scholarly journals Spatiotemporal, metabolic, and therapeutic characterization of altered functional connectivity in major depressive disorder

2018 ◽  
Vol 39 (5) ◽  
pp. 1957-1971 ◽  
Author(s):  
Jintao Sheng ◽  
Yuedi Shen ◽  
Yanhua Qin ◽  
Lei Zhang ◽  
Binjia Jiang ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Functional Connectivity ◽  
Depressive Disorder ◽  
Major Depressive

scholarly journals Deep phenotyping of attention impairments and the ‘Inattention Biotype’ in Major Depressive Disorder

2019 ◽  
Vol 50 (13) ◽  
pp. 2203-2212 ◽  
Author(s):  
Arielle S. Keller ◽  
Tali M. Ball ◽  
Leanne M. Williams
Keyword(s):  
Major Depressive Disorder ◽  
Selective Attention ◽  
Depressive Disorder ◽  
Large Scale ◽  
Performance Measure ◽  
Behavioral Measure ◽  
Major Depressive ◽  
Attention Impairment ◽  
Attention Impairments

AbstractBackgroundAttention impairment is an under-investigated feature and diagnostic criterion of Major Depressive Disorder (MDD) that is associated with poorer outcomes. Despite increasing knowledge regarding mechanisms of attention in healthy adults, we lack a detailed characterization of attention impairments and their neural signatures in MDD.MethodsHere, we focus on selective attention and advance a deep multi-modal characterization of these impairments in MDD, using data acquired from n = 1008 patients and n = 336 age- and sex-matched healthy controls. Selective attention impairments were operationalized and anchored in a behavioral performance measure, assessed within a battery of cognitive tests. We sought to establish the accompanying neural signature using independent measures of functional magnetic resonance imaging (15% of the sample) and electroencephalographic recordings of oscillatory neural activity.ResultsGreater impairment on the behavioral measure of selective attention was associated with intrinsic hypo-connectivity of the fronto-parietal attention network. Not only was this relationship specific to the fronto-parietal network unlike other large-scale networks; this hypo-connectivity was also specific to selective attention performance unlike other measures of cognition. Selective attention impairment was also associated with lower posterior alpha (8–13 Hz) power at rest and was related to more severe negative bias (frequent misidentifications of neutral faces as sad and lingering attention on sad faces), relevant to clinical features of negative attributions and brooding. Selective attention impairments were independent of overall depression severity and of worrying or sleep problems.ConclusionsThese results provide a foundation for the clinical translational development of objective markers and targeted therapeutics for attention impairment in MDD.

scholarly journals Aberrant intrinsic functional connectivity in thalamo-cortical networks in major depressive disorder

2018 ◽  
Vol 24 (11) ◽  
pp. 1063-1072 ◽  
Author(s):  
Qing-Mei Kong ◽  
Hong Qiao ◽  
Chao-Zhong Liu ◽  
Ping Zhang ◽  
Ke Li ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Functional Connectivity ◽  
Depressive Disorder ◽  
Cortical Networks ◽  
Major Depressive ◽  
Intrinsic Functional Connectivity

scholarly journals Disrupted Brain Entropy And Functional Connectivity Patterns Of Thalamic Subregions In Major Depressive Disorder

2019 ◽  
Vol Volume 15 ◽  
pp. 2629-2638 ◽  
Author(s):  
Shao-Wei Xue ◽  
Donglin Wang ◽  
Zhonglin Tan ◽  
Yan Wang ◽  
Zhenzhen Lian ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Functional Connectivity ◽  
Depressive Disorder ◽  
Major Depressive ◽  
Connectivity Patterns ◽  
Brain Entropy
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