scholarly journals Brain network dynamics in schizophrenia: Reduced dynamism of the default mode network

2019 ◽  
Vol 40 (7) ◽  
pp. 2212-2228 ◽  
Author(s):  
Akhil Kottaram ◽  
Leigh A. Johnston ◽  
Luca Cocchi ◽  
Eleni P. Ganella ◽  
Ian Everall ◽  
...  
Keyword(s):  
Default Mode Network ◽  
Network Dynamics ◽  
Brain Network ◽  
Default Mode

scholarly journals Altered Default Mode Network Dynamics in Civil Aviation Pilots

2020 ◽  
Vol 13 ◽  
Author(s):  
Xi Chen ◽  
Kaijun Xu ◽  
Yong Yang ◽  
Quanchuan Wang ◽  
Hao Jiang ◽  
...  
Keyword(s):  
Default Mode Network ◽  
Network Dynamics ◽  
Civil Aviation ◽  
Default Mode ◽  
Aviation Pilots

Assessment of Graph Metrics and Lateralization of Brain Connectivity in Progression of Alzheimer's Disease Using fMRI

2017 ◽  
Vol 9 (4) ◽  
pp. 46-66 ◽  
Author(s):  
Bhuvaneshwari Bhaskaran ◽  
Kavitha Anandan
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Default Mode Network ◽  
Brain Connectivity ◽  
Brain Network ◽  
Brain Disorder ◽  
Default Mode ◽  
Graph Metrics ◽  
Functional Topology ◽  
The Brain

Alzheimer's disease (AD) is a progressive brain disorder which has a long preclinical phase. The beta-amyloid plaques and tangles in the brain are considered as the main pathological causes. Functional connectivity is typically examined in capturing brain network dynamics in AD. A definitive underconnectivity is observed in patients through the progressive stages of AD. Graph theoretic modeling approaches have been effective in understanding the brain dynamics. In this article, the brain connectivity patterns and the functional topology through the progression of Alzheimer's disease are analysed using resting state fMRI. The altered network topology is analysed by graphed theoretical measures and explains cognitive deficits caused by the progression of this disease. Results show that the functional topology is disrupted in the default mode network regions as the disease progresses in patients. Further, it is observed that there is a lack of left lateralization involving default mode network regions as the severity in AD increases.

scholarly journals Beyond Feeling: Chronic Pain Hurts the Brain, Disrupting the Default-Mode Network Dynamics

2008 ◽  
Vol 28 (6) ◽  
pp. 1398-1403 ◽  
Author(s):  
M. N. Baliki ◽  
P. Y. Geha ◽  
A. V. Apkarian ◽  
D. R. Chialvo
Keyword(s):  
Chronic Pain ◽  
Default Mode Network ◽  
Network Dynamics ◽  
Default Mode ◽  
The Brain

scholarly journals Frequency Specific Effects of ApoE ε4 Allele on Resting-State Networks in Nondemented Elders

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Ying Liang ◽  
Zhenzhen Li ◽  
Jing Wei ◽  
Chunlin Li ◽  
Xu Zhang ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Frequency Band ◽  
Default Mode Network ◽  
Resting State ◽  
Brain Network ◽  
Salience Network ◽  
Default Mode ◽  
Specific Effects ◽  
Network Time ◽  
Time Courses

We applied resting-state functional magnetic resonance imaging (fMRI) to examine the Apolipoprotein E (ApoE) ε4 allele effects on functional connectivity of the default mode network (DMN) and the salience network (SN). Considering the frequency specific effects of functional connectivity, we decomposed the brain network time courses into two bands: 0.01–0.027 Hz and 0.027–0.08 Hz. All scans were acquired by the Alzheimer’s Disease Neuroscience Initiative (ADNI). Thirty-two nondemented subjects were divided into two groups based on the presence (n=16) or absence (n=16) of the ApoE ε4 allele. We explored the frequency specific effects of ApoE ε4 allele on the default mode network (DMN) and the salience network (SN) functional connectivity. Compared to ε4 noncarriers, the DMN functional connectivity of ε4 carriers was significantly decreased while the SN functional connectivity of ε4 carriers was significantly increased. Many functional connectivities showed significant differences at the lower frequency band of 0.01–0.027 Hz or the higher frequency band of 0.027–0.08 Hz instead of the typical range of 0.01–0.08 Hz. The results indicated a frequency dependent effect of resting-state signals when investigating RSNs functional connectivity.

