scholarly journals Evaluating and reducing the impact of white matter lesions on brain volume measurements

2011 ◽  
Vol 33 (9) ◽  
pp. 2062-2071 ◽  
Author(s):  
Marco Battaglini ◽  
Mark Jenkinson ◽  
Nicola De Stefano
Keyword(s):  
White Matter ◽  
Brain Volume ◽  
White Matter Lesions ◽  
Volume Measurements ◽  
The Impact

Age dependent white matter lesions and brain volume changes in healthy volunteers

1994 ◽  
Vol 35 (2) ◽  
pp. 117-122 ◽  
Author(s):  
Pernille Christiansen ◽  
H. B. W. Larsson ◽  
C. Thomsen ◽  
S. B. Wieslander ◽  
O. Henriksen
Keyword(s):  
White Matter ◽  
Healthy Volunteers ◽  
Brain Volume ◽  
White Matter Lesions ◽  
Volume Changes ◽  
Age Dependent

scholarly journals Education Modulates the Impact of White Matter Lesions on the Risk of Mild Cognitive Impairment and Dementia

2014 ◽  
Vol 22 (11) ◽  
pp. 1336-1345 ◽  
Author(s):  
Marion Mortamais ◽  
Florence Portet ◽  
Adam M. Brickman ◽  
Frank A. Provenzano ◽  
Jordan Muraskin ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
White Matter Lesions ◽  
The Impact

Age dependent white matter lesions and brain volume changes in healthy volunteers

1994 ◽  
Vol 35 (2) ◽  
pp. 117-122 ◽  
Author(s):  
Pernille Christiansen ◽  
H. B. W. Larsson ◽  
C. Thomsen ◽  
S. B. Wieslander ◽  
O. Henriksen
Keyword(s):  
White Matter ◽  
Healthy Volunteers ◽  
Brain Volume ◽  
White Matter Lesions ◽  
Volume Changes ◽  
Age Dependent

Hippocampal atrophy, whole brain volume, and white matter lesions in older hypertensive subjects

Neurology ◽  
2004 ◽  
Vol 63 (10) ◽  
pp. 1892-1897 ◽  
Author(s):  
R. M. Wiseman ◽  
B. K. Saxby ◽  
E. J. Burton ◽  
R. Barber ◽  
G. A. Ford ◽  
...  
Keyword(s):  
White Matter ◽  
Brain Volume ◽  
White Matter Lesions ◽  
Hippocampal Atrophy ◽  
Whole Brain

scholarly journals Genetic Risk Factors for Longitudinal Changes in Structural MRI in Former Organolead Workers

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Bryan D. James ◽  
Brian Caffo ◽  
Walter F. Stewart ◽  
David Yousem ◽  
Christos Davatzikos ◽  
...  
Keyword(s):  
Risk Factors ◽  
White Matter ◽  
Brain Volume ◽  
Density Lipoprotein ◽  
White Matter Lesions ◽  
Structural Mri ◽  
Population Based ◽  
Effect Modification ◽  
Longitudinal Change ◽  
Brain Volumes

This study examined associations between polymorphisms in three genes, apolipoprotein E (APOE), angiotensin converting enzyme (ACE), and vitamin D receptor (VDR), and longitudinal change in brain volumes and white matter lesions (WML) as well as effect modification by cardiovascular factors and tibia lead concentrations. Two MRIs, an average of 5 years apart, were obtained for 317 former organolead workers and 45 population-based controls. Both regions-of-interest and voxel-wise analyses were conducted.APOEε3/ε4andε4/ε4genotypes were associated with less decline in white matter volumes. There was some evidence of interaction between genetic polymorphisms and cardiovascular risk factors (ACEand high-density lipoprotein;VDRand diabetes) on brain volume decline. TheVDR FokIff genotype was associated with an increase in WML (no association forAPOEorACE). This study expands our understanding of how genetic precursors of dementia and cardiovascular diseases are related to changes in brain structure.

Head size may modify the impact of white matter lesions on dementia

2012 ◽  
Vol 33 (7) ◽  
pp. 1186-1193 ◽  
Author(s):  
Ingmar Skoog ◽  
Pernille J. Olesen ◽  
Kaj Blennow ◽  
Bo Palmertz ◽  
Sterling C. Johnson ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Lesions ◽  
Head Size ◽  
The Impact

scholarly journals Heterogeneity of Cerebral White Matter Lesions and Clinical Correlates in Older Adults

Stroke ◽  
2021 ◽  
Author(s):  
Keun-Hwa Jung ◽  
Kimberly A. Stephens ◽  
Kathryn M. Yochim ◽  
Joost M. Riphagen ◽  
Chan Mi Kim ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Lesions ◽  
Class Ii ◽  
Class I ◽  
Cerebral White Matter ◽  
Imaging Features ◽  
Volume Number ◽  
Human Connectome Project ◽  
Cerebral White Matter Lesions ◽  
The Impact

