scholarly journals The default mode network is disrupted in parkinson's disease with visual hallucinations

2014 ◽  
Vol 35 (11) ◽  
pp. 5658-5666 ◽  
Author(s):  
Nailin Yao ◽  
Richard Shek‐Kwan Chang ◽  
Charlton Cheung ◽  
Shirley Pang ◽  
Kui Kai Lau ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Default Mode Network ◽  
Visual Hallucinations ◽  
Default Mode

Default mode network links to visual hallucinations: A comparison between Parkinson's disease and multiple system atrophy

2015 ◽  
Vol 30 (9) ◽  
pp. 1237-1247 ◽  
Author(s):  
Raffaella Franciotti ◽  
Stefano Delli Pizzi ◽  
Bernardo Perfetti ◽  
Armando Tartaro ◽  
Laura Bonanni ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Multiple System Atrophy ◽  
Default Mode Network ◽  
Visual Hallucinations ◽  
Default Mode ◽  
Network Links

Dopaminergic modulation of the default mode network in Parkinson's disease

2010 ◽  
Vol 20 (11) ◽  
pp. 784-792 ◽  
Author(s):  
Pauline Delaveau ◽  
Pilar Salgado-Pineda ◽  
Philippe Fossati ◽  
Tatiana Witjas ◽  
Jean-Philippe Azulay ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Default Mode Network ◽  
Default Mode ◽  
Dopaminergic Modulation

Primary disruption of the default mode network subsystems in drug-naïve Parkinson’s disease with mild cognitive impairments

2020 ◽  
Vol 62 (6) ◽  
pp. 685-692 ◽  
Author(s):  
Yanbing Hou ◽  
Xiaoqin Yuan ◽  
Qianqian Wei ◽  
Ruwei Ou ◽  
Jing Yang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Default Mode Network ◽  
Cognitive Impairments ◽  
Default Mode ◽  
Drug Naïve

Levodopa imparts a normalizing effect on default-mode network connectivity in non-demented Parkinson’s disease

2019 ◽  
Vol 705 ◽  
pp. 159-166 ◽  
Author(s):  
Jianguo Zhong ◽  
Xiaojun Guan ◽  
Xia Zhong ◽  
Fang Cao ◽  
Quanquan Gu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Default Mode Network ◽  
Network Connectivity ◽  
Default Mode

scholarly journals Salience and Default Mode Network Coupling Predicts Cognition in Aging and Parkinson’s Disease

2016 ◽  
Vol 22 (2) ◽  
pp. 205-215 ◽  
Author(s):  
Deepti Putcha ◽  
Robert S. Ross ◽  
Alice Cronin-Golomb ◽  
Amy C. Janes ◽  
Chantal E. Stern
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Default Mode Network ◽  
Verbal Memory ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Central Executive ◽  
Functional Coupling ◽  
Salience Network ◽  
Default Mode ◽  
Imaging Results

AbstractObjectives:Cognitive impairment is common in Parkinson’s disease (PD). Three neurocognitive networks support efficient cognition: the salience network, the default mode network, and the central executive network. The salience network is thought to switch between activating and deactivating the default mode and central executive networks. Anti-correlated interactions between the salience and default mode networks in particular are necessary for efficient cognition. Our previous work demonstrated altered functional coupling between the neurocognitive networks in non-demented individuals with PD compared to age-matched control participants. Here, we aim to identify associations between cognition and functional coupling between these neurocognitive networks in the same group of participants.Methods:We investigated the extent to which intrinsic functional coupling among these neurocognitive networks is related to cognitive performance across three neuropsychological domains: executive functioning, psychomotor speed, and verbal memory. Twenty-four non-demented individuals with mild to moderate PD and 20 control participants were scanned at rest and evaluated on three neuropsychological domains.Results:PD participants were impaired on tests from all three domains compared to control participants. Our imaging results demonstrated that successful cognition across healthy aging and Parkinson’s disease participants was related to anti-correlated coupling between the salience and default mode networks. Individuals with poorer performance scores across groups demonstrated more positive salience network/default-mode network coupling.Conclusions:Successful cognition relies on healthy coupling between the salience and default mode networks, which may become dysfunctional in PD. These results can help inform non-pharmacological interventions (repetitive transcranial magnetic stimulation) targeting these specific networks before they become vulnerable in early stages of Parkinson’s disease. (JINS, 2016,22, 205–215)

Default Mode Network: Potential Biomarker for Mild Cognitive Impairment in Parkinson’s Disease

2015 ◽  
Vol 96 (10) ◽  
pp. e91-e92 ◽  
Author(s):  
Sandra Kletzel ◽  
Brett Harton ◽  
Alicia Kopicki ◽  
Amy A. Herrold ◽  
Tanya Simuni ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Default Mode Network ◽  
Default Mode ◽  
Potential Biomarker
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