Retracted: Depression as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies

2012 ◽  
Vol 28 (5) ◽  
pp. 441-449 ◽  
Author(s):  
Yuan Gao ◽  
Changquan Huang ◽  
Kexiang Zhao ◽  
Louyan Ma ◽  
Xuan Qiu ◽  
...  
Keyword(s):  
Risk Factor ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Longitudinal Studies ◽  
Meta Analysis

Long-Term Blood Pressure Variability Increases Risks of Dementia and Cognitive Decline: A Meta-Analysis of Longitudinal Studies

Hypertension ◽  
2021 ◽  
Author(s):  
Pingping Jia ◽  
Helen W.Y. Lee ◽  
Joyce Y.C. Chan ◽  
Karen K.L. Yiu ◽  
Kelvin K.F. Tsoi
Keyword(s):  
Blood Pressure ◽  
Risk Factor ◽  
Cognitive Impairment ◽  
Cognitive Decline ◽  
Longitudinal Studies ◽  
Meta Analysis ◽  
Hazard Ratio ◽  
Literature Searches ◽  
Meta Regression

High blood pressure (BP) is considered as an important risk factor for cognitive impairment and dementia. BP variability (BPV) may contribute to cognitive function decline or even dementia regardless of BP level. This study aims to investigate whether BPV is an independent predictor for cognitive impairment or dementia. Literature searches were performed in MEDLINE, Embase, PsycINFO, CINAHL, and Web of Science to May 2021. Longitudinal studies that assessed the risk of dementia or cognitive impairment with BPV as the predictor was included. Meta-analysis and meta-regression were performed to evaluate the effect of BPV on the risk of dementia or cognitive impairment. A total of 5919 papers were identified, and 16 longitudinal studies were included, which had >7 million participants and a median age from 50.9 to 79.9 years and a median follow-up of around 4 years. Thirteen studies reported visit-to-visit BPV and concluded that systolic BPV increases the risk of dementia with a pooled hazard ratio of 1.11 (95% CI, 1.05–1.17), and increases the risk of cognitive impairment with a pooled hazard ratio of 1.10 (95% CI, 1.06–1.15). Visit-to-visit diastolic BPV also increased the risk of dementia and cognitive decline. A meta-regression revealed a linear relationship between higher BPV and risks of dementia and cognitive impairment. Similar findings were observed in the studies with day-to-day BPV. This study suggests that long-term BPV is an independent risk factor for cognitive impairment or dementia, so an intervention plan for reducing BPV can be a target for early prevention of dementia.

scholarly journals PAŽINTINIŲ GEBĖJIMŲ IR APOLIPOPROTEINO E Ɛ4 GENOTIPO SĄSAJOS: SISTEMINĖ APŽVALGA

Psichologija ◽  
2012 ◽  
Vol 46 ◽  
pp. 123-134
Author(s):  
Laura Sapranavičiūtė ◽  
Abdonas Tamošiūnas
Keyword(s):  
Risk Factor ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Alzheimer Disease ◽  
Apolipoprotein E ◽  
Longitudinal Studies ◽  
Cognitive Functions ◽  
Prognostic Value ◽  
Healthy Adults ◽  
Cognitively Impaired

