scholarly journals Delineating functional segregations of the human middle temporal gyrus with resting‐state functional connectivity and coactivation patterns

2019 ◽  
Vol 40 (18) ◽  
pp. 5159-5171 ◽  
Author(s):  
Jinping Xu ◽  
Hanqing Lyu ◽  
Tian Li ◽  
Ziyun Xu ◽  
Xianjun Fu ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Middle Temporal Gyrus ◽  
Resting State Functional Connectivity ◽  
Middle Temporal

scholarly journals Aberrant Functional Connectivity in Resting State Networks of ADHD Patients Revealed by Independent Component Analysis(ICA)

2019 ◽  
Author(s):  
Huayu Zhang ◽  
Yue Zhao ◽  
Weifang Cao ◽  
Dong Cui ◽  
Qing Jiao ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Superior Temporal Gyrus ◽  
Middle Temporal Gyrus ◽  
Typically Developing ◽  
Middle Temporal ◽  
Group Ica ◽  
The Right ◽  
Brain Functional Connectivity ◽  
Left Middle Temporal Gyrus

Abstract Background：ADHD is one of the most common psychiatric disorders in children and adolescents. Altered functional connectivity has been associated with ADHD symptoms. This study aimed to investigate abnormal changes in the functional connectivity of resting-state brain networks (RSNs) among adolescent patients with different subtypes of ADHD. Methods: The data were obtained from the ADHD-200 Global Competition, including fMRI data from 88 ADHD patients (56 patients of ADHD-Combined，ADHD-C and 32 patients of ADHD-Inattentive, ADHD-I) and 67 Typically-Developing Controls (TD-C). Group ICA was utilized to research aberrant brain functional connectivity within different subtypes of ADHD. Results: Compared with TD-C group, the clusters of decreased functional connectivity were located in the left inferior occipital gyrus (p=0.0041) and right superior occipital gyrus (p=0.0011) of DAN, supplementary motor area (p=0.0036) of ECN, left supramarginal gyrus (p=0.0081) of SN, middle temporal gyrus (p=0.0041) and superior medial frontal gyrus (p=0.0055) of DMN in ADHD-C group. In the ADHD-I group, decreased functional connectivity was found in the right superior parietal gyrus (p=0.0017) of DAN and left middle temporal gyrus (p=0.0105) of DMN. The decreased functional connectivity of ADHD-C group was found in superior temporal gyrus (p=0.0062) of AN, inferior temporal gyrus (p=0.0016) of DAN, dorsolateral superior frontal gyrus (p=0.0082) of DMN compared to ADHD-I group. All the clusters surviving at p<0.05 (AlphaSim correction). Conclusion: The results suggested that decreased functional connectivity within the DMN and DAN was responsible, at least in part, for the symptom of inattention in ADHD-I patients. Similarly, we believed that the impaired functional connectivity within networks may contribute to the manifestations of ADHD-C patients, including inattention, hyperactivity/impulsivity, and unconscious movements.

scholarly journals An Exploratory Study on Resting-State Functional Connectivity in Individuals with Disorganized Attachment: Evidence for Key Regions in Amygdala and Hippocampus

2021 ◽  
Vol 11 (11) ◽  
pp. 1539
Author(s):  
Gianluca Cruciani ◽  
Maddalena Boccia ◽  
Vittorio Lingiardi ◽  
Guido Giovanardi ◽  
Pietro Zingaretti ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Middle Temporal Gyrus ◽  
Functional Coupling ◽  
Brain Abnormalities ◽  
Resting State Functional Connectivity ◽  
Posterior Portion ◽  
The Right

Studies comparing organized (O) and unresolved/disorganized (UD) attachment have consistently shown structural and functional brain abnormalities, although whether and how attachment patterns may affect resting state functional connectivity (RSFC) is still little characterized. Here, we investigated RSFC of temporal and limbic regions of interest for UD attachment. Participants’ attachment was classified via the Adult Attachment Interview, and all participants underwent clinical assessment. Functional magnetic resonance imaging data were collected from 11 UD individuals and seven matched O participants during rest. A seed-to-voxel analysis was performed, including the anterior and the posterior cingulate cortex, the bilateral insula, amygdala and hippocampus as seed regions. No group differences in the clinical scales emerged. Compared to O, the UD group showed lower RSFC between the left amygdala and the left cerebellum (lobules VIII), and lower functional coupling between the right hippocampus and the posterior portion of the right middle temporal gyrus. Moreover, UD participants showed higher RSFC between the right amygdala and the anterior cingulate cortex. Our findings suggest RSFC alterations in regions associated with encoding of salient events, emotion processing, memories retrieval and self-referential processing in UD participants, highlighting the potential role of attachment experiences in shaping brain abnormalities also in non-clinical UD individuals.

