scholarly journals The anticholinergic effect on cognition ( AEC ) scale—Associations with mortality, hospitalisation and cognitive decline following dementia diagnosis

2020 ◽  
Vol 35 (9) ◽  
pp. 1069-1077 ◽  
Author(s):  
Delia Bishara ◽  
Gayan Perera ◽  
Daniel Harwood ◽  
David Taylor ◽  
Justin Sauer ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Anticholinergic Effect ◽  
Dementia Diagnosis

scholarly journals The anticholinergic effect on cognition (AEC) scale: Associations with mortality, hospitalisation and cognitive decline following dementia diagnosis

2020 ◽  
Vol 16 (S8) ◽  
Author(s):  
Delia Bishara ◽  
Gayan Perera ◽  
Daniel Harwood ◽  
David Taylor ◽  
Justin Sauer ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Anticholinergic Effect ◽  
Dementia Diagnosis

scholarly journals Education, Occupational Class, and Cognitive Decline in Preclinical Dementia

GeroPsych ◽  
2016 ◽  
Vol 29 (1) ◽  
pp. 5-15 ◽  
Author(s):  
Dorina Cadar ◽  
Andrea M. Piccinin ◽  
Scott M. Hofer ◽  
Boo Johansson ◽  
Graciela Muniz-Terrera
Keyword(s):  
Cognitive Decline ◽  
Cognitive Performance ◽  
Random Effects ◽  
Twin Study ◽  
Cognitive Reserve ◽  
Total Sample ◽  
Occupational Class ◽  
Dementia Diagnosis ◽  
Random Effects Models ◽  
Crystallized Abilities

Abstract. We investigated education and occupational influences as markers of cognitive reserve in relation to cognitive performance and decline on multiple fluid and crystallized abilities in preclinical dementia. From the total sample of 702 participants stemming from the OCTO-Twin Study (Sweden), aged 80+ at baseline in 1992–1993, only those who developed dementia during the study period (N = 127) were included in these analyses. Random effects models were used to examine the level of performance at the time of dementia diagnosis and the rates of decline prior to diagnosis. The results demonstrated that both fluid and crystallized abilities decline in preclinical stages, and that education and occupational class have independent moderating roles on the cognitive performance at the time of diagnosis, but not on the rates of decline.

scholarly journals Recurrent delirium over 12 months predicts dementia: results of the Delirium and Cognitive Impact in Dementia (DECIDE) study

2020 ◽  
Author(s):  
Sarah J Richardson ◽  
Daniel H J Davis ◽  
Blossom C M Stephan ◽  
Louise Robinson ◽  
Carol Brayne ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Cognitive Decline ◽  
Hospital Admissions ◽  
Outcome Data ◽  
Illness Severity ◽  
Cognitive Outcomes ◽  
Dementia Diagnosis ◽  
Increased Risk ◽  
The Impact ◽  
Over Time

Abstract Background Delirium is common, distressing and associated with poor outcomes. Previous studies investigating the impact of delirium on cognitive outcomes have been limited by incomplete ascertainment of baseline cognition or lack of prospective delirium assessments. This study quantified the association between delirium and cognitive function over time by prospectively ascertaining delirium in a cohort aged ≥ 65 years in whom baseline cognition had previously been established. Methods For 12 months, we assessed participants from the Cognitive Function and Ageing Study II-Newcastle for delirium daily during hospital admissions. At 1-year, we assessed cognitive decline and dementia in those with and without delirium. We evaluated the effect of delirium (including its duration and number of episodes) on cognitive function over time, independently of baseline cognition and illness severity. Results Eighty two of 205 participants recruited developed delirium in hospital (40%). One-year outcome data were available for 173 participants: 18 had a new dementia diagnosis, 38 had died. Delirium was associated with cognitive decline (−1.8 Mini-Mental State Examination points [95% CI –3.5 to –0.2]) and an increased risk of new dementia diagnosis at follow up (OR 8.8 [95% CI 1.9–41.4]). More than one episode and more days with delirium (>5 days) were associated with worse cognitive outcomes. Conclusions Delirium increases risk of future cognitive decline and dementia, independent of illness severity and baseline cognition, with more episodes associated with worse cognitive outcomes. Given that delirium has been shown to be preventable in some cases, we propose that delirium is a potentially modifiable risk factor for dementia.

