scholarly journals Reduced fronto-callosal fiber integrity in unmedicated OCD patients: A diffusion tractography study

2011 ◽  
Vol 33 (10) ◽  
pp. 2441-2452 ◽  
Author(s):  
Jungsu S. Oh ◽  
Joon Hwan Jang ◽  
Wi Hoon Jung ◽  
Do-Hyung Kang ◽  
Jung-Seok Choi ◽  
...  
Keyword(s):  
Diffusion Tractography ◽  
Callosal Fiber

scholarly journals Q -ball imaging of macaque white matter architecture

2005 ◽  
Vol 360 (1457) ◽  
pp. 869-879 ◽  
Author(s):  
David S Tuch ◽  
Jonathan J Wisco ◽  
Mark H Khachaturian ◽  
Leeland B Ekstrom ◽  
Rolf Kötter ◽  
...  
Keyword(s):  
White Matter ◽  
Magnetic Resonance ◽  
Diffusion Imaging ◽  
Large Body ◽  
Macaque Monkey ◽  
High Angular Resolution ◽  
Imaging Method ◽  
Diffusion Tractography ◽  
Axonal Projections ◽  
Histological Validation

Diffusion-weighted magnetic resonance imaging holds substantial promise as a technique for non-invasive imaging of white matter (WM) axonal projections. For diffusion imaging to be capable of providing new insight into the connectional neuroanatomy of the human brain, it will be necessary to histologically validate the technique against established tracer methods such as horseradish peroxidase and biocytin histochemistry. The macaque monkey provides an ideal model for histological validation of the diffusion imaging method due to the phylogenetic proximity between humans and macaques, the gyrencephalic structure of the macaque cortex, the large body of knowledge on the neuroanatomic connectivity of the macaque brain and the ability to use comparable magnetic resonance acquisition protocols in both species. Recently, it has been shown that high angular resolution diffusion imaging (HARDI) can resolve multiple axon orientations within an individual imaging voxel in human WM. This capability promises to boost the accuracy of tract reconstructions from diffusion imaging. If the macaque is to serve as a model for histological validation of the diffusion tractography method, it will be necessary to show that HARDI can also resolve intravoxel architecture in macaque WM. The present study therefore sought to test whether the technique can resolve intravoxel structure in macaque WM. Using a HARDI method called q -ball imaging (QBI) it was possible to resolve composite intravoxel architecture in a number of anatomic regions. QBI resolved intravoxel structure in, for example, the dorsolateral convexity, the pontine decussation, the pulvinar and temporal subcortical WM. The paper concludes by reviewing remaining challenges for the diffusion tractography project.

MR Diffusion Tractography

Diffusion MRI ◽  
2009 ◽  
pp. 333-351 ◽  
Author(s):  
Timothy E.J. Behrens ◽  
Saad Jbabdi
Keyword(s):  
Diffusion Tractography ◽  
Mr Diffusion

scholarly journals Author Correction: The challenge of mapping the human connectome based on diffusion tractography

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Klaus H. Maier-Hein ◽  
Peter F. Neher ◽  
Jean-Christophe Houde ◽  
Marc-Alexandre Côté ◽  
Eleftherios Garyfallidis ◽  
...  
Keyword(s):  
Diffusion Tractography

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

scholarly journals Identification of fibers at risk for degeneration by diffusion tractography in patients at high risk for MS after a clinically isolated syndrome

2006 ◽  
Vol 24 (5) ◽  
pp. 983-988 ◽  
Author(s):  
Jack H. Simon ◽  
Song Zhang ◽  
David H. Laidlaw ◽  
David E. Miller ◽  
Mark Brown ◽  
...  
Keyword(s):  
At Risk ◽  
High Risk ◽  
Clinically Isolated Syndrome ◽  
Diffusion Tractography
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