scholarly journals Diffusion tensor imaging of the hippocampus and verbal memory performance: The RUN DMC Study

2011 ◽  
Vol 33 (3) ◽  
pp. 542-551 ◽  
Author(s):  
Anouk G.W. van Norden ◽  
Karlijn F. de Laat ◽  
Ilma Fick ◽  
Inge W.M. van Uden ◽  
Lucas J.B. van Oudheusden ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Verbal Memory ◽  
Diffusion Tensor ◽  
Memory Performance

scholarly journals Nicotine Effects on White Matter Microstructure in Young Adults

2019 ◽  
Vol 35 (1) ◽  
pp. 10-21 ◽  
Author(s):  
Megan M Kangiser ◽  
Alicia M Thomas ◽  
Christine M Kaiver ◽  
Krista M Lisdahl
Keyword(s):  
Working Memory ◽  
Young Adults ◽  
White Matter ◽  
Fractional Anisotropy ◽  
Sustained Attention ◽  
Verbal Memory ◽  
Diffusion Tensor ◽  
Memory Performance ◽  
Mean Diffusivity ◽  
White Matter Microstructure

Abstract Objective Nicotine use is widely prevalent among youth, and is associated with white matter microstructural changes as measured by diffusion tensor imaging (DTI). In adults, nicotine use is generally associated with lower fractional anisotropy (FA), but in adolescents/young adults (≤30 years), microstructure appears healthier, indicated by higher FA. This cross-sectional study examined associations between nicotine use and white matter microstructure using fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) in young adults. Methods Fifty-three participants (18 nicotine users [10 female]/35 controls [17 female]) ages 18–25 underwent MRI scan, neuropsychological battery, toxicology screening, and drug use interview. Nicotine group associations with FA and MD were examined in various white matter tracts. In significant tracts, AD and RD were measured. Exploratory correlations were conducted between significant tracts and verbal memory and sustained attention/working memory performance. Results Nicotine users exhibited significantly lower FA than controls in the left anterior thalamic radiation, left inferior longitudinal fasciculus, left superior longitudinal fasciculus—temporal, and left uncinate fasciculus. In these tracts, AD and RD did not differ, nor did MD differ in any tract. White matter quality was positively correlated with sustained attention/working memory performance. Conclusions Cigarette smoking may disrupt white matter microstructure. These results are consistent with adult studies, but inconsistent with adolescent/young adult studies, likely due to methodological and sample age differences. Further studies should examine longitudinal effects of nicotine use on white matter microstructure in a larger sample.

scholarly journals Lifespan trajectories and relationships to memory of the macro- and microstructure of the anterior and posterior hippocampus – a longitudinal multi-modal imaging study

2019 ◽  
Author(s):  
Espen Langnes ◽  
Markus H. Sneve ◽  
Donatas Sederevicius ◽  
Inge K. Amlien ◽  
Kristine B Walhovd ◽  
...  
Keyword(s):  
Episodic Memory ◽  
Verbal Memory ◽  
Structural Changes ◽  
Diffusion Tensor ◽  
Hippocampal Formation ◽  
Memory Performance ◽  
Memory Function ◽  
Imaging Study ◽  
Future Research ◽  
Microstructural Development

AbstractThere is evidence for a hippocampal long axis anterior-posterior (AP) differentiation in memory processing, which may have implications for the changes in episodic memory performance typically seen across development and aging. The hippocampal formation shows substantial structural changes with age, but the lifespan trajectories of hippocampal sub-regions along the AP axis are not established. The aim of the present study was to test whether the micro- and macro-structural age-trajectories of the anterior (aHC) and posterior (pHC) hippocampus are different. In a single-center longitudinal study, 1790 cognitively healthy participants, 4.1-93.4 years of age, underwent a total of 3367 MRI examinations and 3033 memory tests sessions over 1-6 time points, spanning an interval up to 11.1 years. T1-weighted scans were used to estimate the volume of aHC and pHC, and diffusion tensor imaging to measure mean diffusion (MD) within each region. We found that the macro- and microstructural lifespan-trajectories of aHC and pHC were clearly distinguishable, with partly common and partly unique variance shared with age. aHC showed a protracted period of microstructural development, while pHC microstructural development as indexed by MD was more or less completed in early childhood. In contrast, pHC showed larger unique aging-related changes. A similar aHC – pHC difference was observed for volume, although not as evident as for microstructure. All sub-regions showed age-dependent relationships to episodic memory function. For aHC micro- and macrostructure, the relationships to verbal memory performance varied significantly with age, being stronger among the older participants. Future research should disentangle the relationship between these structural properties and different memory processes – encoding vs. retrieval in particular – across the lifespan.