Senėjimo problemos kontekste pažintinių gebėjimų prastėjimas tampa vis aktualesnė tema. Yra duomenų, kad APOE ɛ4 genotipas prognozuoja prastesnius pažintinius gebėjimus. Taigi, kyla poreikis išsiaiškinti, kurie pažintinių gebėjimų komponentai ir jų pokyčiai siejasi su APOE ɛ4 genotipu. Šio straipsnio tikslas – sisteminės analizės metodu apžvelgti mokslinius tyrimus, analizavusius pažintinių gebėjimų ir APOE ɛ4 genotipo sąsajas.Ankstesnių tyrimų rezultatai atskleidžia, kad turintieji APOE ɛ4 alelį pasižymi prastesniais pažintiniais gebėjimais, palyginti su asmenimis, neturinčiais APOE ɛ4. Dauguma tyrimų įrodo, kad APOE ɛ4 genotipas susijęs su prastesne atmintimi ir vykdomosios funkcijos rezultatais. Kiek rečiau aptinkami APOE ɛ4 ir dėmesio ryšiai. O verbaliniai ir samprotavimo gebėjimai su šio geno polimorfizmu dažniausiai nesiejami. Manoma, kad APOE ɛ4 genotipas gali turėti įtakos pažintinių gebėjimų prastėjimui, tačiau lieka neaiški šio geno polimorfizmo įtaka pažintinių gebėjimų prastėjimui, pasireiškus Alzheimerio ligai.Taigi, APOE ɛ4 genotipas gali būti rizikos veiksnys, susijęs tiek su natūraliu, tiek su patologiniu pažintinių gebėjimų prastėjimu. Tačiau tolesni APOE ɛ4 genotipo ir pažintinių gebėjimų sąsajų tyrimai yra būtimi.Pagrindiniai žodžiai: pažintiniai gebėjimai, APOE ɛ4 genotipas.ASSOCIATIONS BETWEEN COGNITIVE FUNCTIONS AND APOLIPOPROTEIN E Ɛ4 GENOTYPE: SYSTEMIC REVIEWLaura Sapranavičiūtė, Abdonas TamošiūnasSummaryDeterioration of cognitive functions is becoming more and more important issue in context of aging. So there is the growing interest in studies looking for the risk factors of deterioration of cognitive functions. Apolipoprotein E is a plasma protein whose major function is lipids transportation. APOE ɛ4 allele of the Apolipoprotein E gene is known as a risk factor of Alzheimer disease. Previous researchers stated, that APOE ɛ4 also might be related to cognitive performance in normal aging. However results of previous studies are quit confusing: different studies established various associations between APOE ɛ4 and specific cognitive functions. Moreover, longitudinal studies failed to establish prognostic value of APOE ɛ4 genotype to different levels of cognitive functions deterioration. So the purpose of this study is to review prospective, observational, cohort studies that had researched association between APOE ɛ4 and cognitive functions using systematic analysis method.The weight of evidence suggests that APOE ɛ4 is associated with cognitive functions in healthy adults. APOE ɛ4 carriers are likely to have lower level of cognitive functions. Associations between specific cognitive functions and APOE ɛ4 genotype are quit confusing. The most consistent finding was a negative relationship between APOE ɛ4 genotype and performance of memory and executive functioning. Presence of APOE ɛ4 and attention test results was less likely to be associated. Reasoning and verbal abilities were mostly not connected to APOE ɛ4 genotype. Associations between APOE ɛ4 and cognitive function differ in the groups of healthy adults, adults with mild cognitive impairment or Alzheimer disease. There were established that APOE ɛ4 is associated with cognitive functions in cognitively impaired population. People with mild cognitive impairment or Alzheimer disease more often tended to be APOE ɛ4 carriers in comparison with people who are not cognitively impaired. Longitudinal studies revealed different links between APOE ɛ4 and cognitive functions. Although APOE ɛ4 might be a risk factor of deterioration of cognitive functions in healthy and impaired cognitive functions groups. Yet prognostic value of APOE ɛ4 in deterioration of cognitive functions in Alzheimer population is confusing.The current review suggests that APOE ɛ4 has an effect on cognitive functions. It might be a risk factor for deterioration of cognitive functions in healthy adults and cognitively impaired population. However further researches are needed to establish specific associations between APOE ɛ4 genotype and different cognitive functions in healthy adults and disease populations.Keywords: cognitive functions, APOE ɛ4 genotype.

scholarly journals Risk of progression to Alzheimer’s disease for different neuropsychological Mild Cognitive Impairment subtypes: A hierarchical meta-analysis of longitudinal studies.

2018 ◽  
Vol 33 (7) ◽  
pp. 1007-1021 ◽  
Author(s):  
Javier Oltra-Cucarella ◽  
Rosario Ferrer-Cascales ◽  
Montserrat Alegret ◽  
Ruth Gasparini ◽  
Leslie Michelle Díaz-Ortiz ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Longitudinal Studies ◽  
Meta Analysis ◽  
Risk Of Progression

Does loneliness contribute to mild cognitive impairment and dementia? A systematic review and meta-analysis of longitudinal studies

2019 ◽  
Vol 52 ◽  
pp. 7-16 ◽  
Author(s):  
Elvira Lara ◽  
Natalia Martín-María ◽  
Alejandro De la Torre-Luque ◽  
Ai Koyanagi ◽  
Davy Vancampfort ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Longitudinal Studies ◽  
Meta Analysis

Metabolic Syndrome, Mild Cognitive Impairment, and Dementia: A Meta-Analysis of Longitudinal Studies

2019 ◽  
Vol 27 (6) ◽  
pp. 625-637 ◽  
Author(s):  
Anna Rita Atti ◽  
Stefano Valente ◽  
Antonia Iodice ◽  
Ilaria Caramella ◽  
Barbara Ferrari ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Longitudinal Studies ◽  
Meta Analysis
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