scholarly journals Right and left perisylvian cortex and left inferior frontal cortex mediate sentence-level rhyme detection in spoken language as revealed by sparse fMRI

2012 ◽  
Vol 34 (12) ◽  
pp. 3182-3192 ◽  
Author(s):  
Martina A. Hurschler ◽  
Franziskus Liem ◽  
Lutz Jäncke ◽  
Martin Meyer
Keyword(s):  
Frontal Cortex ◽  
Spoken Language ◽  
Inferior Frontal Cortex ◽  
Sentence Level ◽  
Rhyme Detection

scholarly journals Modulating the left inferior frontal cortex by task domain, cognitive challenge and tDCS

2021 ◽  
Author(s):  
Davide Nardo ◽  
Katerina Pappa ◽  
John Duncan ◽  
Peter Zeidman ◽  
Martina F. Callaghan ◽  
...  
Keyword(s):  
Frontal Cortex ◽  
Language Processing ◽  
Functional Neuroimaging ◽  
Brain Activity ◽  
Spoken Language ◽  
Spoken Language Processing ◽  
Domain Specific ◽  
Inferior Frontal Cortex ◽  
Domain Generality ◽  
Cognitive Challenge

ABSTRACTThe left inferior frontal cortex (LIFC) is a key region for spoken language processing, but its neurocognitive architecture remains controversial. Here we assess the domain-generality vs. domain-specificity of the LIFC from behavioural, functional neuroimaging and neuromodulation data. Using concurrent fMRI and transcranial direct current stimulation (tDCS) delivered to the LIFC, we investigated how brain activity and behavioural performance are modulated by task domain (naming vs. non-naming), cognitive challenge (low vs. high), and tDCS (anodal vs. sham). The data revealed: (1) co-existence of neural signatures both common and distinct across tasks within the LIFC; (2) domain-preferential effects of task (naming); (3) significant tDCS modulations of activity in a LIFC sub-region selectively during high-challenge naming. The presence of both domain-specific and domain-general signals, and the existence of a gradient of activation where naming relied more on sub-regions within the LIFC, may help reconcile both perspectives on spoken language processing.

An active role of inferior frontal cortex in conscious experience

2021 ◽  
Author(s):  
Veith Weilnhammer ◽  
Merve Fritsch ◽  
Meera Chikermane ◽  
Anna-Lena Eckert ◽  
Katharina Kanthak ◽  
...  
Keyword(s):  
Frontal Cortex ◽  
Conscious Experience ◽  
Active Role ◽  
Inferior Frontal Cortex

scholarly journals Decreased event-related theta power and phase-synchrony in young binge drinkers during target detection: An anatomically-constrained MEG approach

2018 ◽  
Vol 33 (3) ◽  
pp. 335-346 ◽  
Author(s):  
A Correas ◽  
E López-Caneda ◽  
L Beaton ◽  
S Rodríguez Holguín ◽  
LM García-Moreno ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Frontal Cortex ◽  
Binge Drinking ◽  
Target Detection ◽  
Attentional Control ◽  
Theta Power ◽  
Inferior Frontal Cortex ◽  
Binge Drinkers ◽  
The Right ◽  
Integrative Processing

Background: The prevalence of binge drinking has risen in recent years. It is associated with a range of neurocognitive deficits among adolescents and young emerging adults who are especially vulnerable to alcohol use. Attention is an essential dimension of executive functioning and attentional disturbances may be associated with hazardous drinking. The aim of the study was to examine the oscillatory neural dynamics of attentional control during visual target detection in emerging young adults as a function of binge drinking. Method: In total, 51 first-year university students (18 ± 0.6 years) were assigned to light drinking ( n = 26), and binge drinking ( n = 25) groups based on their alcohol consumption patterns. A high-density magnetoencephalography signal was combined with structural magnetic resonance imaging in an anatomically constrained magnetoencephalography model to estimate event-related source power in a theta (4–7 Hz) frequency band. Phase-locked co-oscillations were further estimated between the principally activated regions during task performance. Results: Overall, the greatest event-related theta power was elicited by targets in the right inferior frontal cortex and it correlated with performance accuracy and selective attention scores. Binge drinkers exhibited lower theta power and dysregulated oscillatory synchrony to targets in the right inferior frontal cortex, which correlated with higher levels of alcohol consumption. Conclusions: These results confirm that a highly interactive network in the right inferior frontal cortex subserves attentional control, revealing the importance of theta oscillations and neural synchrony for attentional capture and contextual maintenance. Attenuation of theta power and synchronous interactions in binge drinkers may indicate early stages of suboptimal integrative processing in young, highly functioning binge drinkers.