scholarly journals Insulin Resistance-Associated Interhemispheric Functional Connectivity Alterations in T2DM: A Resting-State fMRI Study

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Wenqing Xia ◽  
Shaohua Wang ◽  
Andrea M. Spaeth ◽  
Hengyi Rao ◽  
Pin Wang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Functional Connectivity ◽  
Resting State ◽  
Correlation Coefficients ◽  
Resting State Fmri ◽  
Brain Regions ◽  
Middle Temporal Gyrus ◽  
Model Assessment ◽  
Healthy Controls ◽  
Resting State Functional Connectivity

We aim to investigate whether decreased interhemispheric functional connectivity exists in patients with type 2 diabetes mellitus (T2DM) by using resting-state functional magnetic resonance imaging (rs-fMRI). In addition, we sought to determine whether interhemispheric functional connectivity deficits associated with cognition and insulin resistance (IR) among T2DM patients. We compared the interhemispheric resting state functional connectivity of 32 T2DM patients and 30 healthy controls using rs-fMRI. Partial correlation coefficients were used to detect the relationship between rs-fMRI information and cognitive or clinical data. Compared with healthy controls, T2DM patients showed bidirectional alteration of functional connectivity in several brain regions. Functional connectivity values in the middle temporal gyrus (MTG) and in the superior frontal gyrus were inversely correlated with Trail Making Test-B score of patients. Notably, insulin resistance (log homeostasis model assessment-IR) negatively correlated with functional connectivity in the MTG of patients. In conclusion, T2DM patients exhibit abnormal interhemispheric functional connectivity in several default mode network regions, particularly in the MTG, and such alteration is associated with IR. Alterations in interhemispheric functional connectivity might contribute to cognitive dysfunction in T2DM patients.

scholarly journals Aberrant functional connectivity in resting state networks of ADHD patients revealed by independent component analysis

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Huayu Zhang ◽  
Yue Zhao ◽  
Weifang Cao ◽  
Dong Cui ◽  
Qing Jiao ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Superior Temporal Gyrus ◽  
Middle Temporal Gyrus ◽  
Middle Temporal ◽  
Dorsal Attention Network ◽  
Group Ica ◽  
The Right ◽  
Brain Functional Connectivity ◽  
Left Middle Temporal Gyrus

Abstract Background ADHD is one of the most common psychiatric disorders in children and adolescents. Altered functional connectivity has been associated with ADHD symptoms. This study aimed to investigate abnormal changes in the functional connectivity of resting-state brain networks (RSNs) among adolescent patients with different subtypes of ADHD. Methods The data were obtained from the ADHD-200 Global Competition, including fMRI data from 88 ADHD patients (56 patients of ADHD-Combined, ADHD-C and 32 patients of ADHD-Inattentive, ADHD-I) and 67 typically developing controls (TD-C). Group ICA was utilized to research aberrant brain functional connectivity within the different subtypes of ADHD. Results In comparison with the TD-C group, the ADHD-C group showed clusters of decreased functional connectivity in the left inferior occipital gyrus (p = 0.0041) and right superior occipital gyrus (p = 0.0011) of the dorsal attention network (DAN), supplementary motor area (p = 0.0036) of the executive control network (ECN), left supramarginal gyrus (p = 0.0081) of the salience network (SN), middle temporal gyrus (p = 0.0041), and superior medial frontal gyrus (p = 0.0055) of the default mode network (DMN), while the ADHD-I group showed decreased functional connectivity in the right superior parietal gyrus (p = 0.0017) of the DAN and left middle temporal gyrus (p = 0.0105) of the DMN. In comparison with the ADHD-I group, the ADHD-C group showed decreased functional connectivity in the superior temporal gyrus (p = 0.0062) of the AN, inferior temporal gyrus (p = 0.0016) of the DAN, and the dorsolateral superior frontal gyrus (p = 0.0082) of the DMN. All the clusters surviving at p < 0.05 (AlphaSim correction). Conclusion The results suggested that decreased functional connectivity within the DMN and DAN was responsible, at least in part, for the symptom of inattention in ADHD-I patients. Similarly, we believed that the impaired functional connectivity within networks may contribute to the manifestations of ADHD-C patients, including inattention, hyperactivity/impulsivity, and unconscious movements.

scholarly journals Link-Level Functional Connectivity Neuroalterations in Autism Spectrum Disorder: A Developmental Resting-State fMRI Study

