scholarly journals Neurochemical correlates of scene processing in the precuneus/posterior cingulate cortex: A multimodal fMRI and 1 H-MRS study

2019 ◽  
Vol 40 (10) ◽  
pp. 2884-2898 ◽  
Author(s):  
Alison G. Costigan ◽  
Katja Umla-Runge ◽  
C. John Evans ◽  
Carl J. Hodgetts ◽  
Andrew D. Lawrence ◽  
...  
Keyword(s):  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Posterior Cingulate ◽  
Scene Processing ◽  
Neurochemical Correlates

scholarly journals Neurochemical correlates of scene processing in the precuneus/posterior cingulate cortex: a multimodal fMRI and 1H-MRS study

2018 ◽  
Author(s):  
Alison G. Costigan ◽  
Katja Umla-Runge ◽  
C. John Evans ◽  
Carl J. Hodgetts ◽  
Andrew D. Lawrence ◽  
...  
Keyword(s):  
Individual Differences ◽  
Region Of Interest ◽  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Situation Models ◽  
1H Mrs ◽  
Posterior Cingulate ◽  
Brain Metabolite ◽  
Fmri Analysis ◽  
Neurochemical Correlates

AbstractPrecuneus/posterior cingulate cortex (PCu/PCC) are key components of a midline network, activated during rest but also in tasks that involve construction of scene or situation models. Despite growing interest in PCu/PCC functional alterations in disease, the underlying neurochemical modulators of PCu/PCC’s task-induced activity are largely unstudied. Here, a multimodal imaging approach was applied to investigate whether inter-individual differences in PCu/PCC fMRI activity, elicited during perceptual discrimination of scene stimuli, were correlated with local brain metabolite levels, measured during resting-state 1H-MRS. Forty healthy young adult participants (12 male) completed an fMRI perceptual odd-one-out task for scenes, objects and faces. 1H-MRS metabolites N-acetyl-aspartate (tNAA), glutamate (Glx) and γ-amino-butyric acid (GABA+) were quantified via PRESS and MEGA-PRESS scans in a PCu/PCC voxel and an occipital (OCC) control voxel. Whole brain fMRI revealed a cluster in right dorsal PCu/PCC that showed a greater BOLD response to scenes versus faces and objects. When extracted from an independently defined PCu/PCC region of interest, scene activity (versus faces and objects and also versus baseline) was positively correlated with PCu/PCC, but not OCC, tNAA. A complementary fMRI analysis restricted to the PCu/PCC MRS voxel area identified a significant PCu/PCC cluster, confirming the positive correlation between scene-related BOLD activity and PCu/PCC tNAA. There were no correlations between PCu/PCC fMRI activity and Glx or GABA+ levels. These results demonstrate, for the first time, that scene activity in PCu/PCC is linked to local tNAA levels, identifying a neurochemical influence on inter-individual differences in the task-driven activity of a key brain hub.

Serum Vitamin D and Cingulate Cortex Thickness in Older Adults: Quantitative MRI of the Brain

2019 ◽  
Vol 16 (11) ◽  
pp. 1063-1071 ◽  
Author(s):  
Gonzague Foucault ◽  
Guillaume T Duval ◽  
Romain Simon ◽  
Olivier Beauchet ◽  
Mickael Dinomais ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Brain Mri ◽  
Serum Vitamin ◽  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Vitamin D Insufficiency ◽  
Anterior Cingulate ◽  
Posterior Cingulate ◽  
Significant Difference

