Treatment resistant depression in the elderly

1995 ◽  
Vol 10 (4) ◽  
pp. 259-264 ◽  
Author(s):  
Deirdre Bonner ◽  
Robert Howard
Keyword(s):  
The Elderly ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Resistant Depression

The Assessment and Management of Treatment Resistant Depression in the Elderly

2018 ◽  
Vol 26 (3) ◽  
pp. S52-S53
Author(s):  
William M. McDonald ◽  
Georgios Petrides ◽  
Scott T. Aaronson ◽  
Patricio Riva Posse
Keyword(s):  
The Elderly ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Resistant Depression

Treatment-resistant Depression in Late Life

CNS Spectrums ◽  
2002 ◽  
Vol 7 (10) ◽  
pp. 733-738 ◽  
Author(s):  
Alastair J. Flint
Keyword(s):  
Major Depression ◽  
Older Patients ◽  
Antidepressant Medication ◽  
Treatment Resistance ◽  
The Elderly ◽  
Stepped Care ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Adequate Dose ◽  
Resistant Depression

ABSTRACTTreatment resistance is reported in up to 40% of older patients with major depression. Before labeling an episode of depression as treatment resistant, it is important to ensure that the diagnosis is correct and that the patient has received and adhered to an adequate dose of treatment for an appropriate length of time. It is also important to assess the patient for comorbid physical and psychiatric conditions that can contribute to treatment resistance. In patients who do not experience remission of symptoms with an adequate trial of medication, the following options can be considered: augmenting the antidepressant with a drug that is not primarily an antidepressant, adding a second antidepressant to the first, switching to a different antidepressant medication, or switching to electroconvulsive therapy. This paper reviews the concept of treatment-resistant depression and discusses its assessment and management in the elderly. The author concludes that when a systematic stepped-care approach to treatment is followed, most older patients with major depression will experience remission of symptoms.

Treatment-Resistant Depression in the Elderly

1995 ◽  
Vol 7 (S1) ◽  
pp. 83-94 ◽  
Author(s):  
Deirdre Bonner ◽  
Robert Howard
Keyword(s):  
Old Age ◽  
The Elderly ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Depressed Patients ◽  
Resistant Depression ◽  
Apparent Resistance

Apparent treatment-resistant depression (TRD) is frequently encountered by and poses particular challenges for the old-age psychiatrist. The prevalence of true nonresponse to treatment is not known with accuracy but reports put it at 18% to 40% for the elderly. This article reviews the concept of TRD in the elderly, discussing the factors involved in apparent resistance and the treatment of this group. We suggest that absolute TRD may be a rarer entity than the estimated 18% to 40% if depressed patients are treated carefully and vigorously.

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