scholarly journals Alteration of the regional cerebral glucose metabolism in healthy subjects by glucose loading

2016 ◽  
Vol 37 (8) ◽  
pp. 2823-2832 ◽  
Author(s):  
Kenji Ishibashi ◽  
Kei Wagatsuma ◽  
Kiichi Ishiwata ◽  
Kenji Ishii
Keyword(s):  
Glucose Metabolism ◽  
Healthy Subjects ◽  
Cerebral Glucose Metabolism ◽  
Glucose Loading ◽  
Regional Cerebral Glucose Metabolism

scholarly journals Regional Cerebral Glucose Metabolism in Turner Syndrome

1990 ◽  
Vol 17 (2) ◽  
pp. 140-144 ◽  
Author(s):  
C. Clark ◽  
H. Klonoff ◽  
M. Hayden
Keyword(s):  
Glucose Metabolism ◽  
Turner Syndrome ◽  
Parietal Cortex ◽  
Sex Chromosome ◽  
Occipital Cortex ◽  
Cerebral Glucose Metabolism ◽  
Brain Maturation ◽  
Visual Spatial ◽  
Primary Sensory Cortex ◽  
Regional Cerebral Glucose Metabolism

ABSTRACT:Regional cerebral glucose metabolism was examined in females with Turner syndrome, a sex chromosome abnormality. Previous studies have found a visual/spatial cognitive anomaly in these women but, to date, no abnormalities in brain structure or function have been associated with the condition. In the present study, decreases in regional metabolism were found in the occipital and parietal cortex. The involvement of the occipital cortex, although consistent with the observed cognitive anomalies, has not been suggested previously as an area dysfunction. Because the occipital cortex is a primary sensory cortex, the reduction of glucose metabolism in the parietal cortex may reflect a lack of innervation from the occipital cortex. Besides insight into the functional specialization of the brain, these findings are also consistent with previous reports on animals regarding the effects of estrogen in brain maturation.

Age at Onset and Regional Cerebral Glucose Metabolism in Alzheimer’s Disease

1998 ◽  
Vol 9 (2) ◽  
pp. 63-67 ◽  
Author(s):  
Fumihiko Yasuno ◽  
Toru Imamura ◽  
Nobutsugu Hirono ◽  
Kazunari Ishii ◽  
Masahiro Sasaki ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Glucose Metabolism ◽  
Age At Onset ◽  
Cerebral Glucose Metabolism ◽  
Regional Cerebral Glucose Metabolism

scholarly journals Cerebral Glucose and Dopa Metabolism in Movement Disorders

1987 ◽  
Vol 14 (S3) ◽  
pp. 448-451 ◽  
Author(s):  
W.R. Wayne Martin ◽  
Michael R. Hayden
Keyword(s):  
At Risk ◽  
Glucose Metabolism ◽  
Normal Subjects ◽  
Cerebral Glucose Metabolism ◽  
Nigrostriatal Pathway ◽  
Age Related ◽  
Positron Emission ◽  
Asymptomatic Individuals ◽  
Regional Cerebral Glucose Metabolism

ABSTRACT:The development of positron emission tomography (PET) has enabled us to perform in vivo measurements of certain aspects of regional cerebral function. Regional cerebral glucose metabolism may be readily quantified with [18F] fluoro-2-deoxyglucose (FDG) and presynaptic dopaminergic function may be studied with the labelled dopa analog 6-[18F] fluoro-L-dopa. We have applied a model to the analysis of 6-FD/PET data with which in vivo age-related changes in dopaminergic function may be demonstrated in normal subjects. With this technique, we have studied a series of asymptomatic MPTP-exposed subjects and have shown evidence of subclinical nigrostriatal pathway damage. Studies of regional cerebral glucose metabolism with FDG in early Huntington's disease have shown a characteristic impairment in caudate function which precedes the development of caudate atrophy. In addition, some asymptomatic individuals who are at risk for HD have caudate hypometabolism. We feel that, at the present time, PET provides information which is complementary to the clinical examination in establishing a diagnosis of HD. In the future these studies may also help in the investigation of at risk individuals

scholarly journals Reproducibility of Cerebral Glucose Metabolic Measurements in Resting Human Subjects

1988 ◽  
Vol 8 (4) ◽  
pp. 502-512 ◽  
Author(s):  
Elsa J. Bartlett ◽  
Jonathan D. Brodie ◽  
Alfred P. Wolf ◽  
David R. Christman ◽  
Eugene Laska ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Brain Metabolism ◽  
Human Subjects ◽  
Normal Subjects ◽  
Time Of Day ◽  
Cerebral Glucose Metabolism ◽  
Whole Brain ◽  
Positron Emission ◽  
Subcortical Regions ◽  
Regional Cerebral Glucose Metabolism

Positron emission tomography with 11C-2-deoxyglucose was used to determine the test-retest variability of regional cerebral glucose metabolism in 22 young normal right-handed men scanned twice in a 24-h period under baseline (resting) conditions. To assess the effects of scan order and time of day on variability, 12 subjects were scanned in the morning and afternoon of the same day (a.m.-p.m.) and 10 in the reverse order (p.m.-a.m.) with a night in between. The effect of anxiety on metabolism was also assessed. Seventy-three percent of the total subject group showed changes in whole brain metabolism from the first to the second measurement of 10% or less, with comparable changes in various cortical and subcortical regions. When a scaling factor was used to equate the whole brain metabolism in the two scans for each individual, the resulting average regional changes for each group were no mote than 1%. This suggests that the proportion of the whole brain metabolism utilized regionally is stable in a group of subjects over time. Both groups of subjects had lower morning than afternoon metabolism, but the differences were slight in the p.m.-a.m. group. One measure of anxiety (pulse at fun 1) was correlated with run 1 metabolism and with the percentage of change from run 1 to run 2. No significant run 2 correlations were observed. This is the first study to measure test-retest variability in cerebral glucose metabolism in a large sample of young normal subjects. It demonstrates that the deoxyglucose method yields low Intrasubject variability and high stability over a 24-h period.

Distinct patterns of regional cerebral glucose metabolism in Parkinson's disease with and without mild cognitive impairment

2009 ◽  
Vol 24 (6) ◽  
pp. 854-862 ◽  
Author(s):  
Yoshiyuki Hosokai ◽  
Yoshiyuki Nishio ◽  
Kazumi Hirayama ◽  
Atsushi Takeda ◽  
Toshiyuki Ishioka ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Glucose Metabolism ◽  
Cerebral Glucose Metabolism ◽  
Regional Cerebral Glucose Metabolism

scholarly journals Regional cerebral glucose metabolism in epilepsies with continuous spikes and waves during sleep

Neurology ◽  
2004 ◽  
Vol 63 (5) ◽  
pp. 853-857 ◽  
Author(s):  
X. De Tiege ◽  
S. Goldman ◽  
S. Laureys ◽  
D. Verheulpen ◽  
C. Chiron ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Cerebral Glucose Metabolism ◽  
Regional Cerebral Glucose Metabolism ◽  
Continuous Spikes And Waves
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