scholarly journals Cerebral lesion correlates of sympathetic cardiovascular activation in multiple sclerosis

2019 ◽  
Vol 40 (17) ◽  
pp. 5083-5093 ◽  
Author(s):  
Klemens Winder ◽  
Ralf A. Linker ◽  
Frank Seifert ◽  
Ruihao Wang ◽  
De‐Hyung Lee ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebral Lesion

Cognitive decline in multiple sclerosis: impact of topographic lesion distribution on differential cognitive deficit patterns

2009 ◽  
Vol 15 (10) ◽  
pp. 1164-1174 ◽  
Author(s):  
L. Tiemann ◽  
IK Penner ◽  
M. Haupts ◽  
U. Schlegel ◽  
P. Calabrese
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Dysfunction ◽  
Cognitive Deficit ◽  
Memory Function ◽  
Third Ventricle ◽  
Minor Role ◽  
Cerebral Lesion ◽  
Lesion Load ◽  
Lesion Topography ◽  
Periventricular Lesions

Background: Multiple sclerosis (MS) is often accompanied by cognitive dysfunction. A negative correlation between cerebral lesion load and atrophy and cognitive performance has been pointed out almost consistently. Further, the distribution of lesions might be critical for the emergence of specific patterns of cognitive deficits. Objective: The current study evaluated the significance of total lesion area (TLA) and central atrophy for the prediction of general cognitive dysfunction and tested for a correspondence between lesion topography and specific cognitive deficit patterns. Methods: Thirty-seven patients with MS underwent neuropsychological assessment and magnetic resonance imaging. Lesion burden and central atrophy were quantified. Patients were classified into three groups by means of individual lesion topography (punctiform lesions/periventricular lesions/confluencing lesions in both periventricular and extra-periventricular regions). Results: TLA was significantly related to 7 cognitive variables, whereas third ventricle width was significantly associated with 20 cognitive parameters. The three groups differed significantly in their performances on tasks concerning alertness, mental speed, and memory function. Conclusion: Third ventricle width as a straight-forward measure of central atrophy proved to be of substantial predictive value for cognitive dysfunction, whereas total lesion load played only a minor role. Periventricular located lesions were significantly related to decreased psychomotor speed, whereas equally distributed cerebral lesion load did not. These findings support the idea that periventricular lesions have a determinant impact on cognition in patients with MS.

scholarly journals Diffuse Axonal and Tissue Injury in Patients With Multiple Sclerosis With Low Cerebral Lesion Load and No Disability

2002 ◽  
Vol 59 (10) ◽  
pp. 1565 ◽  
Author(s):  
Nicola De Stefano ◽  
Sridar Narayanan ◽  
Simon J. Francis ◽  
Steve Smith ◽  
Marzia Mortilla ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Tissue Injury ◽  
Cerebral Lesion ◽  
Lesion Load

scholarly journals An MRI-defined measure of cerebral lesion severity to assess therapeutic effects in multiple sclerosis

2016 ◽  
Vol 263 (3) ◽  
pp. 531-538 ◽  
Author(s):  
Gloria Kim ◽  
Shahamat Tauhid ◽  
Sheena L. Dupuy ◽  
Subhash Tummala ◽  
Fariha Khalid ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Therapeutic Effects ◽  
Cerebral Lesion ◽  
Lesion Severity

Influence of cerebral lesion volume and lesion distribution on event-related brain potentials in multiple sclerosis

2001 ◽  
Vol 248 (12) ◽  
pp. 1049-1055 ◽  
Author(s):  
M. Sailer ◽  
H. J. Heinze ◽  
I. Tendolkar ◽  
U. Decker ◽  
O. Kreye ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Lesion Volume ◽  
Cerebral Lesion ◽  
Brain Potentials

Microglia-derived macrophages in early multiple sclerosis plaques

1996 ◽  
Vol 22 (3) ◽  
pp. 207-215 ◽  
Author(s):  
H. Li ◽  
M. L. Cuzner ◽  
J. Newcombe
Keyword(s):  
Multiple Sclerosis
Sign in / Sign up

Export Citation Format

Share Document