scholarly journals A functional MRI study of the relationship between naming treatment outcomes and resting state functional connectivity in post-stroke aphasia

2014 ◽  
Vol 35 (8) ◽  
pp. 3919-3931 ◽  
Author(s):  
Sophia van Hees ◽  
Katie McMahon ◽  
Anthony Angwin ◽  
Greig de Zubicaray ◽  
Stephen Read ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Treatment Outcomes ◽  
Functional Mri ◽  
Resting State ◽  
Resting State Functional Connectivity ◽  
Post Stroke ◽  
Mri Study ◽  
The Relationship

Functional connectivity of the ventral tegmental area and avolition in subjects with schizophrenia: a resting state functional MRI study

2018 ◽  
Vol 28 (5) ◽  
pp. 589-602 ◽  
Author(s):  
Giulia Maria Giordano ◽  
Mario Stanziano ◽  
Michele Papa ◽  
Armida Mucci ◽  
Anna Prinster ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Ventral Tegmental Area ◽  
Functional Mri ◽  
Resting State ◽  
Ventral Tegmental ◽  
Mri Study

scholarly journals Resting-state functional connectivity, cortical GABA and neuroactive steroids in peripartum and peripartum depressed women: a functional magnetic imaging and resonance study

2018 ◽  
Author(s):  
Kristina M. Deligiannidis ◽  
Christina L. Fales ◽  
Aimee R. Kroll-Desrosiers ◽  
Scott A. Shaffer ◽  
Vanessa Villamarin ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Neuroactive Steroids ◽  
Anterior Cingulate ◽  
Resonance Spectroscopy ◽  
Resting State Functional Connectivity ◽  
Magnetic Imaging ◽  
Temporal Pole ◽  
The Right ◽  
The Relationship

ABSTRACTPostpartum depression (PPD) is associated with abnormalities in resting-state functional connectivity (RSFC) but the underlying neurochemistry is unclear. We hypothesized that peripartum GABAergic neuroactive steroids (NAS) are related to cortical GABA concentrations and RSFC in PPD as compared to healthy comparison women (HCW). To test this, we measured RSFC with fMRI and GABA+/Creatine (Cr) concentrations with proton magnetic resonance spectroscopy (1H MRS) in the pregenual anterior cingulate (pgACC) and occipital cortices (OCC) and quantified peripartum plasma NAS. We examined between-group differences in RSFC and the relationship between cortical GABA+/Cr concentrations with RSFC. We investigated the relationship between NAS, RSFC and cortical GABA+/Cr concentrations. Within the default mode network (DMN) an area of the dorsomedial prefrontal cortex (DMPFC) had greater connectivity with the rest of the DMN in PPD (peak voxel: MNI coordinates (2, 58, 32), p=0.002) and was correlated to depression scores (peak HAM-D17 voxel: MNI coordinates (0, 60, 34), p=0.008). pgACC GABA+/Cr correlated positively with DMPFC RSFC in a region spanning the right anterior/posterior insula and right temporal pole (r=+0.661, p=0.000). OCC GABA+/Cr correlated positively with regions spanning both amygdalae (right amygdala: r=+0.522, p=0.000; left amygdala: r=+0.651, p=0.000) as well as superior parietal areas. Plasma allopregnanolone was higher in PPD (p=0.03) and positively correlated with intra DMPFC connectivity (r=+0.548, p=0.000) but not GABA+/Cr. These results provide initial evidence that PPD is associated with altered DMN connectivity; cortical GABA+/Cr concentrations are associated with postpartum RSFC and allopregnanolone is associated with postpartum intra-DMPFC connectivity.

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