scholarly journals Parkinson's disease-related network topographies characterized with resting state functional MRI

2016 ◽  
Vol 38 (2) ◽  
pp. 617-630 ◽  
Author(s):  
An Vo ◽  
Wataru Sako ◽  
Koji Fujita ◽  
Shichun Peng ◽  
Paul J. Mattis ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Mri ◽  
Resting State

scholarly journals The Relationship between Side of Onset and Cerebral Regional Homogeneity in Parkinson’s Disease: A Resting-State fMRI Study

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Kai Li ◽  
Hong Zhao ◽  
Chun-Mei Li ◽  
Xin-Xin Ma ◽  
Min Chen ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Mri ◽  
Resting State ◽  
Brain Activity ◽  
Regional Homogeneity ◽  
Depression And Anxiety ◽  
Significant Difference ◽  
Temporal Pole ◽  
The Right

Objective. Motor symptoms are usually asymmetric in Parkinson’s disease (PD), and asymmetry in PD may involve widespread brain areas. We sought to evaluate the effect of asymmetry on the whole brain spontaneous activity using the measure regional homogeneity (ReHo) through resting-state functional MRI. Methods. We recruited 30 PD patients with left onset (LPD), 27 with right side (RPD), and 32 controls with satisfactory data. Their demographic, clinical, and neuropsychological information were obtained. Resting-state functional MRI was performed, and ReHo was used to determine the brain activity. ANCOVA was utilized to analyze between-group differences in ReHo and the associations between abnormal ReHo, and various clinical and neuropsychological variables were explored by Spearman’s correlation. Results. LPD patients had higher ReHo in the right temporal pole than the controls. RPD patients had increased ReHo in the right temporal pole and decreased ReHo in the primary motor cortex and premotor area, compared with the controls. Directly comparing LPD and RPD patients did not show a significant difference in ReHo. ReHo of the right temporal pole was significantly correlated with depression and anxiety in RPD patients. Conclusions. Both LPD and RPD have increased brain activity synchronization in the right temporal pole, and only RPD has decreased brain activity synchronization in the right frontal motor areas. The changed brain activity in the right temporal pole may play a compensatory role for depression and anxiety in PD, and the altered cerebral function in the right frontal motor area in RPD may represent the reorganization of the motor system in RPD.

scholarly journals Network degeneration in Parkinson’s disease: multimodal imaging of nigro-striato-cortical dysfunction

Brain ◽  
2020 ◽  
Vol 143 (3) ◽  
pp. 944-959 ◽  
Author(s):  
Marina C Ruppert ◽  
Andrea Greuel ◽  
Masoud Tahmasian ◽  
Frank Schwartz ◽  
Sophie Stürmer ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Connectivity ◽  
Functional Mri ◽  
Resting State ◽  
Fdg Pet ◽  
Multimodal Imaging ◽  
Substantia Nigra Pars Compacta ◽  
Dopamine Depletion ◽  
18F Fdg

