scholarly journals Expertise modulates local regional homogeneity of spontaneous brain activity in the resting brain: An fMRI study using the model of skilled acupuncturists

2013 ◽  
Vol 35 (3) ◽  
pp. 1074-1084 ◽  
Author(s):  
Minghao Dong ◽  
Wei Qin ◽  
Ling Zhao ◽  
Xuejuan Yang ◽  
Kai Yuan ◽  
...  
Keyword(s):  
Brain Activity ◽  
Regional Homogeneity ◽  
Spontaneous Brain Activity ◽  
Fmri Study

Distinguishing hypochondriasis and schizophrenia using regional homogeneity: a resting-state fMRI study and support vector machine analysis

2021 ◽  
pp. 1-29
Author(s):  
Kangyu Jin ◽  
Zhe Shen ◽  
Guoxun Feng ◽  
Zhiyong Zhao ◽  
Jing Lu ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Resting State ◽  
Parietal Lobe ◽  
Brain Activity ◽  
Resting State Fmri ◽  
Brain Regions ◽  
Regional Homogeneity ◽  
Middle Temporal Gyrus ◽  
Support Vector ◽  
Fmri Study

Abstract Objective: A few former studies suggested there are partial overlaps in abnormal brain structure and cognitive function between Hypochondriasis (HS) and schizophrenia (SZ). But their differences in brain activity and cognitive function were unclear. Methods: 21 HS patients, 23 SZ patients, and 24 healthy controls (HC) underwent Resting-state functional magnetic resonance imaging (rs-fMRI) with the regional homogeneity analysis (ReHo), subsequently exploring the relationship between ReHo value and cognitive functions. The support vector machines (SVM) were used on effectiveness evaluation of ReHo for differentiating HS from SZ. Results: Compared with HC, HS showed significantly increased ReHo values in right middle temporal gyrus (MTG), left inferior parietal lobe (IPL) and right fusiform gyrus (FG), while SZ showed increased ReHo in left insula, decreased ReHo values in right paracentral lobule. Additionally, HS showed significantly higher ReHo values in FG, MTG and left paracentral lobule but lower in insula than SZ. The higher ReHo values in insula were associated with worse performance in MCCB in HS group. SVM analysis showed a combination of the ReHo values in insula and FG was able to satisfactorily distinguish the HS and SZ patients. Conclusion: our results suggested the altered default mode network (DMN), of which abnormal spontaneous neural activity occurs in multiple brain regions, might play a key role in the pathogenesis of HS, and the resting-state alterations of insula closely related to cognitive dysfunction in HS. Furthermore, the combination of the ReHo in FG and insula was a relatively ideal indicator to distinguish HS from SZ.

scholarly journals Using Regional Homogeneity to Reveal Altered Spontaneous Activity in Patients with Mild Cognitive Impairment

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Yumei Wang ◽  
Xiaochuan Zhao ◽  
Shunjiang Xu ◽  
Lulu Yu ◽  
Lan Wang ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Spontaneous Activity ◽  
Healthy Aging ◽  
Early Stage ◽  
Brain Activity ◽  
Regional Homogeneity ◽  
Whole Brain ◽  
Spontaneous Brain Activity ◽  
Regional Brain Activity

Most patients with mild cognitive impairment (MCI) are thought to be in an early stage of Alzheimer’s disease (AD). Resting-state functional magnetic resonance imaging reflects spontaneous brain activity and/or the endogenous/background neurophysiological process of the human brain. Regional homogeneity (ReHo) rapidly maps regional brain activity across the whole brain. In the present study, we used the ReHo index to explore whole brain spontaneous activity pattern in MCI. Our results showed that MCI subjects displayed an increased ReHo index in the paracentral lobe, precuneus, and postcentral and a decreased ReHo index in the medial temporal gyrus and hippocampus. Impairments in the medial temporal gyrus and hippocampus may serve as important markers distinguishing MCI from healthy aging. Moreover, the increased ReHo index observed in the postcentral and paracentral lobes might indicate compensation for the cognitive function losses in individuals with MCI.

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