Metabolic syndrome and cerebrovascular impairment in Alzheimer's disease

2015 ◽  
Vol 30 (12) ◽  
pp. 1164-1170 ◽  
Author(s):  
Giovanna Viticchi ◽  
Lorenzo Falsetti ◽  
Laura Buratti ◽  
Simona Luzzi ◽  
Marco Bartolini ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Metabolic Syndrome

Is Alzheimer's disease related to metabolic syndrome? A Wnt signaling conundrum

2014 ◽  
Vol 121 ◽  
pp. 125-146 ◽  
Author(s):  
Juvenal A. Ríos ◽  
Pedro Cisternas ◽  
Marco Arrese ◽  
Salesa Barja ◽  
Nibaldo C. Inestrosa
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Metabolic Syndrome ◽  
Wnt Signaling

scholarly journals Changes in Metabolic Syndrome Status and Risk of Dementia

2020 ◽  
Vol 9 (1) ◽  
pp. 122 ◽  
Author(s):  
Ji Eun Lee ◽  
Dong Wook Shin ◽  
Kyungdo Han ◽  
Dahye Kim ◽  
Jung Eun Yoo ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Blood Pressure ◽  
Alzheimer's Disease ◽  
Metabolic Syndrome ◽  
Vascular Dementia ◽  
Proportional Hazards ◽  
Proportional Hazards Model ◽  
Screening Program ◽  
Cox Proportional Hazards ◽  
Cox Proportional Hazards Model

This study investigated the effects of changes in metabolic syndrome (MS) status and each component on subsequent dementia occurrence. The study population was participants of a biennial National Health Screening Program in 2009–2010 and 2011–2012 in Korea. Participants were divided into four groups according to change in MS status during the two-year interval screening: sustained normal, worsened (normal to MS), improved (MS to normal), and sustained MS group. Risk of dementia among the groups was estimated from the second screening date to 31 December 2016 using a Cox proportional hazards model. A total of 4,106,590 participants were included. The mean follow-up was 4.9 years. Compared to the sustained normal group, adjusted hazard ratios (aHR) (95% confidence interval) were 1.11 (1.08–1.13) for total dementia, 1.08 (1.05–1.11) for Alzheimer’s disease, and 1.20 (1.13–1.28) for vascular dementia in the worsened group; 1.12 (1.10–1.15), 1.10 (1.07–1.13), and 1.19 (1.12–1.27) for the improved group; and 1.18 (1.16–1.20), 1.13 (1.11–1.15), and 1.38 (1.32–1.44) for the sustained MS group. Normalization of MS lowered the risk of all dementia types; total dementia (aHR 1.18 versus 1.12), Alzheimer’s disease (1.13 versus 1.10), and vascular dementia (1.38 versus 1.19). Among MS components, fasting glucose and blood pressure showed more impact. In conclusion, changes in MS status were associated with the risk of dementia. Strategies to improve MS, especially hyperglycemia and blood pressure, may help to prevent dementia.

Oxidative Stress, Metabolic Syndrome and Alzheimer’s Disease

2016 ◽  
pp. 361-374 ◽  
Author(s):  
Danira Toral-Rios ◽  
Karla Carvajal ◽  
Bryan Phillips-Farfán ◽  
Luz del Carmen Camacho-Castillo ◽  
Victoria Campos-Peña
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Metabolic Syndrome
Sign in / Sign up

Export Citation Format

Share Document