scholarly journals Longitudinal resting state fMRI analysis in healthy controls and premanifest Huntington's disease gene carriers: A three-year follow-up study

2014 ◽  
Vol 36 (1) ◽  
pp. 110-119 ◽  
Author(s):  
Omar F.F. Odish ◽  
Annette A. van den Berg-Huysmans ◽  
Simon J.A. van den Bogaard ◽  
Eve M. Dumas ◽  
Ellen P. Hart ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Resting State ◽  
Disease Gene ◽  
Resting State Fmri ◽  
Healthy Controls ◽  
Follow Up Study ◽  
Gene Carriers ◽  
Fmri Analysis

D14 Resting-state connectivity changes in huntington’s disease: a follow-up study

2016 ◽  
Vol 87 (Suppl 1) ◽  
pp. A38.3-A39
Author(s):  
Imis Dogan ◽  
Cornelius J Werner ◽  
Shahram Mirzazade ◽  
Johannes Schiefer ◽  
Jörg B Schulz ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Resting State ◽  
Follow Up Study ◽  
Resting State Connectivity

scholarly journals Loss of extra-striatal phosphodiesterase 10A expression in early premanifest Huntington's disease gene carriers

2016 ◽  
Vol 368 ◽  
pp. 243-248 ◽  
Author(s):  
Heather Wilson ◽  
Flavia Niccolini ◽  
Salman Haider ◽  
Tiago Reis Marques ◽  
Gennaro Pagano ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Disease Gene ◽  
Gene Carriers ◽  
Phosphodiesterase 10A

Psychopathology in Verified Huntington’s Disease Gene Carriers

2007 ◽  
Vol 19 (4) ◽  
pp. 441-448 ◽  
Author(s):  
E. van Duijn ◽  
E.M. Kingma ◽  
R.C. van der Mast
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Disease Gene ◽  
Gene Carriers

Disease stage and plasma levels of cytokines in Huntington's disease: A 2-year follow-up study

2017 ◽  
Vol 32 (7) ◽  
pp. 1103-1104 ◽  
Author(s):  
J.A. Bouwens ◽  
E. van Duijn ◽  
C.M. Cobbaert ◽  
R.A.C. Roos ◽  
R.C. van der Mast ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Plasma Levels ◽  
Disease Stage ◽  
Follow Up Study

scholarly journals The unified huntington's disease rating scale for advanced patients: Validation and follow-up study

2013 ◽  
Vol 28 (14) ◽  
pp. 1995-2001 ◽  
Author(s):  
Katia Youssov ◽  
Guillaume Dolbeau ◽  
Patrick Maison ◽  
Marie-Françoise Boissé ◽  
Laurent Cleret de Langavant ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Rating Scale ◽  
Follow Up Study ◽  
Disease Rating

Psychiatric Disorders in Huntington's Disease: A 2-Year Follow-up Study

2012 ◽  
Vol 53 (3) ◽  
pp. 220-229 ◽  
Author(s):  
W. Reedeker ◽  
R.C. van der Mast ◽  
E.J. Giltay ◽  
T.A.D. Kooistra ◽  
R.A.C. Roos ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Psychiatric Disorders ◽  
Huntington’S Disease ◽  
Follow Up Study

Pilot Validation of Ambulatory Activity Monitors for Sleep Measurement in Huntington’s Disease Gene Carriers

2017 ◽  
Vol 6 (3) ◽  
pp. 249-253 ◽  
Author(s):  
Svetlana Maskevich ◽  
Ria Jumabhoy ◽  
Pierre D.M. Dao ◽  
Julie C. Stout ◽  
Sean P.A. Drummond
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Disease Gene ◽  
Ambulatory Activity ◽  
Activity Monitors ◽  
Gene Carriers ◽  
Sleep Measurement

Abnormal resting-state connectivity of motor and cognitive networks in early manifest Huntington's disease

2014 ◽  
Vol 44 (15) ◽  
pp. 3341-3356 ◽  
Author(s):  
R. C. Wolf ◽  
F. Sambataro ◽  
N. Vasic ◽  
M. S. Depping ◽  
P. A. Thomann ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Motor Function ◽  
Neural Activity ◽  
Resting State ◽  
Brain Atrophy ◽  
Clinical Symptoms ◽  
Resting State Fmri ◽  
Cognitive Networks ◽  
The Impact

Background.Functional magnetic resonance imaging (fMRI) of multiple neural networks during the brain's ‘resting state’ could facilitate biomarker development in patients with Huntington's disease (HD) and may provide new insights into the relationship between neural dysfunction and clinical symptoms. To date, however, very few studies have examined the functional integrity of multiple resting state networks (RSNs) in manifest HD, and even less is known about whether concomitant brain atrophy affects neural activity in patients.Method.Using MRI, we investigated brain structure and RSN function in patients with early HD (n = 20) and healthy controls (n = 20). For resting-state fMRI data a group-independent component analysis identified spatiotemporally distinct patterns of motor and prefrontal RSNs of interest. We used voxel-based morphometry to assess regional brain atrophy, and ‘biological parametric mapping’ analyses to investigate the impact of atrophy on neural activity.Results.Compared with controls, patients showed connectivity changes within distinct neural systems including lateral prefrontal, supplementary motor, thalamic, cingulate, temporal and parietal regions. In patients, supplementary motor area and cingulate cortex connectivity indices were associated with measures of motor function, whereas lateral prefrontal connectivity was associated with cognition.Conclusions.This study provides evidence for aberrant connectivity of RSNs associated with motor function and cognition in early manifest HD when controlling for brain atrophy. This suggests clinically relevant changes of RSN activity in the presence of HD-associated cortical and subcortical structural abnormalities.

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