scholarly journals Preferential networks of the mediodorsal nucleus and centromedian-parafascicular complex of the thalamus-A DTI tractography study

2011 ◽  
Vol 33 (11) ◽  
pp. 2627-2637 ◽  
Author(s):  
Ulf Eckert ◽  
Coraline D. Metzger ◽  
Julia E. Buchmann ◽  
Jörn Kaufmann ◽  
Annemarie Osoba ◽  
...  
Keyword(s):  
Mediodorsal Nucleus ◽  
Dti Tractography ◽  
Parafascicular Complex

scholarly journals Status Epilepticus Causes Necrotic Damage in the Mediodorsal Nucleus of the Thalamus in Immature Rats

2001 ◽  
Vol 21 (10) ◽  
pp. 3593-3599 ◽  
Author(s):  
Hana Kubová ◽  
Rastislav Druga ◽  
Katarzyna Lukasiuk ◽  
Lucie Suchomelová ◽  
Renata Haugvicová ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Mediodorsal Nucleus ◽  
Immature Rats

scholarly journals A preliminary study of the clinical application of optic pathway diffusion tensor tractography in suprasellar tumor surgery: preoperative, intraoperative, and postoperative assessment

2016 ◽  
Vol 125 (3) ◽  
pp. 759-765 ◽  
Author(s):  
Mohamadreza Hajiabadi ◽  
Madjid Samii ◽  
Rudolf Fahlbusch
Keyword(s):  
Visual Acuity ◽  
Visual Field ◽  
Diffusion Tensor ◽  
Tumor Resection ◽  
Visual Pathway ◽  
Optic Chiasm ◽  
Control Group ◽  
Optic Pathway ◽  
Dti Tractography ◽  
Mass Lesions

OBJECT Visual impairments are the most common objective manifestations of suprasellar lesions. Diffusion tensor imaging (DTI) is a noninvasive MRI modality that depicts the subcortical white matter tracts in vivo. In this study the authors tested the value of visual pathway tractography in comparison with visual field and visual acuity analyses. METHODS This prospective study consisted of 25 patients with progressive visual impairment due to suprasellar mass lesions and 6 control patients with normal vision without such lesions. Visual acuity, visual field, and the optic fundus were examined preoperatively and repeated 1 week and 3 months after surgery. Visual pathway DTI tractography was performed preoperatively, intraoperatively immediately after tumor resection, and 1 week and 3 months after surgery. RESULTS In the control group, pre- and postoperative visual status were normal and visual pathway tractography revealed fibers crossing the optic chiasm without any alteration. In patients with suprasellar lesions, vision improved in 24 of 25. The mean distance between optic tracts in tractography decreased after tumor resection and detectable fibers crossing the optic chiasm increased from 12% preoperatively to 72% postoperatively 3 months after tumor resection, and undetectable fibers crossing the optic chiasm decreased from 88% preoperatively to 27% postoperatively 3 months after tumor resection. Visual improvement after tumor removal 1 week and 3 months after surgery was significantly correlated with the distance between optic tracts in intraoperative tractography (p < 0.01). CONCLUSIONS Visual pathway DTI tractography appears to be a promising adjunct to the standard clinical and paraclinical visual examinations in patients with suprasellar mass lesions. The intraoperative findings, in particular the distance between optic tract fibers, can predict visual outcome after tumor resection. Furthermore, postoperative application of this technique may be useful in following anterior optic pathway recovery.

Functional outcomes after resection of middle frontal gyrus diffuse gliomas

2021 ◽  
pp. 1-8
Author(s):  
Ramin A. Morshed ◽  
Anthony T. Lee ◽  
Elaina J. Wang ◽  
Jacob S. Young ◽  
Soonmee Cha ◽  
...  
Keyword(s):  
Functional Outcomes ◽  
Middle Frontal Gyrus ◽  
Diffuse Glioma ◽  
Minimal Risk ◽  
Who Grade ◽  
Intraoperative Mapping ◽  
Diffuse Gliomas ◽  
The Mean ◽  
Dti Tractography ◽  
Subcortical Mapping

OBJECTIVE The clinical outcomes for patients undergoing resection of diffuse glioma within the middle frontal gyrus (MFG) are understudied. Anatomically, the MFG is richly interconnected to known language areas, and nearby subcortical fibers are at risk during resection. The goal of this study was to determine the functional outcomes and intraoperative mapping results related to resection of MFG gliomas. Additionally, the study aimed to evaluate if subcortical tract disruption on imaging correlated with functional outcomes. METHODS The authors performed a retrospective review of 39 patients with WHO grade II–IV diffuse gliomas restricted to only the MFG and underlying subcortical region that were treated with resection and had no prior treatment. Intraoperative mapping results and postoperative neurological deficits by discharge and 90 days were assessed. Diffusion tensor imaging (DTI) tractography was used to assess subcortical tract integrity on pre- and postoperative imaging. RESULTS The mean age of the cohort was 37.9 years at surgery, and the median follow-up was 5.1 years. The mean extent of resection was 98.9% for the cohort. Of the 39 tumors, 24 were left sided (61.5%). Thirty-six patients (92.3%) underwent intraoperative mapping, with 59% of patients undergoing an awake craniotomy. No patients had positive cortical mapping sites overlying the tumor, and 12 patients (33.3%) had positive subcortical stimulation sites. By discharge, 8 patients had language dysfunction, and 5 patients had mild weakness. By 90 days, 2 patients (5.1%) had persistent mild hand weakness only. There were no persistent language deficits by 90 days. On univariate analysis, preoperative tumor size (p = 0.0001), positive subcortical mapping (p = 0.03), preoperative tumor invasion of neighboring subcortical tracts on DTI tractography (p = 0.0003), and resection cavity interruption of subcortical tracts on DTI tractography (p < 0.0001) were associated with an increased risk of having a postoperative deficit by discharge. There were no instances of complete subcortical tract transections in the cohort. CONCLUSIONS MFG diffuse gliomas may undergo extensive resection with minimal risk for long-term morbidity. Partial subcortical tract interruption may lead to transient but not permanent deficits. Subcortical mapping is essential to reduce permanent morbidity during resection of MFG tumors by avoiding complete transection of critical subcortical tracts.

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