Diagnostics ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 32
Author(s):  
Lluis Borràs-Ferrís ◽  
Úrsula Pérez-Ramírez ◽  
David Moratal
Keyword(s):  
Autism Spectrum Disorder ◽  
Functional Connectivity ◽  
Resting State ◽  
Data Exchange ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Statistical Dependence ◽  
Middle Temporal Gyrus ◽  
Middle Temporal ◽  
Brain Functions

Autism spectrum disorder (ASD) is a neurological and developmental disorder whose late diagnosis is based on subjective tests. In seeking for earlier diagnosis, we aimed to find objective biomarkers via analysis of resting-state functional MRI (rs-fMRI) images obtained from the Autism Brain Image Data Exchange (ABIDE) database. Thus, we estimated brain functional connectivity (FC) between pairs of regions as the statistical dependence between their neural-related blood-oxygen-level-dependent (BOLD) signals. We compared FC of individuals with ASD and healthy controls, matched by age and intelligence quotient (IQ), and split into three age groups (50 children, 98 adolescents, and 32 adults), from a developmental perspective. After estimating the correlation, we observed hypoconnectivities in children and adolescents with ASD between regions belonging to the default mode network (DMN). Concretely, in children, FC decreased between the left middle temporal gyrus and right frontal pole (p = 0.0080), and between the left orbitofrontal cortex and right superior frontal gyrus (p = 0.0144). In adolescents, this decrease was observed between bilateral postcentral gyri (p = 0.0012), and between the right precuneus and right middle temporal gyrus (p = 0.0236). These results help to gain a better understanding of the involved regions on autism and its connection with the affected superior cognitive brain functions.

scholarly journals Resting State Functional Connectivity and Outcomes of Psychotherapies for Late-life Depression

2020 ◽  
Author(s):  
Nili Solomonov ◽  
Lindsay W. Victoria ◽  
Katharine Dunlop ◽  
Matteo Respino ◽  
Matthew Hoptman ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Rating Scale ◽  
Depression Scale ◽  
Late Life ◽  
Anterior Cingulate ◽  
Middle Temporal Gyrus ◽  
Late Life Depression ◽  
Resting State Functional Connectivity ◽  
Depressive Episodes

Background: Problem solving therapy (PST) and “Engage”, a reward-exposure” based therapy, are important treatment options for late-life depression, given modest efficacy of antidepressants in this disorder. Abnormal function of the reward and default mode networks has been observed during depressive episodes. This study examined whether resting state functional connectivity (rsFC) of reward and DMN circuitries is associated with treatment outcomes. Methods: Thirty-two older adults with major depression (mean age = 72.7) were randomized to 9-weeks of either PST or “Engage”. We assessed rsFC at baseline and Week 6. We placed seeds in three a priori regions of interest: subgenual cingulate (sgACC), dorsal anterior cingulate cortex (dACC), and nucleus accumbens (NAcc). Outcome measures included the Hamilton Depression Rating Scale (HAMD) and the Behavioral Activation for Depression Scale (BADS).Results: In both PST and “Engage”, higher rsFC between the sgACC and middle temporal gyrus at baseline was associated with greater improvement in depression severity (HAMD). Preliminary findings suggested that in “Engage” treated participants, lower rsFC between the dACC and DMPFC at baseline was associated with HAM-D improvement. Finally, in Engage only, increased rsFC from baseline to Week 6 between NAcc and Superior Parietal Cortex was associated with increased BADS scores.Conclusion: The results suggest that patients who present with higher rsFC between the sgACC and a structure within the DMN may benefit from behavioral psychotherapies for late life depression. ‘Engage’ may lead to increased rsFC within the reward system reflecting a reconditioning of the reward systems by reward exposure.

Role of habenula and amygdala dysfunction in Parkinson disease patients with punding

Neurology ◽  
2017 ◽  
Vol 88 (23) ◽  
pp. 2207-2215 ◽  
Author(s):  
Vladana Markovic ◽  
Federica Agosta ◽  
Elisa Canu ◽  
Alberto Inuggi ◽  
Igor Petrovic ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Parkinson Disease ◽  
Resting State ◽  
Inferior Frontal Gyrus ◽  
Cognitive Status ◽  
Disease Stage ◽  
Middle Temporal Gyrus ◽  
Contributory Factor ◽  
Healthy Controls ◽  
Resting State Functional Connectivity

