Intraoperative dexmedetomidine for prevention of postoperative delirium in elderly patients with mild cognitive impairment

2020 ◽  
Vol 36 (1) ◽  
pp. 143-151
Author(s):  
Xi Xin ◽  
Jing Chen ◽  
Wei Hua ◽  
Haiyun Wang
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Elderly Patients ◽  
Postoperative Delirium

Role of Inflammatory Markers in Elderly Type 2 Diabetic Patients with Mild Cognitive Impairment

2019 ◽  
Vol 15 (3) ◽  
pp. 247-253 ◽  
Author(s):  
Salwa S. Hosny ◽  
Ahmed M. Bahaaeldin ◽  
Mohamed S. Khater ◽  
Meram M. Bekhet ◽  
Hayam A. Hebah ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Elderly Patients ◽  
Vascular Disease ◽  
Plasma Glucose ◽  
Serum Levels ◽  
Diabetic Patients ◽  
Hs Crp ◽  
And Control

<P>Background: Type 2 diabetes (T2DM) is a risk factor for Alzheimer’s disease and mild cognitive impairment. The etiology of cognitive impairment in people with T2DM is uncertain but, chronic hyperglycemia, cerebral micro vascular disease, severe hypoglycemia, and increased prevalence of macro vascular disease are implicated. </P><P> Objectives: To determine the serum levels of soluble vascular adhesion molecule (sVCAM-1) and highly sensitive C-reactive protein (hs-CRP) in elderly type 2 diabetics with mild cognitive impairment (MCI). Methods: Our study was conducted on 90 elderly subjects (aged 60 years old or more). They were divided into Group І, 30 patients with T2DM and mild cognitive impairment, group ІІ, 30 patients with T2DM without cognitive impairment and group III, 30 healthy subjects as a control group. They were subjected to history taking, full clinical examination, anthropometric measurement, the Addenbrooke’s Cognitive Examination III (ACE---III 2012), Fasting plasma glucose, 2 hours plasma glucose, HbA1c, lipid profile, protein/creatinine ratio, serum sVCAM-1 and hs-CRP. Results: Serum levels of sVCAM-1 in diabetic elderly patients with MCI were significantly higher (946.7 ± 162.01 ng/ml) than diabetic elderly patients without cognitive impairment (479.06 ± 65.27 ng/ml) and control (263.7 ± 72.05 ng/ml) with (P=0.002). Serum levels of Hs-CRP in diabetic elderly patients with MCI were significantly higher than as diabetic elderly patients without cognitive impairment and control with (P=0.005). Conclusion: Elderly diabetic patients with mild cognitive impairment have higher levels of soluble adhesion molecules and markers of low-grade systemic inflammation than other groups.</P>

scholarly journals Postoperative delirium in elderly patients is associated with subsequent cognitive impairment

2017 ◽  
Vol 119 (2) ◽  
pp. 316-323 ◽  
Author(s):  
J. Sprung ◽  
R.O. Roberts ◽  
T.N. Weingarten ◽  
A. Nunes Cavalcante ◽  
D.S. Knopman ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Elderly Patients ◽  
Postoperative Delirium

scholarly journals Intermittent Hypoxia Training for Treating Mild Cognitive Impairment: A Pilot Study

2020 ◽  
Vol 35 ◽  
pp. 153331751989672 ◽  
Author(s):  
Hong Wang ◽  
Xiangrong Shi ◽  
Hannah Schenck ◽  
James R. Hall ◽  
Sarah E. Ross ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Pilot Study ◽  
Elderly Patients ◽  
Intermittent Hypoxia ◽  
Short Term Memory ◽  
Cerebral Oxygenation ◽  
Word Association ◽  
Digit Span ◽  
Verbal Learning

Although intermittent hypoxia training (IHT) has proven effective against various clinical disorders, its impact on mild cognitive impairment (MCI) is unknown. This pilot study examined IHT’s safety and therapeutic efficacy in elderly patients with amnestic MCI (aMCI). Seven patients with aMCI (age 69 ± 3 years) alternately breathed 10% O2 and room-air, each 5 minutes, for 8 cycles/session, 3 sessions/wk for 8 weeks. The patients’ resting arterial pressures fell by 5 to 7 mm Hg ( P < .05) and cerebral tissue oxygenation increased ( P < .05) following IHT. Intermittent hypoxia training enhanced hypoxemia-induced cerebral vasodilation ( P < .05) and improved mini-mental state examination and digit span scores from 25.7 ± 0.4 to 27.7 ± 0.6 ( P = .038) and from 24.7 ± 1.2 to 26.1 ± 1.3 ( P = .047), respectively. California verbal learning test score tended to increase ( P = .102), but trail making test-B and controlled oral word association test scores were unchanged. Adaptation to moderate IHT may enhance cerebral oxygenation and hypoxia-induced cerebrovasodilation while improving short-term memory and attention in elderly patients with aMCI.

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