scholarly journals Symptoms of fatigue and depression is reflected in altered default mode network connectivity in multiple sclerosis

2018 ◽  
Author(s):  
Einar August Høgestøl ◽  
Gro Owren Nygaard ◽  
Dag Alnæs ◽  
Mona K. Beyer ◽  
Lars T. Westlye ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Default Mode Network ◽  
Symptom Burden ◽  
Network Connectivity ◽  
Principal Component ◽  
Brain Network ◽  
Common Symptom ◽  
Linear Regression Models ◽  
Default Mode ◽  
Network Function

Background: Fatigue and depression are frequent and often co-occurring symptoms in multiple sclerosis (MS). Resting-state functional magnetic resonance imaging (rs-fMRI) represents a promising tool for disentangling differential associations between depression and fatigue and brain network function and connectivity. In this study we tested for associations between symptoms of fatigue and depression and DMN connectivity in patients with MS. Materials and methods: Seventy-four MS patients were included on average 14 months after diagnosis. They underwent MRI scanning of the brain including rs-fMRI, and symptoms of fatigue and depression were assessed with Fatigue Severity Scale (FSS) and Beck Depression Inventory II (BDI). A principal component analysis (PCA) on FSS and BDI scores was performed, and the component scores were analysed using linear regression models to test for associations with default mode network (DMN) connectivity. Results: We observed higher DMN connectivity with higher scores on the primary principal component reflecting common symptom burden for fatigue and depression (Cohen's f2=0.075, t=2.17, p=0.03). The secondary principal component reflecting a pattern of low fatigue scores with high scores of depression was associated with lower DMN connectivity (Cohen's f2=0.067, t=-2.1, p=0.04). Using continuous mean scores of FSS we also observed higher DMN connectivity with higher symptom burden (t=3.1, p=0.003), but no significant associations between continuous sum scores of BDI and DMN connectivity (t=0.8, p=0.4). Conclusion: Multivariate decomposition of FSS and BDI data supported both overlapping and unique manifestation of fatigue and depression in MS patients. Rs-fMRI analyses showed that symptoms of fatigue and depression was reflected in altered DMN connectivity, and that higher DMN activity was seen in MS patients with fatigue even with low depression scores.

scholarly journals Large-scale brain networks and Freudian ego

2019 ◽  
Vol 12 (2) ◽  
pp. 162-175 ◽  
Author(s):  
Petar Radoev Dimkov
Keyword(s):  
Sigmund Freud ◽  
Default Mode Network ◽  
Large Scale ◽  
Structural Model ◽  
Brain Network ◽  
Default Mode ◽  
Current Thinking ◽  
Theoretical Hypothesis ◽  
Brain Correlates ◽  
The Brain

Sigmund Freud, the founder of psychoanalysis, is predominantly known for his conception of the id, ego and super-ego, representing a part of his meta-psychology of the psychic apparatus. Nowadays, with the advancements in technology and science, his meta-psychological structural model of the psyche might be either confirmed or denied by comparing the account of the psychic apparatus of the classical psychoanalysis to the newest findings in neuropsychology and cognitive neuroscience. Indeed, the founded interdisciplinary project of neuro-psychoanalysis strives to answer such questions. In this article, the current thinking on the discussions around Freudian ego and its possible brain correlates is presented. In 2010, Robin Carhart-Harris and Karl Friston introduced a neuro-psychoanalytic account of the psychic apparatus, where the ego correlated with a large-scale brain network called the default-mode network. In the end of this paper, an original theoretical hypothesis is offered, supplemented with review of the literature, namely that the central-executive network and the salience network are viewed as the true representatives of Freudian ego. The offered hypothesis criticizes Carhart-Harris and Friston’s postulating of the default-mode network as being the brain representative of Freudian ego.

scholarly journals Default mode network dynamics in covert consciousness

Cortex ◽  
2019 ◽  
Vol 119 ◽  
pp. 571-574 ◽  
Author(s):  
Yelena G. Bodien ◽  
Zachary D. Threlkeld ◽  
Brian L. Edlow
Keyword(s):  
Default Mode Network ◽  
Network Dynamics ◽  
Default Mode

Assessment of Graph Metrics and Lateralization of Brain Connectivity in Progression of Alzheimer's Disease Using fMRI

2021 ◽  
pp. 589-610
Author(s):  
Bhuvaneshwari Bhaskaran ◽  
Kavitha Anandan
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Default Mode Network ◽  
Brain Connectivity ◽  
Brain Network ◽  
Brain Disorder ◽  
Default Mode ◽  
Graph Theoretic ◽  
Functional Topology ◽  
The Brain

