Transcranial sonography imaging of brainstem raphe, substantia nigra and cerebral ventricles in patients with geriatric depression

2020 ◽  
Vol 35 (7) ◽  
pp. 702-711
Author(s):  
Başak Şenel ◽  
Erguvan T. Özel‐Kızıl ◽  
Mine H. Sorgun ◽  
Sabiha Tezcan‐Aydemir ◽  
Sevinç Kırıcı
Keyword(s):  
Substantia Nigra ◽  
Transcranial Sonography ◽  
Geriatric Depression ◽  
Cerebral Ventricles ◽  
Brainstem Raphe

scholarly journals Symptom shift in 200 patients with H63D syndrome associated with abnormal TCS findings in substantia nigra

2021 ◽  
Author(s):  
Dr. Carolina Diamandis ◽  
David Seideman ◽  
Jacob S Adams ◽  
Riku Honda ◽  
Marianne Kaufmann ◽  
...  
Keyword(s):  
Statistical Analysis ◽  
Substantia Nigra ◽  
Patient Population ◽  
Inverse Correlation ◽  
Transcranial Sonography ◽  
The Other ◽  
Significant Finding ◽  
Other Hand ◽  
Parallel Increase ◽  
The One

In a study on the prevention of injury in patients with H63D syndrome and cataplexy, statistical analysis revealed an unexpected but clinically highly significant finding. Apparently, in this patient population, an inverse correlation exists between the severity of tic symptomatology on the one hand and narcolepsy with cataplexy on the other hand, as well as a parallel increase in the typical signs of degeneration observed in transcranial sonography of the substantia nigra. This finding has clinically far-reaching implications.

P.6.c.007 Brainstem raphe lesion in MDMA (ecstasy) users recorded on transcranial sonography (TCS)

2011 ◽  
Vol 21 ◽  
pp. S579-S580
Author(s):  
M. Budisic ◽  
M. Strineka ◽  
I. Celic ◽  
D. Karlovic ◽  
D. Buljan ◽  
...  
Keyword(s):  
Transcranial Sonography ◽  
Brainstem Raphe ◽  
Raphe Lesion

Evaluation of basal ganglia, brainstem raphe and ventricles in bipolar disorder by transcranial sonography

2011 ◽  
Vol 194 (2) ◽  
pp. 190-197 ◽  
Author(s):  
Christos Krogias ◽  
Kija Hoffmann ◽  
Jens Eyding ◽  
Dirk Scheele ◽  
Christine Norra ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Basal Ganglia ◽  
Transcranial Sonography ◽  
Brainstem Raphe

Midbrain raphe hypoechogenicity in migraineurs: An indicator for the use of analgesics but not triptans

Cephalalgia ◽  
2016 ◽  
Vol 37 (11) ◽  
pp. 1057-1066 ◽  
Author(s):  
Gordian Hamerla ◽  
Peter Kropp ◽  
Bianca Meyer ◽  
Alessandro Rocco ◽  
Tim P Jürgens ◽  
...  
Keyword(s):  
Transcranial Sonography ◽  
Healthy Individuals ◽  
Self Medication ◽  
Analgesic Drugs ◽  
Validated Questionnaires ◽  
Migraine Frequency ◽  
History Of ◽  
Brainstem Raphe ◽  
Neurophysiologic Evaluation ◽  
Spearman Test

Introduction The involvement of the serotonergic system of the brainstem raphe in the pathogenesis of migraine is discussed. Here we studied brainstem alterations in migraineurs using transcranial sonography and examined their relation to clinical features and self-medication. Methods We investigated 51 migraineurs (11 men, 40 women, mean age 29.7 ± 11.9 years) and 32 healthy individuals without history of headache or depressive disorder (eight men, 24 women, mean age 34.4 ± 13.0 years). Transcranial sonography was performed in an investigator-blinded fashion. Midbrain raphe echogenicity was quantified using digitized analysis. Migraine characteristics and the use of analgesics were evaluated by applying validated questionnaires. Eight migraineurs underwent neurophysiologic evaluation of contingent stimulus-related cortical potentials. Results Echo-reduced midbrain raphe was detected in 27 (53%) migraineurs, but only six (19%) control subjects (odds ratio = 4.87, p = 0.002). Lower raphe echogenicity correlated with both higher amplitude of terminal contingent negative variation (Spearman test, r = 0.76, p = 0.028) and higher use of analgesic drugs ( r = −0.45, p = 0.011), but not with use of triptans or with migraine frequency or severity (all p > 0.2). Compared to migraineurs without aura, migraineurs with aura had enlarged third ventricles (t-test, p = 0.014), while the lateral ventricle widths did not differ ( p = 0.62). Conclusions Midbrain raphe alteration is frequent in migraineurs and relates to self-medication behavior. This alteration may reflect the dysfunction of serotonergic raphe nuclei.

Left-hemispheric predominance of nigrostriatal deficit in isolated REM sleep behavior disorder

Neurology ◽  
2020 ◽  
Vol 94 (15) ◽  
pp. e1605-e1613 ◽  
Author(s):  
Alex Iranzo ◽  
Ambra Stefani ◽  
Aida Niñerola-Baizan ◽  
Heike Stokner ◽  
Monica Serradell ◽  
...  
Keyword(s):  
Substantia Nigra ◽  
Caudate Nucleus ◽  
Rem Sleep ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Transcranial Sonography ◽  
Sleep Behavior ◽  
Left Caudate ◽  
Dat Spect ◽  
The Right

ObjectiveUnilateral onset of parkinsonism due to nigrostriatal damage of the contralateral hemisphere is frequent in Parkinson disease (PD). There is evidence for a left-hemispheric bias of motor asymmetry in right-handed patients with PD indicating a hemispheric dominance. Isolated REM sleep behavior disorder (IRBD) constitutes the prodromal stage of PD and other synucleinopathies. To test the hypothesis that right-handed patients with IRBD exhibit left-hemispheric predominance of subclinical nigrostriatal dysfunction, we evaluated this aspect using neuroimaging instruments.MethodsIn 167 right-handed patients with IRBD without parkinsonism, we evaluated in each hemisphere the integrity of the striatal dopaminergic terminals by dopamine transporter (DAT)-SPECT and the substantia nigra echogenicity by transcranial sonography.ResultsDAT-SPECT showed lower specific binding ratio (SBR) in the left striatum and left caudate nucleus than in the right striatum and right caudate nucleus. The percentage of patients with lower SBR was greater in the left striatum and left caudate nucleus than in the right striatum and right caudate nucleus. In those who developed a synucleinopathy in <5 years from DAT-SPECT, there was a lower SBR in the left putamen and left caudate nucleus than in the right putamen and right caudate nucleus. Substantia nigra echogenic size was greater in the left than in the right side in patients with hyperechogenicity and among individuals who phenoconverted in <5 years from transcranial sonography.ConclusionRight-handed patients with IRBD exhibit left-hemispheric predominance of subclinical nigrostriatal dysfunction. In premotor PD, the neurodegenerative process begins asymmetrically, initially impairing the nigrostriatal system of the dominant hemisphere.

Sign in / Sign up

Export Citation Format

Share Document