scholarly journals The cerebellum shrinks faster than normal ageing in Alzheimer's disease but not in mild cognitive impairment

2017 ◽  
Vol 38 (6) ◽  
pp. 3141-3150 ◽  
Author(s):  
Hossein Tabatabaei-Jafari ◽  
Erin Walsh ◽  
Marnie E. Shaw ◽  
Nicolas Cherbuin ◽  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Normal Ageing

scholarly journals A multicentre longitudinal study of flortaucipir (18F) in normal ageing, mild cognitive impairment and Alzheimer’s disease dementia

Brain ◽  
2019 ◽  
Vol 142 (6) ◽  
pp. 1723-1735 ◽  
Author(s):  
Michael J Pontecorvo ◽  
Michael D Devous ◽  
Ian Kennedy ◽  
Michael Navitsky ◽  
Ming Lu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Longitudinal Study ◽  
Normal Ageing ◽  
Alzheimer’S Disease Dementia

scholarly journals Neurophysiological and brain structural markers of cognitive frailty differs from Alzheimer’s disease

2021 ◽  
Author(s):  
Ece Kocagoncu ◽  
David Nesbitt ◽  
Tina Emery ◽  
Laura Hughes ◽  
Richard N. Henson ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Healthy Aging ◽  
Grey Matter ◽  
Grey Matter Volume ◽  
Cognitive Frailty ◽  
Clinical Presentations ◽  
Normal Ageing

AbstractWith increasing life span, there is growing importance of understanding the mechanisms of successful cognitive ageing. In contrast, cognitive frailty has been proposed to be a precursor to Alzheimer’s disease. Here we test the hypothesis that cognitively frail adults represent a branch of healthy ageing, distinct from latent dementia. We used electro-magnetoencephalography and magnetic resonance imaging to investigate the structural and neurophysiological features of cognitive frailty in relation to healthy aging, and clinical presentations of mild cognitive impairment and Alzheimer’s disease. Cognitive performance of the cognitively frail group was similar to those with mild cognitive impairment. We used a novel cross-modal oddball task to induce mismatch responses to unexpected stimuli. Both controls and cognitively frail showed stronger mismatch responses and larger temporal grey matter volume, compared to people with mild cognitive impairment and Alzheimer’s disease. Our results suggest that cognitively frail represents a spectrum of normal ageing rather than incipient or undiagnosed Alzheimer’s disease. Lower cognitive reserve, hearing impairment and medical comorbidity might contribute to the aetiology of cognitive impairment.

scholarly journals MicroRNA Expression Signature in Mild Cognitive Impairment Due to Alzheimer’s Disease

2020 ◽  
Vol 57 (11) ◽  
pp. 4408-4416
Author(s):  
Bruna De Felice ◽  
Concetta Montanino ◽  
Mariano Oliva ◽  
Simona Bonavita ◽  
Valeria Di Onofrio ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Target Genes ◽  
Statistical Significance ◽  
Target Prediction ◽  
Normal Ageing ◽  
Set Up

Abstract Mild cognitive impairment (MCI) defines an intermediate state between normal ageing and dementia, including Alzheimer’s disease (AD). Identification of MCI subjects who will progress to AD (MCI-AD) is today of crucial importance, especially in light of the possible development of new pathogenic therapies. Several evidences suggest that miRNAs could play relevant roles in the biogenesis of AD, and the links between selected miRNAs and specific pathogenic aspects have been partly explored. In this study, we analysed the composition of microRNA transcriptome in blood, serum and cerebrospinal fluid samples from MCI-AD subjects, from an enriched small RNA library. Real-time qPCR from MCI-AD and AD patients and normal controls was performed to profile miRNA expression. In particular, four microRNAs, hsa-mir-5588-5p, hsa-mir-3658, hsa-mir-567 and hsa-mir-3908, among all selected microRNAs, are dysregulated. Hsa-mir-567 was found to be differentially expressed in cerebrospinal fluid samples, blood and serum from MCI-AD patients, showing the highest fold change and statistical significance. Target prediction analysis have been performed to evaluate mRNAs whose expression was controlled by miRNAs found to be dysregulated here, showing that hsa-mir-567 target genes are functionally active in neuronal cells. We propose that miRNA profiles found in samples from MCI-AD patients might be relevant for a better understanding of AD-related cognitive decline and could lead to set up suitable and potential biomarkers for MCI-AD progression to AD.

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