scholarly journals Association of cerebral small vessel disease and cognitive decline after intracerebral hemorrhage

Neurology ◽  
2020 ◽  
pp. 10.1212/WNL.0000000000011050
Author(s):  
Marco Pasi ◽  
Lansing Sugita ◽  
Li Xiong ◽  
Andreas Charidimou ◽  
Gregoire Boulouis ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Cognitive Decline ◽  
Cognitive Performance ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Dementia Diagnosis ◽  
Vessel Disease ◽  
Ct Data ◽  
New Onset

Objective:We sought to determine whether MRI-based Cerebral Small Vessel Disease (CSVD) burden assessment, in addition to clinical and CT data, improved prediction of cognitive impairment after spontaneous Intracerebral Hemorrhage (ICH).Methods:We analyzed data from ICH survivors enrolled in a single-center prospective study. We employed three validated CSVD burden scores: global, cerebral amyloid angiopathy (CAA)-specific, hypertensive arteriopathy (HTNA)-specific. We quantified cognitive performance by administering the modified Telephone Interview for Cognitive Status (TICS-m) test. We utilized linear mixed models to model cognitive decline rates, and survival models for new-onset dementia. We calculated CSVD scores’ cut-offs to maximize predictive performance for dementia diagnosis.Results:We enrolled 612 ICH survivors, and followed them for a median of 46.3 months (Inter-Quartile Range: 35.5-58.7). A total of 214/612 (35%) participants developed dementia. Higher global CSVD scores at baseline were associated with faster cognitive decline (Coeff -0.25, Standard Error [SE] 0.02) and dementia risk (Sub-Hazard Ratio 1.35, 95% CI 1.10-1.65). The global score outperformed the CAA and HTNA scores in predicting post-ICH dementia (all p<0.05). Compared to a model including readily available clinical and CT data, inclusion of the global CSVD score resulted in improved prediction of post-ICH dementia (Area Under the Curve [AUC] 0.89, SE 0.02 vs. AUC 0.81, SE 0.03, p = 0.008 for comparison). Global CSVD scores ≥ 2 had highest sensitivity (83%) and specificity (91%) for dementia diagnosis.Conclusions:A validated MRI-based CSVD score is associated with cognitive performance after ICH, and improved diagnostic accuracy for predicting new onset of dementia.

scholarly journals A Coordinated Analysis of the Associations Among Personality Traits, Cognitive Decline, and Dementia

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 9-10
Author(s):  
Eileen Graham ◽  
Kathryn Jackson ◽  
Bryan James ◽  
Emily Willroth ◽  
Daniel Mroczek
Keyword(s):  
Individual Differences ◽  
Cognitive Function ◽  
Cognitive Decline ◽  
Personality Traits ◽  
Regression Models ◽  
Meta Analysis ◽  
Dementia Diagnosis ◽  
Mixed Effect ◽  
Before And After ◽  
Effect Regression

Abstract There are considerable individual differences in the rates of cognitive decline across later adulthood. Personality traits are among the factors that may account for some of these differences. The current project investigated whether personality traits were associated with trajectories of cognitive decline, and whether the associations were different before and after dementia diagnosis. The data were analyzed using linear mixed effect regression models. Across study aims was a focus on replicability and generalizability. Each question was address in four independent longitudinal studies (EAS, MAP, ROS, SATSA), and then meta-analyzed using random effects meta-analysis, providing estimates of heterogeneity. As expected, we detected evidence for cognitive decline in all four samples. Results also indicated that neuroticism and openness were associated with total cognitive function. and openness was associated with decline post dementia diagnosis.

scholarly journals Fast Cognitive Decline at the Time of Dementia Diagnosis: A Major Prognostic Factor for Survival in the Community

2007 ◽  
Vol 23 (6) ◽  
pp. 439-445 ◽  
Author(s):  
Laure Carcaillon ◽  
Karine Pérès ◽  
Jean-Jacques Péré ◽  
Catherine Helmer ◽  
Jean-Marc Orgogozo ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Cognitive Decline ◽  
Dementia Diagnosis ◽  
Major Prognostic Factor
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