scholarly journals The relationship between thalamic GABA content and resting cortical rhythm in neuropathic pain

2018 ◽  
Vol 39 (5) ◽  
pp. 1945-1956 ◽  
Author(s):  
Flavia Di Pietro ◽  
Paul M. Macey ◽  
Caroline D. Rae ◽  
Zeynab Alshelh ◽  
Vaughan G. Macefield ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Cortical Rhythm ◽  
Gaba Content ◽  
The Relationship

scholarly journals Investigation of the Correlation between Postherpetic Itch and Neuropathic Pain over Time

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Rie Ishikawa ◽  
Masako Iseki ◽  
Rie Koga ◽  
Eiichi Inada
Keyword(s):  
Neuropathic Pain ◽  
Herpes Zoster ◽  
Pain Intensity ◽  
Visual Analog Scale ◽  
Analog Scale ◽  
Paindetect Questionnaire ◽  
Relationship Of ◽  
The Relationship ◽  
Over Time

Postherpetic itch (PHI), or herpes zoster itch, is an intractable and poorly understood disease. We targeted 94 herpes zoster patients to investigate their pain and itch intensities at three separate stages of the condition (acute, subacute, and chronic). We used painDETECT questionnaire (PDQ) scores to investigate the correlation between PHI and neuropathic pain. Seventy-six patients were able to complete follow-up surveys. The prevalence of PHI was 47/76 (62%), 28/76 (37%), and 34/76 (45%) at the acute, subacute, and chronic stages, respectively. PHI manifestation times and patterns varied. We investigated the relationship of PHI with neuropathic pain using the visual analog scale (VAS), which is a measure of pain intensity, and the PDQ, which is a questionnaire used to evaluate the elements of neuropathic pain. The VAS and PDQ scores did not differ significantly between PHI-positive and PHI-negative patients. A large neuropathic component was not found for herpes zoster itch, suggesting that neuropathic pain treatments may not able to adequately control the itch. Accordingly, we suggest that a more PHI-focused therapy is required to address this condition.

scholarly journals Src Family Kinases in the Central Nervous System：Their Emerging Role in Pathophysiology of Migraine and Neuropathic Pain

2020 ◽  
Vol 18 ◽  
Author(s):  
Lingdi Nie ◽  
Wen-Rui Ye ◽  
Shangbin Chen ◽  
Domenico Chirchiglia ◽  
Minyan Wang
Keyword(s):  
Neuropathic Pain ◽  
Tyrosine Kinases ◽  
Neurological Diseases ◽  
Src Family Kinases ◽  
Signalling Pathways ◽  
Pain Mechanisms ◽  
Promising Therapeutic Target ◽  
The Central Nervous System ◽  
The Relationship

: Src family kinases (SFK) are a group of non-receptor tyrosine kinases which play a pivotal role in cellular responses and oncogenesis. Accumulating evidence suggest that SFK also act as a key component in signalling pathways of the central nervous system (CNS) in both physiological and pathological conditions. Despite the crucial role of SFK in signal transduction of the CNS, the relationship between SFK and molecules implicated in pain has been relatively unexplored. This article briefly reviews the recent advances uncovering the interplay of SFK with diverse membrane proteins and intracellular proteins in the CNS and the importance of SFK in the pathophysiology of migraine and neuropathic pain. Mechanisms underlying the role of SFK in these conditions and potential clinical applications of SFK inhibitors in neurological diseases are also summarised. We propose that SFK are the convergent point of signalling pathways in migraine and neuropathic pain and may constitute a promising therapeutic target for these diseases.

scholarly journals Sleep Characteristics in Diabetic Patients Depending on the Occurrence of Neuropathic Pain and Related Factors

2020 ◽  
Vol 17 (21) ◽  
pp. 8125
Author(s):  
Cristina Naranjo ◽  
María Dueñas ◽  
Carlos Barrera ◽  
Guillermo Moratalla ◽  
Inmaculada Failde
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Neuropathic Pain ◽  
Sleep Quality ◽  
Depression Scale ◽  
Anxiety And Depression ◽  
Diabetic Patients ◽  
The Relationship