Objective:To assess whether a functional dysregulation of the habenula and amygdala, as modulators of the reward brain circuit, contributes to Parkinson disease (PD) punding.Methods:Structural and resting-state functional MRI were obtained from 22 patients with PD punding, 30 patients with PD without any impulsive-compulsive behavior (ICB) matched for disease stage and duration, motor impairment, and cognitive status, and 30 healthy controls. Resting-state functional connectivity of the habenula and amygdala bilaterally was assessed using a seed-based approach. Habenula and amygdala volumes and cortical thickness measures were obtained.Results:Compared to both healthy controls and PD cases without any ICB (PD–no ICB), PD-punding patients showed higher functional connectivity of habenula and amygdala with thalamus and striatum bilaterally, and lower connectivity between bilateral habenula and left frontal and precentral cortices. In PD-punding relative to PD–no ICB patients, a lower functional connectivity between right amygdala and hippocampus was also observed. Habenula and amygdala volumes were not different among groups. PD-punding patients showed a cortical thinning of the left superior frontal and precentral gyri and right middle temporal gyrus and isthmus cingulate compared to healthy controls, and of the right inferior frontal gyrus compared to both controls and PD–no ICB patients.Conclusions:A breakdown of the connectivity among the crucial nodes of the reward circuit (i.e., habenula, amygdala, basal ganglia, frontal cortex) might be a contributory factor to punding in PD. This study provides potential instruments to detect and monitor punding in patients with PD.

scholarly journals Resting-state functional connectivity in women with PMDD

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Nicole Petersen ◽  
Dara G. Ghahremani ◽  
Andrea J. Rapkin ◽  
Steven M. Berman ◽  
Noor Wijker ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Functional Connectivity ◽  
Executive Control ◽  
Resting State ◽  
Luteal Phase ◽  
Middle Temporal Gyrus ◽  
Control Network ◽  
Permutation Testing ◽  
Resting State Functional Connectivity ◽  
Executive Control Network

Abstract Background Premenstrual dysphoric disorder (PMDD) is an understudied, debilitating disorder of women. Given evidence for prefrontal cortical and limbic dysfunction in PMDD, we compared intrinsic connectivity of the executive control network (ECN), default mode network (DMN), and amygdala in women with PMDD vs. controls. Methods Thirty-six women (18 PMDD, 18 control) participated in fMRI during the follicular and luteal phases of the menstrual cycle. At each time, resting-state functional connectivity was evaluated both before and after participants performed an emotion regulation task. The ECN was identified using independent components analysis, and connectivity of left and right amygdala seeds was also evaluated. Results Nonparametric permutation testing identified a cluster in the left middle temporal gyrus (MTG) with significantly stronger connectivity to the left ECN in women with PMDD vs. controls in all four fMRI sessions. Women with PMDD exhibited no difference in functional connectivity between menstrual cycle phases. Amygdala connectivity did not differ between the groups but differed significantly with menstrual phase, with left amygdala connectivity to cingulate cortex being significantly stronger during the follicular vs. luteal phase. Right amygdala connectivity to the middle frontal gyrus was also stronger during the follicular vs. luteal phase, with no group differences. These findings suggest that women with PMDD have different intrinsic network dynamics in the left executive control network compared to healthy controls.

scholarly journals Amplitude of Low-Frequency Fluctuations and Resting-State Functional Connectivity in Trait Positive Empathy: A Resting-State fMRI Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Tong Yue ◽  
Jia Zhao ◽  
Anguo Fu
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Positive Emotions ◽  
Negative Emotion ◽  
Low Frequency ◽  
Middle Temporal Gyrus ◽  
Resting State Functional Connectivity ◽  
Frequency Fluctuations ◽  
The Right ◽  
Left Middle

Positive empathy is the ability to share and understand the positive emotions of others. In recent years, although positive empathy has received more and more attention, trait positive empathy (TPE)-related spontaneous brain activity during the resting state has not been extensively explored. We used the amplitude of low-frequency fluctuations (ALFFs) and resting-state functional connectivity (RSFC) of the resting-state functional magnetic resonance imaging signal to explore TPE-associated brain regions. We found that higher TPE was associated with higher ALFFs in the right insula and lower ALFFs in the right subgenual cingulate (SGC), right dorsomedial prefrontal cortex (dmPFC), and right precuneus. RSFC analyses showed that higher functional connectivity between the right insula and left parahippocampal gyrus, left inferior parietal lobule and left middle temporal gyrus were related to higher TPE. Moreover, the connection between the right dmPFC and the left medial orbitofrontal cortex, left middle occipital gyrus and left posterior cingulate cortex were positively related to TPE. Meanwhile, the strength of functional connectivity between the right SGC and left supplementary motor area was positively associated with TPE. These findings may indicate that TPE is linked to emotional (especially the experience of more positive emotions and better negative emotion regulation) and self-referential processing.

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