Background: Vitamin D insufficiency is associated with brain changes, and cognitive and mobility declines in older adults. Method: Two hundred and fifteen Caucasian older community-dwellers (mean±SD, 72.1±5.5years; 40% female) received a blood test and brain MRI. The thickness of perigenual anterior cingulate cortex, midcingulate cortex and posterior cingulate cortex was measured using FreeSurfer from T1-weighted MR images. Age, gender, education, BMI, mean arterial pressure, comorbidities, use of vitamin D supplements or anti-vascular drugs, MMSE, GDS, IADL, serum calcium and vitamin B9 concentrations, creatinine clearance were used as covariables. Results: Participants with vitamin D insufficiency (n=80) had thinner total cingulate thickness than the others (24.6±1.9mm versus 25.3±1.4mm, P=0.001); a significant difference found for all 3 regions. Vitamin D insufficiency was cross-sectionally associated with a decreased total cingulate thickness (β=- 0.49, P=0.028). Serum 25OHD concentration correlated positively with the thickness of perigenual anterior (P=0.011), midcingulate (P=0.013) and posterior cingulate cortex (P=0.021). Conclusion: Vitamin D insufficiency was associated with thinner cingulate cortex in the studied sample of older adults. These findings provide insight into the pathophysiology of cognitive and mobility declines in older adults with vitamin D insufficiency.

scholarly journals Long-term Chinese calligraphic handwriting reshapes the posterior cingulate cortex: A VBM study

PLoS ONE ◽  
2019 ◽  
Vol 14 (4) ◽  
pp. e0214917
Author(s):  
Wen Chen ◽  
Chuansheng Chen ◽  
Pin Yang ◽  
Suyu Bi ◽  
Jin Liu ◽  
...  
Keyword(s):  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Posterior Cingulate

scholarly journals HIV Distal Neuropathic Pain Is Associated with Smaller Ventral Posterior Cingulate Cortex

Pain Medicine ◽  
2016 ◽  
pp. pnw180 ◽  
Author(s):  
John R. Keltner ◽  
Colm G. Connolly ◽  
Florin Vaida ◽  
Mark Jenkinson ◽  
Christine Fennema-Notestine ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Posterior Cingulate

scholarly journals Correlation between Traits of Emotion-Based Impulsivity and Intrinsic Default-Mode Network Activity

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Jizheng Zhao ◽  
Dardo Tomasi ◽  
Corinde E. Wiers ◽  
Ehsan Shokri-Kojori ◽  
Şükrü B. Demiral ◽  
...  
Keyword(s):  
Brain Activity ◽  
Low Frequency ◽  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Anterior Cingulate ◽  
Network Activity ◽  
High Risk Behaviors ◽  
Posterior Cingulate ◽  
Healthy Humans ◽  
Dorsolateral Prefrontal

Negative urgency (NU) and positive urgency (PU) are implicated in several high-risk behaviors, such as eating disorders, substance use disorders, and nonsuicidal self-injury behavior. The current study aimed to explore the possible link between trait of urgency and brain activity at rest. We assessed the amplitude of low-frequency fluctuations (ALFF) of the resting-state functional magnetic resonance imaging (fMRI) signal in 85 healthy volunteers. Trait urgency measures were related to ALFF in the lateral orbitofrontal cortex, dorsolateral prefrontal cortex, ventral and dorsal medial frontal cortex, anterior cingulate, and posterior cingulate cortex/precuneus. In addition, trait urgency measures showed significant correlations with the functional connectivity of the posterior cingulate cortex/precuneus seed with the thalamus and midbrain region. These findings suggest an association between intrinsic brain activity and impulsive behaviors in healthy humans.

Quantitative cytoarchitectonics of the posterior cingulate cortex in primates

1986 ◽  
Vol 253 (4) ◽  
pp. 514-524 ◽  
Author(s):  
Karl Zilles ◽  
Este Armstrong ◽  
Gottfried Schlaug ◽  
Axel Schleicher
Keyword(s):  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Posterior Cingulate ◽  
Quantitative Cytoarchitectonics

[IC-P-149]: LACK OF SELF-AWARENESS OF COGNITIVE DEFICITS IN ALZHEIMER's DISEASE IS RELATED TO DECREASED METABOLISM IN THE POSTERIOR CINGULATE CORTEX

2017 ◽  
Vol 13 (7S_Part_2) ◽  
pp. P112-P113
Author(s):  
Joseph Therriault ◽  
Tharick A. Pascoal ◽  
Kok Pin Ng ◽  
Sulantha S. Mathotaarachchi ◽  
Min Su Kang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Deficits ◽  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Self Awareness ◽  
Posterior Cingulate
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