scholarly journals Localization of MDMA-induced brain activity in healthy volunteers using low resolution brain electromagnetic tomography (LORETA)

2001 ◽  
Vol 14 (3) ◽  
pp. 152-165 ◽  
Author(s):  
Edi Frei ◽  
Alex Gamma ◽  
Roberto Pascual-Marqui ◽  
Dietrich Lehmann ◽  
Daniel Hell ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Brain Activity ◽  
Low Resolution ◽  
Electromagnetic Tomography ◽  
Brain Electromagnetic

scholarly journals Spectrum-specific encephalography standardized low-resolution brain electromagnetic tomography network and gray matter correlations in vascular dementia patients

2020 ◽  
Vol 16 (1) ◽  
pp. 155014771989596
Author(s):  
Yan Lv ◽  
Huijuan Chen ◽  
Zhiyan Sui ◽  
Yingliu Huang ◽  
Shixiong Huang ◽  
...  
Keyword(s):  
Vascular Dementia ◽  
Topological Analysis ◽  
Cognitive Disorder ◽  
Voxel Based Morphometry ◽  
Low Resolution ◽  
Mild Dementia ◽  
Electromagnetic Tomography ◽  
Brain Electromagnetic ◽  
Dementia Patients ◽  
Tomography Analysis

Vascular dementia, secondary to Alzheimer’s dementia, ranks as one of the most frequent dementia types. The process of vascular dementia is divergent with other neurodegenerative dementias and thus reversible at the early cognitive disorder or mild dementia stages. The encephalography and neuroimaging data mining at different stages would bring neuromodulation strategies in practice; 15 mild cognitive impairment patients and 16 mild vascular dementia patients as well as 17 cognitive healthy controls were screened in this study. Cognitive tests such as Mini-Mental State Examination, Montreal cognitive assessment, voxel-based morphometry, electroencephalography, and standardized low-resolution brain electromagnetic tomography connectivity network were conducted. Compared with healthy group, voxel-based morphometry analysis showed a decrease in gray/cerebrospinal fluid ratio ( p < .05) in mild dementia group; the energy power of gamma band decreased ( p < .05) in mild dementia group; and electroencephalography standardized low-resolution brain electromagnetic tomography analysis showed wider frontal and temporal lobe involvement in mild dementia patients ( p < .05). Network topological analysis screened top 10 key Brodmann areas (44R, 7R, 8L, 22L, 47L, 27L, 1L, 1R, 7R, 43L), which could be underlying neuromodulators for dementia patients. Electroencephalography as well as structural magnetic resonance imaging could be used for the evaluation of cognitive disorder patients. The spectrum-specific standardized low-resolution brain electromagnetic tomography analysis and connectivity network analysis could shed light on the neuromodulator targets in the early phase of dementia.

EEG Mapping and Low-Resolution Brain Electromagnetic Tomography (LORETA) in Diagnosis and Therapy of Psychiatric Disorders: Evidence for a Key-Lock Principle

2005 ◽  
Vol 36 (2) ◽  
pp. 108-115 ◽  
Author(s):  
Bernd Saletu ◽  
Peter Anderer ◽  
Gerda M. Saletu-Zyhlarz ◽  
Roberto D. Pascual-Marqui
Keyword(s):  
Psychiatric Disorders ◽  
Brain Function ◽  
Senile Dementia ◽  
Normal Subjects ◽  
Low Resolution ◽  
Specific Patient ◽  
Compulsive Disorder ◽  
Electromagnetic Tomography ◽  
Brain Electromagnetic ◽  
Normal Controls

Different psychiatric disorders, such as schizophrenia with predominantly positive and negative symptomatology, major depression, generalized anxiety disorder, agoraphobia, obsessive-compulsive disorder, multi-infarct dementia, senile dementia of the Alzheimer type and alcohol dependence, show EEG maps that differ statistically both from each other and from normal controls. Representative drugs of the main psychopharmacological classes, such as sedative and non-sedative neuroleptics and antidepressants, tranquilizers, hypnotics, psychostimulants and cognition-enhancing drugs, induce significant and typical changes to normal human brain function, which in many variables are opposite to the above-mentioned differences between psychiatric patients and normal controls. Thus, by considering these differences between psychotropic drugs and placebo in normal subjects, as well as between mental disorder patients and normal controls, it may be possible to choose the optimum drug for a specific patient according to a keylock principle, since the drug should normalize the deviant brain function. This is supported by 3–dimensional low-resolution brain electromagnetic tomography (LORETA), which identifies regions within the brain that are affected by psychiatric disorders and psychopharmacological substances.

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