scholarly journals Analysis of family‐wise error rates in statistical parametric mapping using random field theory

2017 ◽  
Vol 40 (7) ◽  
pp. 2052-2054 ◽  
Author(s):  
Guillaume Flandin ◽  
Karl J. Friston
Keyword(s):  
Field Theory ◽  
Random Field ◽  
Statistical Parametric Mapping ◽  
Error Rates ◽  
Random Field Theory ◽  
Parametric Mapping

scholarly journals Statistical multiscale mapping of IDH1, MGMT, and microvascular proliferation in human brain tumors from multiparametric MR and spatially-registered core biopsy

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Jason G. Parker ◽  
Emily E. Diller ◽  
Sha Cao ◽  
Jeremy T. Nelson ◽  
Kristen Yeom ◽  
...  
Keyword(s):  
Field Theory ◽  
Random Field ◽  
Classification Accuracy ◽  
Core Biopsy ◽  
Gaussian Random Field ◽  
Error Rates ◽  
Molecular Heterogeneity ◽  
K Nearest Neighbor ◽  
Random Field Theory ◽  
Microvascular Proliferation

AbstractWe propose a statistical multiscale mapping approach to identify microscopic and molecular heterogeneity across a tumor microenvironment using multiparametric MR (mp-MR). Twenty-nine patients underwent pre-surgical mp-MR followed by MR-guided stereotactic core biopsy. The locations of the biopsy cores were identified in the pre-surgical images using stereotactic bitmaps acquired during surgery. Feature matrices mapped the multiparametric voxel values in the vicinity of the biopsy cores to the pathologic outcome variables for each patient and logistic regression tested the individual and collective predictive power of the MR contrasts. A non-parametric weighted k-nearest neighbor classifier evaluated the feature matrices in a leave-one-out cross validation design across patients. Resulting class membership probabilities were converted to chi-square statistics to develop full-brain parametric maps, implementing Gaussian random field theory to estimate inter-voxel dependencies. Corrections for family-wise error rates were performed using Benjamini-Hochberg and random field theory, and the resulting accuracies were compared. The combination of all five image contrasts correlated with outcome (P < 10−4) for all four microscopic variables. The probabilistic mapping method using Benjamini-Hochberg generated statistically significant results (α ≤ 0.05) for three of the four dependent variables: (1) IDH1, (2) MGMT, and (3) microvascular proliferation, with an average classification accuracy of 0.984 ± 0.02 and an average classification sensitivity of 1.567% ± 0.967. The images corrected by random field theory demonstrated improved classification accuracy (0.989 ± 0.008) and classification sensitivity (5.967% ± 2.857) compared with Benjamini-Hochberg. Microscopic and molecular tumor properties can be assessed with statistical confidence across the brain from minimally-invasive, mp-MR.

Unified univariate and multivariate random field theory

NeuroImage ◽  
2004 ◽  
Vol 23 ◽  
pp. S189-S195 ◽  
Author(s):  
Keith J. Worsley ◽  
Jonathan E. Taylor ◽  
Francesco Tomaiuolo ◽  
Jason Lerch
Keyword(s):  
Field Theory ◽  
Random Field ◽  
Random Field Theory ◽  
Multivariate Random Field
Sign in / Sign up

Export Citation Format

Share Document