Background and Purpose: Cerebral white matter signal abnormalities (WMSAs) are a significant radiological marker associated with brain and vascular aging. However, understanding their clinical impact is limited because of their pathobiological heterogeneity. We determined whether use of robust reliable automated procedures can distinguish WMSA classes with different clinical consequences. Methods: Data from generally healthy participants aged >50 years with moderate or greater WMSA were selected from the Human Connectome Project-Aging (n=130). WMSAs were segmented on T1 imaging. Features extracted from WMSA included total and regional volume, number of discontinuous clusters, size of noncontiguous lesion, contrast of lesion intensity relative to surrounding normal appearing tissue using a fully automated procedure. Hierarchical clustering was used to classify individuals into distinct classes of WMSA. Radiological and clinical variability was evaluated across the individual WMSA classes. Results: Class I was characterized by multiple, small, lower-contrast lesions predominantly in the deep WM; class II by large, confluent lesions in the periventricular WM; and class III by higher-contrast lesions restricted to the juxtaventricular WM. Class II was associated with lower myelin content than the other 2 classes. Class II was more prevalent in older subjects and was associated with a higher prevalence of hypertension and lower physical activity levels. Poor sleep quality was associated with a greater risk of class I. Conclusions: We classified heterogeneous subsets of cerebral white matter lesions into distinct classes that have different clinical risk factors. This new method for identifying classes of WMSA will be important in understanding the underlying pathophysiology and in determining the impact on clinical outcomes.

scholarly journals The impact of periventricular white matter lesions in patients with bipolar disorder type I

CNS Spectrums ◽  
2014 ◽  
Vol 21 (1) ◽  
pp. 23-34 ◽  
Author(s):  
Gianluca Serafini ◽  
Maurizio Pompili ◽  
Marco Innamorati ◽  
Nicoletta Girardi ◽  
Leonardo Strusi ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
White Matter ◽  
Rating Scale ◽  
Brain Magnetic Resonance Imaging ◽  
White Matter Lesions ◽  
Periventricular White Matter ◽  
Type I ◽  
Young Mania ◽  
Affective Symptoms ◽  
The Impact

IntroductionWhite matter hyperintensities (WMHs) are one the most common neuroimaging findings in patients with bipolar disorder (BD). It has been suggested that WMHs are associated with impaired insight in schizophrenia and schizoaffective patients; however, the relationship between insight and WMHs in BD type I has not been directly investigated.MethodsPatients with BD-I (148) were recruited and underwent brain magnetic resonance imaging (MRI). Affective symptoms were assessed using Young Mania Rating Scale (YMRS) and Hamilton Depression Rating Scale (HDRS17); the presence of impaired insight was based on the corresponding items of YMRS and HDRS17.ResultsMultiple punctate periventricular WMHs (PWMHs) and deep WMHs (DWMHs) were observed in 49.3% and 39.9% of the cases, respectively. Subjects with lower insight for mania had significantly more PWMHs (54.6% vs 22.2%; p < 0.05) when compared to BD-I patients with higher insight for mania. The presence of PWMHs was independently associated with lower insight for mania: patients who denied illness according to the YMRS were 4 times more likely to have PWMHs (95% CI: 1.21/13.42) than other patients.ConclusionsImpaired insight in BD-I is associated with periventricular WMHs. The early identification of BD-I subjects with PWMHs and impaired insight may be crucial for clinicians.

scholarly journals The Impact of the in utero and Early Postnatal Environments on Grey and White Matter Volume: A Study with Adolescent Monozygotic Twins

2015 ◽  
Vol 37 (6) ◽  
pp. 489-496 ◽  
Author(s):  
Melissa L. Levesque ◽  
Cherine Fahim ◽  
Elmira Ismaylova ◽  
Marie-Pier Verner ◽  
Kevin F. Casey ◽  
...  
Keyword(s):  
White Matter ◽  
Brain Development ◽  
Brain Volume ◽  
Twin Pair ◽  
Statistical Parametric Mapping ◽  
In Utero ◽  
Postnatal Environment ◽  
The Impact ◽  
Parenting Behaviours ◽  
Maternal Hostility

Prenatal and early postnatal adversities have been shown to be associated with brain development. However, we do not know how much of this association is confounded by genetics, nor whether the postnatal environment can moderate the impact of in utero adversity. This study used a monozygotic (MZ) twin design to assess (1) the association between birth weight (BW) and brain volume in adolescence, (2) the association between within-twin-pair BW discordance and brain volume discordance in adolescence, and (3) whether the association between BW and brain volume in adolescence is mediated or moderated by early negative maternal parenting behaviours. These associations were assessed in a sample of 108 MZ twins followed longitudinally since birth and scanned at age 15. The total grey matter (GM) and white matter (WM) volumes were obtained using the Diffeomorphic Anatomical Registration Through Exponentiated Lie Algebra (DARTEL) toolbox in the Statistical Parametric Mapping version 8 (SPM8). We found that the BW was significantly associated with the total GM and WM volumes, particularly in the superior frontal gyrus and thalamus. Within-twin-pair discordance in BW was also significantly associated with within-pair discordance in both the GM and the WM volumes, supporting the hypothesis that the specific in utero environment is associated with brain development independently of genetics. Early maternal hostile parenting behaviours and depressive symptoms were associated with total GM volume but not WM volume. Finally, greater early maternal hostility may moderate the association between the BW and GM volume in adolescence, since the positive association between the BW and total GM volume appeared stronger at higher levels of maternal hostility (trend). Together, these findings support the importance of the in utero and early environments for brain development.

P2-476: RESERVE AS FUNCTIONAL CONNECTIVITY (IN COGNITIVE CONTROL NETWORKS) MODERATES THE IMPACT OF WHITE MATTER LESIONS IN AGING

2006 ◽  
Vol 14 (7S_Part_16) ◽  
pp. P907-P907
Author(s):  
Gloria Benson ◽  
Andrea Hildebrandt ◽  
Catharina Lange ◽  
Theresa Köbe ◽  
Claudia Schwarz ◽  
...  
Keyword(s):  
White Matter ◽  
Functional Connectivity ◽  
Cognitive Control ◽  
White Matter Lesions ◽  
Control Networks ◽  
The Impact
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