scholarly journals Hippocampal microstructural damage correlates with memory impairment in clinically isolated syndrome suggestive of multiple sclerosis

2016 ◽  
Vol 23 (9) ◽  
pp. 1214-1224 ◽  
Author(s):  
Vincent Planche ◽  
Aurélie Ruet ◽  
Pierrick Coupé ◽  
Delphine Lamargue-Hamel ◽  
Mathilde Deloire ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Verbal Memory ◽  
Predictive Value ◽  
Memory Impairment ◽  
Diffusion Tensor ◽  
Memory Performance ◽  
Mean Diffusivity ◽  
Clinically Isolated Syndrome ◽  
Hippocampal Damage ◽  
Lesion Load

Objective: We investigated whether diffusion tensor imaging (DTI) could reveal early hippocampal damage and clinically relevant correlates of memory impairment in persons with clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS). Methods: A total of 37 persons with CIS, 32 with MS and 36 controls prospectively included from 2011 to 2014 were tested for cognitive performances and scanned with 3T-magnetic resonance imaging (MRI) to assess volumetric and DTI changes within the hippocampus, whole brain volume and T2-lesion load. Results: While there was no hippocampal atrophy in the CIS group, hippocampal fractional anisotropy (FA) was significantly decreased compared to controls. Decrease in hippocampal FA together with increased mean diffusivity (MD) was even more prominent in MS patients. In CIS, hippocampal MD was correlated with episodic verbal memory performance ( r = −0.57, p = 0.0002 and odds ratio (OR) = 0.058, 95% confidence interval (CI) = 0.0057–0.59, p = 0.016 adjusted for age, gender, depression and T2-lesion load), but not with cognitive tasks unrelated to hippocampal functions. Hippocampal MD was the only variable discriminating memory-impaired from memory-preserved persons with CIS (area under the curve (AUC) = 0.77, sensitivity = 90.0%, specificity = 70.3%, positive predictive value (PPV) = 52.9%, negative predictive value (NPV) = 95.0%). Conclusion: DTI alterations within the hippocampus might reflect early neurodegenerative processes that are correlated with episodic memory performance, discriminating persons with CIS according to their memory status.

Structural correlates of memory performance with diffusion tensor imaging

NeuroImage ◽  
2009 ◽  
Vol 47 ◽  
pp. S144
Author(s):  
E Sasson ◽  
GM Doniger ◽  
O Pasternak ◽  
Y Assaf
Keyword(s):  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Memory Performance

scholarly journals White Matter Microstructure Correlates with Memory Performance in Healthy Children: A Diffusion Tensor Imaging Study

2018 ◽  
Vol 29 (2) ◽  
pp. 233-241 ◽  
Author(s):  
Amjad Samara ◽  
Kaiyang Feng ◽  
R. Terry Pivik ◽  
Kelly P. Jarratt ◽  
Thomas M. Badger ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Memory Performance ◽  
Imaging Study ◽  
Healthy Children ◽  
White Matter Microstructure ◽  
With Memory ◽  
Diffusion Tensor Imaging Study

Structural correlates of memory performance with diffusion tensor imaging

NeuroImage ◽  
2010 ◽  
Vol 50 (3) ◽  
pp. 1231-1242 ◽  
Author(s):  
Efrat Sasson ◽  
Glen M. Doniger ◽  
Ofer Pasternak ◽  
Yaniv Assaf
Keyword(s):  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Memory Performance
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