scholarly journals Sleep modulates cortical connectivity and excitability in humans: Direct evidence from neural activity induced by single-pulse electrical stimulation

2015 ◽  
Vol 36 (11) ◽  
pp. 4714-4729 ◽  
Author(s):  
Kiyohide Usami ◽  
Riki Matsumoto ◽  
Katsuya Kobayashi ◽  
Takefumi Hitomi ◽  
Akihiro Shimotake ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Neural Activity ◽  
Direct Evidence ◽  
Single Pulse ◽  
Cortical Connectivity

scholarly journals Single-pulse electrical stimulation methodology in freely moving rat

2021 ◽  
Vol 353 ◽  
pp. 109092
Author(s):  
Eloïse Gronlier ◽  
Estelle Vendramini ◽  
Julien Volle ◽  
Agata Wozniak-Kwasniewska ◽  
Noelia Antón Santos ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Single Pulse ◽  
Freely Moving

scholarly journals Effects of electrical stimulation on isolated rodent gastric smooth muscle cells evaluated via a joint computational simulation and experimental approach

2009 ◽  
Vol 297 (4) ◽  
pp. G672-G680 ◽  
Author(s):  
P. Du ◽  
S. Li ◽  
G. O'Grady ◽  
L. K. Cheng ◽  
A. J. Pullan ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Electrical Stimulation ◽  
Pulse Train ◽  
Pulse Width ◽  
Computational Simulation ◽  
Minimum Energy ◽  
Experimental Studies ◽  
Single Pulse ◽  
Plateau Phase ◽  
Wide Range

Gastric electrical stimulation (GES) involves the delivery of electrical impulses to the stomach for therapeutic purposes. New GES protocols are needed that are optimized for improved motility outcomes and energy efficiency. In this study, a biophysically based smooth muscle cell (SMC) model was modified on the basis of experimental data and employed in conjunction with experimental studies to define the effects of a large range of GES protocols on individual SMCs. For the validation studies, rat gastric SMCs were isolated and subjected to patch-clamp analysis during stimulation. Experimental results were in satisfactory agreement with simulation results. The results define the effects of a wide range of GES parameters (pulse width, amplitude, and pulse-train frequency) on isolated SMCs. The minimum pulse width required to invoke a supramechanical threshold response from SMCs (defined at −30 mV) was 65 ms (at 250-pA amplitude). The minimum amplitude required to invoke this threshold was 75 pA (at 1,000-ms pulse width). The amplitude of the invoked response beyond this threshold was proportional to the stimulation amplitude. A high-frequency train of stimuli (40 Hz; 10 ms, 150 pA) could invoke and maintain the SMC plateau phase while requiring 60% less power and accruing ∼30% less intracellular Ca2+ concentration during the plateau phase than a comparable single-pulse protocol could in a demonstrated example. Validated computational simulations are an effective strategy for efficiently identifying effective minimum-energy GES protocols, and pulse-train protocols may also help to reduce the power consumption of future GES devices.

scholarly journals Local and Distant responses to single pulse electrical stimulation reflect different forms of connectivity

2020 ◽  
Author(s):  
Britni Crocker ◽  
Lauren Ostrowski ◽  
Ziv M. Williams ◽  
Darin D. Dougherty ◽  
Emad N. Eskandar ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Resting State ◽  
Diffusion Tensor ◽  
Effective Connectivity ◽  
Clinical Care ◽  
Structural Connectivity ◽  
Intractable Epilepsy ◽  
Single Pulse ◽  
Intracranial Electrode ◽  
The Brain

