scholarly journals Local gyrification index in patients with major depressive disorder and its association with tryptophan hydroxylase-2 (TPH2 ) polymorphism

2016 ◽  
Vol 38 (3) ◽  
pp. 1299-1310 ◽  
Author(s):  
Kyu-Man Han ◽  
Eunsoo Won ◽  
June Kang ◽  
Aram Kim ◽  
Ho-Kyoung Yoon ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Tryptophan Hydroxylase ◽  
Tryptophan Hydroxylase 2 ◽  
Major Depressive ◽  
Gyrification Index ◽  
Local Gyrification Index

Tryptophan hydroxylase 2 gene is associated with major depressive disorder in a female Chinese population

2011 ◽  
Vol 133 (3) ◽  
pp. 619-624 ◽  
Author(s):  
Shen Xinhua ◽  
Wu Yanfeng ◽  
Qian Mingcai ◽  
Wang Xiaoquan ◽  
Hou Zhenghua ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Chinese Population ◽  
Tryptophan Hydroxylase ◽  
Tryptophan Hydroxylase 2 ◽  
Major Depressive

scholarly journals Altered Local Gyrification Index and Corresponding Functional Connectivity in Medication Free Major Depressive Disorder

2020 ◽  
Vol 11 ◽  
Author(s):  
Jiang Long ◽  
Jinping Xu ◽  
Xue Wang ◽  
Jin Li ◽  
Shan Rao ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Functional Connectivity ◽  
Depressive Disorder ◽  
Disease Onset ◽  
Depression Symptoms ◽  
Structural Abnormality ◽  
Precentral Gyrus ◽  
Major Depressive ◽  
Gyrification Index ◽  
Local Gyrification Index

A lot of previous studies have documented that major depressive disorder (MDD) is a developmental disorder. The cortical surface measure, local gyrification index (LGI), can well reflect the fetal and early postnatal neurodevelopmental processes. Thus, LGI may provide new insight for the neuropathology of MDD. The previous studies only focused on the surface structural abnormality, but how the structural abnormality lead to functional connectivity changes is unexplored. In this study, we investigated LGI and corresponding functional connectivity difference in 28 medication-free MDD patients. We found significantly decreased LGI in left lingual gyrus (LING) and right posterior superior temporal sulcus (bSTS), and the changed LGI in bSTS was negatively correlated with disease onset age and anxiety scores. The following functional connectivity analyses identified decreased functional connectivities between LING and right LING, precentral gyrus, and middle temporal gyrus. The decreased functional connectivities were correlated with disease duration, onset, and depression symptoms. Our findings revealed abnormal LGI in LING and bSTS indicating that the abnormal developmental of visual and social cognition related brain areas may be an early biomarker for depression.

Characterisation of three polymorphisms of the tryptophan hydroxylase 2 gene in a sample of Colombian population with major depressive disorder

2017 ◽  
Vol 46 (1) ◽  
pp. 22-30
Author(s):  
Adriana Martínez-Idárraga ◽  
Irene Riveros-Barrera ◽  
Ricardo Sánchez ◽  
Luis Eduardo Jaramillo ◽  
José Manuel Calvo-Gómez ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Tryptophan Hydroxylase ◽  
Tryptophan Hydroxylase 2 ◽  
Major Depressive
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