This study aims to compare the sleep characteristics (structure and quality) in patients with type-2 diabetes mellitus with and without diabetic neuropathic pain (DNP), and to investigate the relationship of sensory phenotypes, anxiety, and depression with sleep quality in DNP patients. A cross-sectional study was performed in patients with type-2 diabetes mellitus and neuropathy. Patients were classified into two groups—with or without neuropathic pain—according to the “Douleur Neuropathique-4 (DN4)” scale. Sleep characteristics and quality (Medical Outcomes Study—MOS-sleep), pain phenotype (Neuropathic Pain Symptom Inventory—NPSI), mood status (Hospital Anxiety and Depression scale—HADS), pain intensity (Visual Analogue Scale—VAS), and quality of life (SF-12v2) were measured. The sample included 130 patients (65 with DNP). The mean scores in all the dimensions of the MOS-sleep scale were higher (more disturbances) in the DNP patients. Higher scores in anxiety or depression, greater intensity of pain or a higher score in the paroxysmal pain phenotype were associated with lower sleep quality in DNP patients. A shorter duration of the diabetes and lower levels of glycated hemoglobin were also associated with lower sleep quality. The results show the relationship between DNP and sleep quality, and the importance of assessing sensory phenotypes and mental comorbidities in these patients. Taking these factors into consideration, to adopt a multimodal approach is necessary to achieve better clinical results.

Neuropathic Pain, Depression, and Cardiovascular Disease: A National Multicenter Study

2015 ◽  
Vol 44 (3) ◽  
pp. 130-137 ◽  
Author(s):  
Jacquelyn J. Cragg ◽  
Vanessa K. Noonan ◽  
Luc Noreau ◽  
Jaimie F. Borisoff ◽  
John K. Kramer
Keyword(s):  
Cardiovascular Disease ◽  
Neuropathic Pain ◽  
Self Report ◽  
Secondary Complications ◽  
Cross Sectional ◽  
Increased Risk ◽  
Cord Injury ◽  
Emerging Risk ◽  
Potential Factors ◽  
The Relationship

Background: Individuals with spinal cord injury (SCI) have a more than twofold increased risk of heart disease and stroke compared with able-bodied individuals. The increased risk appears to be in excess of the risk conferred by several well-established risk factors, including diabetes, hypertension, and sex. This raises the question whether other factors, secondary to SCI, are also contributing to the development of cardiovascular disease (CVD). Two potential factors associated with SCI and CVD are pain and depression. Both are frequently reported among individuals with SCI, develop in the acute stages of injury, and are commonly described as severe. Therefore, the primary aim of this study was to examine the relationship between pain (and types of pain) and depression with CVD among individuals with SCI. Methods: A total of 1,493 individuals (referred sample) with chronic SCI participated in a self-report cross-sectional multicenter Canada-wide survey from 2011-2012 (mean age ± standard deviation: 49.6 ± 13.9 years). Results: After adjustment for age, sex, and injury characteristics, neuropathic pain and depression were significantly and independently associated with CVD (adjusted odds ratio and 95% confidence interval: 2.27 (1.21, 4.60) for neuropathic pain; 4.07 (2.10, 7.87) for depression). In contrast to neuropathic pain, non-neuropathic pain was not significantly associated with CVD (p = 0.13). Conclusion: In conclusion, these data illustrate important interrelationships between secondary complications following SCI, as well as raise the possibility of neuropathic pain (versus nociceptive pain) as a novel and emerging risk factor for CVD.

scholarly journals The Usefulness of Diffusion Tensor Tractography in Diagnosing Neuropathic Pain: A Narrative Review

