scholarly journals Observer-independent analysis of high-resolution MR images of the human cerebral cortex: In vivo delineation of cortical areas

2006 ◽  
Vol 28 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Nathan B. Walters ◽  
Simon B. Eickhoff ◽  
Axel Schleicher ◽  
Karl Zilles ◽  
Katrin Amunts ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
High Resolution ◽  
Mr Images ◽  
Human Cerebral Cortex ◽  
Cortical Areas ◽  
Independent Analysis

scholarly journals High-resolution in vivo imaging of rhesus cerebral cortex with ultrafast portable photoacoustic microscopy

NeuroImage ◽  
2021 ◽  
pp. 118260
Author(s):  
Wei Qin ◽  
Qi Gan ◽  
Lei Yang ◽  
Yongchao Wang ◽  
Weizhi Qi ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
High Resolution ◽  
In Vivo Imaging ◽  
Photoacoustic Microscopy

scholarly journals Parcellation of the Human Cerebral Cortex Based on Molecular Targets in the Serotonin System Quantified by Positron Emission Tomography In vivo

2018 ◽  
Vol 29 (1) ◽  
pp. 372-382 ◽  
Author(s):  
Gregory M James ◽  
Gregor Gryglewski ◽  
Thomas Vanicek ◽  
Neydher Berroterán-Infante ◽  
Cécile Philippe ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Cerebral Cortex ◽  
Molecular Targets ◽  
Emission Tomography ◽  
Human Cerebral Cortex ◽  
Positron Emission ◽  
Serotonin System

In vivo visualization of single-unit recording sites using MRI-detectable elgiloy deposit marking

2011 ◽  
Vol 105 (3) ◽  
pp. 1380-1392 ◽  
Author(s):  
Kenji W. Koyano ◽  
Akinori Machino ◽  
Masaki Takeda ◽  
Teppei Matsui ◽  
Ryoko Fujimichi ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Single Neuron ◽  
Cognitive Task ◽  
Neuron Activity ◽  
Electrolytic Lesion ◽  
Mr Images ◽  
Gold Standard Method ◽  
Spin Echo Sequence ◽  
Single Neuron Activity

Precise localization of single-neuron activity has elucidated functional architectures of the primate cerebral cortex, related to vertically stacked layers and horizontally aligned columns. The traditional “gold standard” method for localizing recorded neuron is histological examination of electrolytic lesion marks at recording sites. Although this method can localize recorded neurons with fine neuroanatomy, the necessity for postmortem analysis prohibits its use in long-term chronic experiments. To localize recorded single-neuron positions in vivo, we introduced MRI-detectable elgiloy deposit marks, which can be created by electrolysis of an elgiloy microelectrode tip and visualized on highly contrasted magnetic resonance (MR) images. Histological analysis validated that the deposit mark centers could be localized relative to neuroanatomy in vivo with single-voxel accuracy, at an in-plane resolution of 200 μm. To demonstrate practical applications of the technique, we recorded single-neuron activity from a monkey performing a cognitive task and localized it in vivo using deposit marks (deposition: 2 μA for 3 min; scanning: fast-spin-echo sequence with 0.15 × 0.15 × 0.8 mm3 resolution, 120/4,500 ms of echo-time/repetition-time and 8 echo-train-length), as is usually performed with conventional postmortem methods using electrolytic lesion marks. Two localization procedures were demonstrated: 1) deposit marks within a microelectrode track were used to reconstruct a dozen recorded neuron positions along the track directly on MR images; 2) combination with X-ray imaging allowed estimation of hundreds of neuron positions on MR images. This new in vivo method is feasible for chronic experiments with nonhuman primates, enabling analysis of the functional architecture of the cerebral cortex underlying cognitive processes.

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