Alzheimer's disease (AD) is a progressive brain disorder which has a long preclinical phase. The beta-amyloid plaques and tangles in the brain are considered as the main pathological causes. Functional connectivity is typically examined in capturing brain network dynamics in AD. A definitive underconnectivity is observed in patients through the progressive stages of AD. Graph theoretic modeling approaches have been effective in understanding the brain dynamics. In this article, the brain connectivity patterns and the functional topology through the progression of Alzheimer's disease are analysed using resting state fMRI. The altered network topology is analysed by graphed theoretical measures and explains cognitive deficits caused by the progression of this disease. Results show that the functional topology is disrupted in the default mode network regions as the disease progresses in patients. Further, it is observed that there is a lack of left lateralization involving default mode network regions as the severity in AD increases.

scholarly journals Segregation between the parietal memory network and the default mode network: Effects of spatial smoothing and model order in ICA

2016 ◽  
Author(s):  
Yang Hu ◽  
Jijun Wang ◽  
Chunbo Li ◽  
Yin-shan Wang ◽  
Zhi Yang ◽  
...  
Keyword(s):  
Default Mode Network ◽  
Network Effects ◽  
Posterior Cingulate Cortex ◽  
Brain Network ◽  
Parameter Determination ◽  
Spatial Smoothing ◽  
Model Order ◽  
Default Mode ◽  
Memory Network ◽  
Group Ica

AbstractA brain network consisting of two key parietal nodes, the precuneus and the posterior cingulate cortex, has emerged from recent fMRI studies. Though it is anatomically adjacent to and spatially overlaps with the default mode network (DMN), its function has been associated with memory processing, and it has been referred to as the parietal memory network (PMN). Independent component analysis (ICA) is the most common data-driven method of extracting PMN and DMN simultaneously. However, the effects of data preprocessing and parameter determination in ICA on PMN-DMN segregation are completely unknown. Here, we employ three typical algorithms of group ICA to assess how spatial smoothing and model order influence the degree of PMN-DMN segregation. Our findings indicate that PMN and DMN can only be stably separated using a combination of low-level spatial smoothing and high-order model across the three ICA algorithms. We thus argue for more considerations on parametric settings for interpreting DMN data.

scholarly journals Aberrant posterior superior temporal sulcus functional connectivity and executive dysfunction in adolescents with internet gaming disorder

2020 ◽  
Vol 9 (3) ◽  
pp. 589-597
Author(s):  
Junghan Lee ◽  
Deokjong Lee ◽  
Kee Namkoong ◽  
Young-Chul Jung
Keyword(s):  
Functional Connectivity ◽  
Default Mode Network ◽  
Large Scale ◽  
Internet Gaming Disorder ◽  
Executive Dysfunction ◽  
Brain Network ◽  
Salience Network ◽  
Gaming Disorder ◽  
Default Mode ◽  
Internet Gaming

AbstractBackground and aimsThe clinical significance of Internet gaming disorder (IGD) is spreading worldwide, but its underlying neural mechanism still remains unclear. Moreover, the prevalence of IGD seems to be the highest in adolescents whose brains are in development. This study investigated the functional connectivity between large-scale intrinsic networks including default mode network, executive control network, and salience network. We hypothesized that adolescents with IGD would demonstrate different functional connectivity patterns among large-scale intrinsic networks, implying neurodevelopmental alterations, which might be associated with executive dysfunction.MethodsThis study included 17 male adolescents with Internet gaming disorder, and 18 age-matched male adolescents as healthy controls. Functional connectivity was examined using seed-to-voxel analysis and seed-to-seed analysis, with the nodes of large-scale intrinsic networks used as region of interests. Group independent component analysis was performed to investigate spatially independent network.ResultsWe identified aberrant functional connectivity of salience network and default mode network with the left posterior superior temporal sulcus (pSTS) in adolescents with IGD. Furthermore, functional connectivity between salience network and pSTS correlated with proneness to Internet addiction and self-reported cognitive problems. Independent component analysis revealed that pSTS was involved in social brain network.Discussion and conclusionsThe results imply that aberrant functional connectivity of social brain network with default mode network and salience network was identified in IGD that may be associated with executive dysfunction. Our results suggest that inordinate social stimuli during excessive online gaming leads to altered connections among large-scale networks during neurodevelopment of adolescents.

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