2021 ◽  
Vol 15 ◽  
Author(s):  
Seoyon Yang ◽  
SuYeon Kwon ◽  
Min Cheol Chang
Keyword(s):  
Neuropathic Pain ◽  
Brain Injuries ◽  
Diffusion Tensor ◽  
Diffusion Tensor Tractography ◽  
Pathophysiological Mechanism ◽  
Inclusion Criteria ◽  
Pathophysiological Process ◽  
Pubmed Search ◽  
The Relationship ◽  
Potential Use

Diffusion tensor tractography (DTT) is derived from diffusion tensor imaging. It has allowed visualization and estimation of neural tract injury, which may be associated with the pathogenesis of neuropathic pain (NP). The aim of the present study was to review DTT studies that demonstrated the relationship between neural injuries and NP and to describe the potential use of DTT in the evaluation of neural injuries that are involved in the pathophysiological process of NP. A PubMed search was conducted for articles published until July 3, 2020, which used DTT to investigate the association between neural injuries and NP. The key search phrase for identifying potentially relevant articles was (diffusion tensor tractography AND pain). The following inclusion criteria were applied for article selection: (1) studies involving patients with NP and (2) studies in which DTT was applied for the evaluation of NP. Review articles were excluded. Altogether, 108 potentially relevant articles were identified. After reading the titles and abstracts and assessment of eligibility based on the full-text articles, 46 publications were finally included in our review. The results of the included studies suggested that DTT may be beneficial in identifying the pathophysiological mechanism of NP of various origins including central pain caused by brain injuries, trigeminal neuralgia, sciatica, and some types of headache. Further studies are needed to validate the efficacy of DTT in investigating the pathophysiology of other types of NP.

scholarly journals The structure, nature and intensity of painin various forms of external genital endometriosis

2016 ◽  
Vol 65 (2) ◽  
pp. 24-30 ◽  
Author(s):  
Tatiana O Efimenko
Keyword(s):  
Neuropathic Pain ◽  
Pain Intensity ◽  
Nociceptive Pain ◽  
Visual Analogue Scale Pain ◽  
Ovarian Cysts ◽  
Microsoft Excel ◽  
Analogue Scale Pain ◽  
Severe Degree ◽  
Relationship Of ◽  
The Relationship

Background. The study of the relationship of severity of endometriosis, localization and intensity of pelvic pain is a significant scientific interest. Aim of the study was to determine the structure of pain in women with external genital endometriosis (EGE) varying forms of distribution. Materials and methods. 124 patients were examined. Degree exam proliferation was assessed by endoscopy. Recovered: superficial endometriosis; endometrioid ovarian cysts; infiltrative forms of endometriosis; combined forms of endometriosis. Pain intensity was determined in accordance with a 10-point visual-analogue scale. Pain Detect scale was used to determine the nature of the pain. Statistical analysis of the material was carried out using the Microsoft Excel 2013 (Microsoft Corp., USA) applications and Stastistica 10.0 for Windows. Results. Light degree of pain intensity in patients with superficial forms EGE (92.11 %, 35 cases) is 21 times higher than that in patients with infiltrative forms (4.35 %, 1 case). Severe degree of pain intensity and with the same frequency is found at infiltrative (56.52 %, 13 cases), combined forms of endometriosis (57.14 %, 8 cases) and in patients with bilateral endometrioid cysts (47.37 %, 9 cases). Nociceptive pain is typical for patients with superficial forms EGE (73.68 %, 28 cases). Neuropathic pain occurs 4.5 times more frequently in patients with infiltrative (86.96 %, 20 cases) and combined forms of endometriosis (92.86 %, 13 cases). Conclusions. Light degree of pain intensity corresponds to the surface form of endometriosis, moderate and severe degree of pain equally common in infiltrative forms and endometrioid ovarian cysts, severe degree of intensity of the most common in infiltrative endometriosis and associated forms. By the nature of pain in superficial forms of endometriosis is dominated by complaints typical for nociceptive pain, neuropathic pain is more common in infiltrative endometriosis and associated forms.

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