismatch Negativity

2006 ◽  
Vol 20 (1) ◽  
pp. 21-31 ◽  
Author(s):  
Bruce D. Dick ◽  
John F. Connolly ◽  
Michael E. Houlihan ◽  
Patrick J. McGrath ◽  
G. Allen Finley ◽  
...  
Keyword(s):  
Cognitive Processing ◽  
Mismatch Negativity ◽  
Event Related Potentials ◽  
Disruptive Effect ◽  
Ischemic Pain ◽  
Active Attention ◽  
Early Processing ◽  
Related Potentials ◽  
Healthy Participants ◽  
Experimentally Induced

Abstract: Previous research has found that pain can exert a disruptive effect on cognitive processing. This experiment was conducted to extend previous research with participants with chronic pain. This report examines pain's effects on early processing of auditory stimulus differences using the Mismatch Negativity (MMN) in healthy participants while they experienced experimentally induced pain. Event-related potentials (ERPs) were recorded using target and standard tones whose pitch differences were easy- or difficult-to-detect in conditions where participants attended to (active attention) or ignored (passive attention) the stimuli. Both attention manipulations were conducted in no pain and pain conditions. Experimentally induced ischemic pain did not disrupt the MMN. However, MMN amplitudes were larger to difficult-to-detect deviant tones during painful stimulation when they were attended than when they were ignored. Also, MMN amplitudes were larger to the difficult- than to the easy-to-detect tones in the active attention condition regardless of pain condition. It appears that rather than exerting a disruptive effect, the presence of experimentally induced pain enhanced early processing of small stimulus differences in these healthy participants.

Investigating the Multimodal Nature of Human Communication

2009 ◽  
Vol 23 (2) ◽  
pp. 63-76 ◽  
Author(s):  
Silke Paulmann ◽  
Sarah Jessen ◽  
Sonja A. Kotz
Keyword(s):  
Visual Information ◽  
Empirical Studies ◽  
Physical Property ◽  
Event Related Potentials ◽  
Accurate Information ◽  
Human Communication ◽  
Channel Condition ◽  
Prosodic Cues ◽  
Early Processing ◽  
Related Potentials

The multimodal nature of human communication has been well established. Yet few empirical studies have systematically examined the widely held belief that this form of perception is facilitated in comparison to unimodal or bimodal perception. In the current experiment we first explored the processing of unimodally presented facial expressions. Furthermore, auditory (prosodic and/or lexical-semantic) information was presented together with the visual information to investigate the processing of bimodal (facial and prosodic cues) and multimodal (facial, lexic, and prosodic cues) human communication. Participants engaged in an identity identification task, while event-related potentials (ERPs) were being recorded to examine early processing mechanisms as reflected in the P200 and N300 component. While the former component has repeatedly been linked to physical property stimulus processing, the latter has been linked to more evaluative “meaning-related” processing. A direct relationship between P200 and N300 amplitude and the number of information channels present was found. The multimodal-channel condition elicited the smallest amplitude in the P200 and N300 components, followed by an increased amplitude in each component for the bimodal-channel condition. The largest amplitude was observed for the unimodal condition. These data suggest that multimodal information induces clear facilitation in comparison to unimodal or bimodal information. The advantage of multimodal perception as reflected in the P200 and N300 components may thus reflect one of the mechanisms allowing for fast and accurate information processing in human communication.

scholarly journals Loading of Meiotic Cohesin by SCC-2 Is Required for Early Processing of DSBs and for the DNA Damage Checkpoint

2011 ◽  
Vol 21 (17) ◽  
pp. 1421-1430 ◽  
Author(s):  
James Lightfoot ◽  
Sarah Testori ◽  
Consuelo Barroso ◽  
Enrique Martinez-Perez
Keyword(s):  
Dna Damage ◽  
Dna Damage Checkpoint ◽  
Early Processing

When Feature Information Comes First! Early Processing of Inverted Faces

Perception ◽  
10.1068/p5192 ◽  
2005 ◽  
Vol 34 (9) ◽  
pp. 1117-1134 ◽  
Author(s):  
Claus-Christian Carbon ◽  
Helmut Leder
Keyword(s):  
Information Processing ◽  
Face Recognition ◽  
Face Processing ◽  
Contextual Information ◽  
Presentation Time ◽  
Early Processing ◽  
Feature Information ◽  
Short Presentation Time ◽  
Short Presentation

We investigated the early stages of face recognition and the role of featural and holistic face information. We exploited the fact that, on inversion, the alienating disorientation of the eyes and mouth in thatcherised faces is hardly detectable. This effect allows featural and holistic information to be dissociated and was used to test specific face-processing hypotheses. In inverted thatcherised faces, the cardinal features are already correctly oriented, whereas in undistorted faces, the whole Gestalt is coherent but all information is disoriented. Experiment 1 and experiment 3 revealed that, for inverted faces, featural information processing precedes holistic information. Moreover, the processing of contextual information is necessary to process local featural information within a short presentation time (26 ms). Furthermore, for upright faces, holistic information seems to be available faster than for inverted faces (experiment 2). These differences in processing inverted and upright faces presumably cause the differential importance of featural and holistic information for inverted and upright faces.

scholarly journals Purification, crystallization and preliminary X-ray diffraction analysis of Imp3 in complex with an Mpp10 peptide involved in yeast ribosome biogenesis