Abstract The spreading hypothesis of neurodegeneration assumes an expansion of neural pathologies along existing neural pathways. Multimodal neuroimaging studies have demonstrated distinct topographic patterns of cerebral pathologies in neurodegeneration. For Parkinson’s disease the hypothesis so far rests largely on histopathological evidence of α-synuclein spreading in a characteristic pattern and progressive nigrostriatal dopamine depletion. Functional consequences of nigrostriatal dysfunction on cortical activity remain to be elucidated. Our goal was to investigate multimodal imaging correlates of degenerative processes in Parkinson’s disease by assessing dopamine depletion and its potential effect on striatocortical connectivity networks and cortical metabolism in relation to parkinsonian symptoms. We combined 18F-DOPA-PET, 18F-fluorodeoxyglucose (FDG)-PET and resting state functional MRI to multimodally characterize network alterations in Parkinson’s disease. Forty-two patients with mild-to-moderate stage Parkinson’s disease and 14 age-matched healthy control subjects underwent a multimodal imaging protocol and comprehensive clinical examination. A voxel-wise group comparison of 18F-DOPA uptake identified the exact location and extent of putaminal dopamine depletion in patients. Resulting clusters were defined as seeds for a seed-to-voxel functional connectivity analysis. 18F-FDG metabolism was compared between groups at a whole-brain level and uptake values were extracted from regions with reduced putaminal connectivity. To unravel associations between dopaminergic activity, striatocortical connectivity, glucose metabolism and symptom severity, correlations between normalized uptake values, seed-to-cluster β-values and clinical parameters were tested while controlling for age and dopaminergic medication. Aside from cortical hypometabolism, 18F-FDG-PET data for the first time revealed a hypometabolic midbrain cluster in patients with Parkinson’s disease that comprised caudal parts of the bilateral substantia nigra pars compacta. Putaminal dopamine synthesis capacity was significantly reduced in the bilateral posterior putamen and correlated with ipsilateral nigral 18F-FDG uptake. Resting state functional MRI data indicated significantly reduced functional connectivity between the dopamine depleted putaminal seed and cortical areas primarily belonging to the sensorimotor network in patients with Parkinson’s disease. In the inferior parietal cortex, hypoconnectivity in patients was significantly correlated with lower metabolism (left P = 0.021, right P = 0.018). Of note, unilateral network alterations quantified with different modalities corresponded with contralateral motor impairments. In conclusion, our results support the hypothesis that degeneration of nigrostriatal fibres functionally impairs distinct striatocortical connections, disturbing the efficient interplay between motor processing areas and impairing motor control in patients with Parkinson’s disease. The present study is the first to reveal trimodal evidence for network-dependent degeneration in Parkinson’s disease by outlining the impact of functional nigrostriatal pathway impairment on striatocortical functional connectivity networks and cortical metabolism.

scholarly journals Parkinson's Disease—Related Spatial Covariance Pattern Identified with Resting-State Functional MRI

2015 ◽  
Vol 35 (11) ◽  
pp. 1764-1770 ◽  
Author(s):  
Tao Wu ◽  
Yilong Ma ◽  
Zheng Zheng ◽  
Shichun Peng ◽  
Xiaoli Wu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Mri ◽  
Neural Activity ◽  
Resting State ◽  
Healthy Controls ◽  
Sample Analysis ◽  
Spatial Covariance ◽  
Control Subjects ◽  
Split Sample

In this study, we sought to identify a disease-related spatial covariance pattern of spontaneous neural activity in Parkinson's disease using resting-state functional magnetic resonance imaging (MRI). Time-series data were acquired in 58 patients with early to moderate stage Parkinson's disease and 54 healthy controls, and analyzed by Scaled Subprofile Model Principal Component Analysis toolbox. A split-sample analysis was also performed in a derivation sample of 28 patients and 28 control subjects and validated in a prospective testing sample of 30 patients and 26 control subjects. The topographic pattern of neural activity in Parkinson's disease was characterized by decreased activity in the striatum, supplementary motor area, middle frontal gyrus, and occipital cortex, and increased activity in the thalamus, cerebellum, precuneus, superior parietal lobule, and temporal cortex. Pattern expression was elevated in the patients compared with the controls, with a high accuracy (90%) to discriminate the patients from the controls. The split-sample analysis produced a similar pattern but with a lower accuracy for group discrimination in both the derivation (80%) and the validation (73%) samples. Our results showed that resting-state functional MRI can be potentially useful for identification of Parkinson's disease–related spatial covariance patterns, and for differentiation of Parkinson's disease patients from healthy controls at an individual level.

scholarly journals Parkinson's disease-related pattern (PDRP) identified using resting-state functional MRI: Validation study

2021 ◽  
Vol 1 (3) ◽  
pp. 100026
Author(s):  
Andrea Rommal ◽  
An Vo ◽  
Katharina A. Schindlbeck ◽  
Andrea Greuel ◽  
Marina C. Ruppert ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Mri ◽  
Validation Study ◽  
Resting State ◽  
Related Pattern

scholarly journals Resting state functional MRI in Parkinson’s disease: the impact of deep brain stimulation on ‘effective’ connectivity

Brain ◽  
2014 ◽  
Vol 137 (4) ◽  
pp. 1130-1144 ◽  
Author(s):  
Joshua Kahan ◽  
Maren Urner ◽  
Rosalyn Moran ◽  
Guillaume Flandin ◽  
Andre Marreiros ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Functional Mri ◽  
Brain Stimulation ◽  
Resting State ◽  
Effective Connectivity ◽  
The Impact ◽  
Deep Brain
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