scholarly journals Age-related changes in the topological organization of the white matter structural connectome across the human lifespan

2015 ◽  
Vol 36 (10) ◽  
pp. 3777-3792 ◽  
Author(s):  
Tengda Zhao ◽  
Miao Cao ◽  
Haijing Niu ◽  
Xi-Nian Zuo ◽  
Alan Evans ◽  
...  
Keyword(s):  
White Matter ◽  
Human Lifespan ◽  
Structural Connectome ◽  
Age Related ◽  
Topological Organization ◽  
Age Related Changes

Age-related changes in white matter integrity: A diffusion tensor imaging study

NeuroImage ◽  
2009 ◽  
Vol 47 ◽  
pp. S128
Author(s):  
H Lemaitre ◽  
S Marenco ◽  
M Emery ◽  
T Alam ◽  
M Geramita ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Imaging Study ◽  
White Matter Integrity ◽  
Age Related ◽  
Diffusion Tensor Imaging Study ◽  
Age Related Changes

scholarly journals Age-related changes in grey and white matter structure throughout adulthood

NeuroImage ◽  
2010 ◽  
Vol 51 (3) ◽  
pp. 943-951 ◽  
Author(s):  
Antonio Giorgio ◽  
Luca Santelli ◽  
Valentina Tomassini ◽  
Rose Bosnell ◽  
Steve Smith ◽  
...  
Keyword(s):  
White Matter ◽  
Age Related ◽  
Age Related Changes

540 Age Trends in Sleep Across the Lifespan: Findings from the Pittsburgh Lifespan Sleep Databank

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A213-A213
Author(s):  
Meredith Wallace ◽  
Nicholas Kissel ◽  
Martica Hall ◽  
Anne Germain ◽  
Karen Matthews ◽  
...  
Keyword(s):  
Sex Differences ◽  
Sleep Onset ◽  
Sleep Efficiency ◽  
Additive Models ◽  
Self Report ◽  
University Of Pittsburgh ◽  
Human Lifespan ◽  
Age Related ◽  
Age Trends ◽  
Age Related Changes

Abstract Introduction Sleep continuously changes over the human lifespan and it does so across multiple dimensions, including duration, timing, efficiency, and variability. Although studies focused on specific developmental periods have shown age-related changes in sleep, methodological differences make it difficult to synthesize information across studies to fully understand precisely when these sleep changes occur. Our goal was to use individual-level actigraphy and self-report sleep data from a single site to characterize age trends and sex differences in actigraphy and self-report sleep dimensions across the healthy human lifespan. To accomplish this goal, we developed the Pittsburgh Lifespan Sleep Databank (PLSD), a large aggregate databank of participants from sleep research studies conducted at the University of Pittsburgh. Methods In the present analysis, we included N=1,070 PLSD participants from 21 studies without a major psychiatric, sleep, or medical condition. We used Generalized Additive Models to examine flexible, potentially non-linear relationships between age and sleep dimensions (actigraphy and self-report duration, efficiency, and timing; actigraphy variability) from ages 10 to 87. We also examined whether these sleep characteristics differed by sex across the lifespan. Results The most dramatic age-related trends were observed in sleep timing. Actigraphy and self-report sleep onset time shifted later between ages 10–18 and then shifted earlier again during the 20s. Actigraphy and self-report wake-up time also shifted earlier during the mid-20s through late 30s. Self-report duration became shorter from approximately ages 10–20. Self-report sleep efficiency and actigraphy variability both decreased over the entire lifespan. Relative to males, females tended to have earlier self-report sleep onset, higher actigraphy sleep efficiency, and longer actigraphy duration. Conclusion By focusing on lifespan sleep rather than specific age segments of the samples, we can provide a unified assessment of age-related changes and sex differences from childhood through older adulthood. An understanding of age trends and sex differences in sleep in healthy individuals – and explicating the timing and nature of these difference – can be used to identify periods of sleep-related risk or resilience and guide intervention efforts. Support (if any) University of Pittsburgh Clinical and Translational Science Institute (UL1TR001857).

Side differences of the age-related changes in the white matter and the myelinated nerve fibers in the white matter of female rats

2011 ◽  
Vol 492 (2) ◽  
pp. 119-123 ◽  
Author(s):  
Xiao-yan Shi ◽  
Yuan-yu Zhao ◽  
Shu Yang ◽  
Chen Li ◽  
Lin Chen ◽  
...  
Keyword(s):  
White Matter ◽  
Nerve Fibers ◽  
Female Rats ◽  
Myelinated Nerve ◽  
Myelinated Nerve Fibers ◽  
Age Related ◽  
Age Related Changes
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