AbstractBackgroundMeasuring connectivity in the human brain can involve innumerable approaches using both noninvasive (fMRI, EEG) and invasive (intracranial EEG or iEEG) recording modalities, including the use of external probing stimuli, such as direct electrical stimulation.Objective/HypothesisTo examine how different measures of connectivity correlate with one another, we compared ‘passive’ measures of connectivity during resting state conditions map to the more ‘active’ probing measures of connectivity with single pulse electrical stimulation (SPES).MethodsWe measured the network engagement and spread of the cortico-cortico evoked potential (CCEP) induced by SPES at 53 total sites across the brain, including cortical and subcortical regions, in patients with intractable epilepsy (N=11) who were undergoing intracranial recordings as a part of their clinical care for identifying seizure onset zones. We compared the CCEP network to functional, effective, and structural measures of connectivity during a resting state in each patient. Functional and effective connectivity measures included correlation or Granger causality measures applied to stereoEEG (sEEGs) recordings. Structural connectivity was derived from diffusion tensor imaging (DTI) acquired before intracranial electrode implant and monitoring (N=8).ResultsThe CCEP network was most similar to the resting state voltage correlation network in channels near to the stimulation location. In contrast, the distant CCEP network was most similar to the DTI network. Other connectivity measures were not as similar to the CCEP network.ConclusionsThese results demonstrate that different connectivity measures, including those derived from active stimulation-based probing, measure different, complementary aspects of regional interrelationships in the brain.

scholarly journals Single pulse electrical stimulation to probe functional and pathological connectivity in epilepsy

Seizure ◽  
2017 ◽  
Vol 44 ◽  
pp. 27-36 ◽  
Author(s):  
Riki Matsumoto ◽  
Takeharu Kunieda ◽  
Dileep Nair
Keyword(s):  
Electrical Stimulation ◽  
Single Pulse

Single pulse electrical stimulation for identification of structural abnormalities and prediction of seizure outcome after epilepsy surgery: a prospective study

2005 ◽  
Vol 4 (11) ◽  
pp. 718-726 ◽  
Author(s):  
Antonio Valentín ◽  
Gonzalo Alarcón ◽  
Mrinalini Honavar ◽  
Jorge J García Seoane ◽  
Richard P Selway ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Prospective Study ◽  
Epilepsy Surgery ◽  
Single Pulse ◽  
Seizure Outcome ◽  
Structural Abnormalities ◽  
A Prospective Study

scholarly journals Spatial shaping of neural activity using electrical stimulation

2013 ◽  
Vol 14 (S1) ◽  
Author(s):  
Hamish Meffin ◽  
Bahman Tahayori ◽  
Elma O'Sullivan Greeene ◽  
David B Grayden ◽  
Anthony N Burkitt
Keyword(s):  
Electrical Stimulation ◽  
Neural Activity

scholarly journals The Effects of Motor Cortical Stimulation on the Excitability of Spinal Motoneurons in Man

1975 ◽  
Vol 2 (3) ◽  
pp. 245-253 ◽  
Author(s):  
S.H. Milner-Brown ◽  
J.P. Girvin ◽  
W.F. Brown
Keyword(s):  
Stretch Reflex ◽  
Direct Evidence ◽  
Pyramidal Tract ◽  
Single Pulse ◽  
H Reflex ◽  
Cortical Stimulation ◽  
Spinal Motoneurons ◽  
Hand Muscles ◽  
Stimulus Current ◽  
Contralateral Hand

SUMMARY:The pyramidal tract and particularly the direct corticomotoneuronal components (DCM) have become increasingly important in the higher primates. Minimal single pulse precentral stimulation in man evokes EMG discharges from the contralateral hand muscles with a latency of 18-21 milliseconds. The excitability changes produced by such cortical stimulation on the upper limb H-reflex has been observed to include a short duration early facilitation probably corresponding to the DCM input and a later, longer lasting facilitation mediated by the same and probably other corticofugal projections. Potentiation of the H-reflex in the upper limbs by means of postcentral excitation required much higher single pulse stimulus intensities and the changes in excitability produced on the spinal motoneurons could have been explained by physical extension of the stimulus current to the precentral region. Isometric contraction potentiated the H-reflex produced by combinations of precentral cortical and peripheral nerve stimulation but no direct evidence was found to support a possible transcortical basis for the V2 stretch reflex.

Single pulse electrical stimulation of the hippocampus is sufficient to impair human episodic memory

Neuroscience ◽  
2010 ◽  
Vol 170 (2) ◽  
pp. 623-632 ◽  
Author(s):  
M.E. Lacruz ◽  
A. Valentín ◽  
J.J. García Seoane ◽  
R.G. Morris ◽  
R.P. Selway ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Episodic Memory ◽  
Single Pulse ◽  
Stimulation Of
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