scholarly journals An exploration of face selectivity in human inferior frontal cortex

2010 ◽  
Vol 6 (6) ◽  
pp. 663-663 ◽  
Author(s):  
A. W.-Y. Chan ◽  
M. V. Peelen ◽  
P. E. Downing
Keyword(s):  
Frontal Cortex ◽  
Inferior Frontal Cortex ◽  
Face Selectivity

scholarly journals Task-Dependent Modulation of Regions in the Left Inferior Frontal Cortex during Semantic Processing

2001 ◽  
Vol 13 (6) ◽  
pp. 829-843 ◽  
Author(s):  
A. L. Roskies ◽  
J. A. Fiez ◽  
D. A. Balota ◽  
M. E. Raichle ◽  
S. E. Petersen
Keyword(s):  
Frontal Cortex ◽  
Language Processing ◽  
Semantic Processing ◽  
Semantic Analysis ◽  
Lexical Processing ◽  
Temporal Cortex ◽  
Dependent Manner ◽  
Inferior Frontal Cortex ◽  
Semantic Judgment ◽  
The Right

To distinguish areas involved in the processing of word meaning (semantics) from other regions involved in lexical processing more generally, subjects were scanned with positron emission tomography (PET) while performing lexical tasks, three of which required varying degrees of semantic analysis and one that required phonological analysis. Three closely apposed regions in the left inferior frontal cortex and one in the right cerebellum were significantly active above baseline in the semantic tasks, but not in the nonsemantic task. The activity in two of the frontal regions was modulated by the difficulty of the semantic judgment. Other regions, including some in the left temporal cortex and the cerebellum, were active across all four language tasks. Thus, in addition to a number of regions known to be active during language processing, regions in the left inferior frontal cortex were specifically recruited during semantic processing in a task-dependent manner. A region in the right cerebellum may be functionally related to those in the left inferior frontal cortex. Discussion focuses on the implications of these results for current views regarding neural substrates of semantic processing.

The role of inferior frontal cortex in belief-bias reasoning: An rTMS study

2010 ◽  
Vol 48 (7) ◽  
pp. 2005-2008 ◽  
Author(s):  
Takeo Tsujii ◽  
Sayako Masuda ◽  
Takekazu Akiyama ◽  
Shigeru Watanabe
Keyword(s):  
Frontal Cortex ◽  
Belief Bias ◽  
Inferior Frontal Cortex

scholarly journals The effects of acute fluoxetine administration on temporal discounting in youth with ADHD

2015 ◽  
Vol 46 (6) ◽  
pp. 1197-1209 ◽  
Author(s):  
C. O. Carlisi ◽  
K. Chantiluke ◽  
L. Norman ◽  
A. Christakou ◽  
N. Barrett ◽  
...  
Keyword(s):  
Frontal Cortex ◽  
Repeated Measures ◽  
Premotor Cortex ◽  
Temporal Discounting ◽  
Drug Condition ◽  
Default Mode ◽  
Hyperactivity Disorder ◽  
Serotonin Agonist ◽  
Inferior Frontal Cortex ◽  
Randomized Design

BackgroundSerotonin is under-researched in attention deficit hyperactivity disorder (ADHD), despite accumulating evidence for its involvement in impulsiveness and the disorder. Serotonin further modulates temporal discounting (TD), which is typically abnormal in ADHD relative to healthy subjects, underpinned by reduced fronto-striato-limbic activation. This study tested whether a single acute dose of the selective serotonin reuptake inhibitor (SSRI) fluoxetine up-regulates and normalizes reduced fronto-striato-limbic neurofunctional activation in ADHD during TD.MethodTwelve boys with ADHD were scanned twice in a placebo-controlled randomized design under either fluoxetine (between 8 and 15 mg, titrated to weight) or placebo while performing an individually adjusted functional magnetic resonance imaging TD task. Twenty healthy controls were scanned once. Brain activation was compared in patients under either drug condition and compared to controls to test for normalization effects.ResultsRepeated-measures whole-brain analysis in patients revealed significant up-regulation with fluoxetine in a large cluster comprising right inferior frontal cortex, insula, premotor cortex and basal ganglia, which further correlated trend-wise with TD performance, which was impaired relative to controls under placebo, but normalized under fluoxetine. Fluoxetine further down-regulated default mode areas of posterior cingulate and precuneus. Comparisons between controls and patients under either drug condition revealed normalization with fluoxetine in right premotor-insular-parietal activation, which was reduced in patients under placebo.ConclusionsThe findings show that a serotonin agonist up-regulates activation in typical ADHD dysfunctional areas in right inferior frontal cortex, insula and striatum as well as down-regulating default mode network regions in the context of impulsivity and TD.

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