2014 ◽  
Vol 70 (7) ◽  
pp. 918-921 ◽  
Author(s):  
Sanduo Zheng ◽  
Keqiong Ye
Keyword(s):  
Diffraction Analysis ◽  
Associated Factors ◽  
Ribosome Biogenesis ◽  
X Ray Diffraction ◽  
Unit Cell Parameters ◽  
Vast Number ◽  
X Ray ◽  
Cell Parameters ◽  
Early Processing ◽  
Ribosomal Particle

Eukaryotic ribosome synthesis requires a vast number of transiently associated factors. Mpp10, Imp3 and Imp4 form a protein complex in the 90S pre-ribosomal particle that conducts early processing of 18S rRNA. Here, a short fragment of Mpp10 was identified to associate with and increase the solubility of Imp3. An Imp3–Mpp10 complex was co-expressed, co-purified and co-crystallized. Preliminary X-ray diffraction analysis revealed that the crystal diffracted to 2.1 Å resolution and belonged to space groupP212121, with unit-cell parametersa= 51.6,b= 86.9,c= 88.7 Å.

Magnetoencephalographic evidence of early processing of direction of gaze in humans

2001 ◽  
Vol 316 (3) ◽  
pp. 173-177 ◽  
Author(s):  
Margot J Taylor ◽  
Nathalie George ◽  
Antoine Ducorps
Keyword(s):  
Early Processing

scholarly journals Processing of prothrombin in the secretory pathway

1991 ◽  
Vol 277 (1) ◽  
pp. 59-65 ◽  
Author(s):  
C Stanton ◽  
R Taylor ◽  
R Wallin
Keyword(s):  
Golgi Apparatus ◽  
Secretory Pathway ◽  
Gradient Centrifugation ◽  
Serine Proteinase ◽  
Sucrose Density Gradient ◽  
Sucrose Density Gradient Centrifugation ◽  
Carboxylase Activity ◽  
Parent Molecule ◽  
Early Processing ◽  
In Cis

Antibodies raised against plasma prothrombin and the prothrombin propeptide were used to identify prothrombin precursors in rough and smooth microsomes and in the Golgi apparatus. The data demonstrate that the propeptide is part of the prothrombin molecule when undergoing a variety of modifications in the Golgi apparatus. It is shown that these modifications result in an increase in the apparent molecular mass of the prothrombin precursor from 78 kDa in early processing to 83 kDa in late processing. The 83 kDa prothrombin precursor was not recognized by the anti-propeptide antiserum and most likely represents the final product of the precursor in the secretory pathway. Evidence is presented that the propeptide is released from the parent molecule in the Golgi apparatus by a membrane-bound Ca(2+)-dependent serine proteinase(s) with characteristics similar to those of the proalbumin-to-albumin-converting enzyme. Vitamin K-dependent carboxylase activity was measured in membrane fragments obtained from the Golgi apparatus preparation. Sucrose-density-gradient centrifugation and the use of marker enzymes showed that carboxylase activity was highest in fractions enriched in cis-Golgi cisternae. Two different synthetic peptides were used as substrates for the carboxylase. These peptides were from the N-terminal and the C-terminal part of the gamma-carboxyglutamic acid (Gla) region of prothrombin. It is shown that the N-terminal and the C-terminal peptides were preferred as substrates for the carboxylase in the microsomal and the Golgi apparatus preparations respectively. It is also shown that the prothrombin precursor acquires negative charges in the Golgi apparatus that do not result from addition of sugars in late processing. These negative charges could be eliminated by thermal decarboxylation, suggesting that Gla residues may also be synthesized in late processing.

Bipolar or rectified chromatic detection mechanisms?

2001 ◽  
Vol 18 (1) ◽  
pp. 127-135 ◽  
Author(s):  
MARCEL J. SANKERALLI ◽  
KATHY T. MULLEN
Keyword(s):  
Color Vision ◽  
Masking Effect ◽  
Yellow Light ◽  
Detection Thresholds ◽  
Noise Masking ◽  
Human Color Vision ◽  
Early Processing ◽  
The Cross ◽  
On And Off Pathways ◽  
Luminance Increment

It is widely accepted that human color vision is based on two types of cone-opponent mechanism, one differencing L and M cone types (loosely termed “red–green”), and the other differencing S with the L and M cones (loosely termed “blue–yellow”). The traditional view of the early processing of human color vision suggests that each of these cone-opponent mechanisms respond in a bipolar fashion to signal two opponent colors (red vs. green, blue vs. yellow). An alternative possibility is that each cone-opponent response, as well as the luminance response, is rectified, so producing separable signals for each pole (red, green, blue, yellow, light, and dark). In this study, we use psychophysical noise masking to determine whether the rectified model applies to detection by the postreceptoral mechanisms. We measured the contrast-detection thresholds of six test stimuli (red, green, blue, yellow, light, and dark), corresponding to the two poles of each of the three postreceptoral mechanisms. For each test, we determined whether noise presented to the cross pole had the same masking effect as noise presented to the same pole (e.g. comparing masking of luminance increments by luminance decrement noise (cross pole) and luminance increment noise (same pole)). To avoid stimulus cancellation, the test and mask were presented asynchronously in a “sandwich” arrangement (mask-test-mask). For the six test stimuli, we observed that noise masks presented to the cross pole did not raise the detection thresholds of the test, whereas noise presented to the same pole produced a substantial masking. This result suggests that each color signal (red, green, blue, and yellow) and luminance signal (light and dark) is subserved by a separable mechanism. We suggest that the cone-opponent and luminance mechanisms have similar physiological bases, since a functional separation of the processing of cone increments and cone decrements could underlie both the separation of the luminance system into ON and OFF pathways as well as the splitting of the cone-opponent mechanisms into separable color poles.

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